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Identifier: 15834942

GI number: 15834942

Start: 380120

End: 381250

Strand: Reverse

Name: Not Available

Synonym: TC0322

Alternate gene names: 15834942

Gene position: 381250-380120 (Counterclockwise)

Preceding gene: 15834943

Following gene: 15834941

Centisome position: 35.53

GC content: 40.41

Gene sequence:

>1131_bases
ATGAATGGTAAGACTCCTTTAGCTCTTTACATACACGTTCCTTTTTGCTCAAAAAAATGTCATTATTGCAGTTTTTACAC
GATCCCATACAAAGAAGAGTTAGTACGCTCTTACTGTGAAGCTGTGATTAAAGAGGGATTAAGAAAGCTAGCTCCTTTGC
GTTGTCATTACTATATCGACACTGTATTTTTTGGAGGAGGGACGCCTTCATTAGTCCCGCCTTCCCTTATTCAGGATATT
CTCACAACGCTGGAAGCTCATTCTGCGACAGAGGTCACCCTTGAAGCCAACCCCGAAAATCTTTCTCAAGAATATATCCG
AGATCTGTCCCAGACCGCGGTTAATCGCATAAGCATTGGTATACAAACCTTTAACGATCCCTTGCTTAAATTACTTGGAC
GAACCCATTCCTCATCTAAAGCGATTGAGACATTCTTACTCTGCTCTCAATACGGCTTTTCTAACTTGTCTGCCGACCTT
ATTTATGGACTCCCCACGCAATCTATTAGCGATTTTATTACCGACCTTCATCAAGCAATTACTCTCCCCATCCAGCATAT
CTCCGTCTATAATCTTACCGTAGATCCTCATACCTCTTTTTACAAACATCGCAAGAGCATTCTTCCTTCCATAGCGGATG
AGGATTCTTTGGCAGAAATGGCACTAAAAGCCGAAGAACTTTTAGAGAATCATGGATTTAATCGATATGAACTAGCCTCT
TATGCAAAAAACCATGCAGAATCTAAACACAATACCTACTACTGGACTGATAAACCTTTTTTAGGATTGGGAGTCTCAGC
TTCGCAATATCTTAACGGCATCCGATCTAAAAATTTTTCTCGGATTTCCCATTATCTAAGAGCCGCGCATCACCATCAAC
CAACTGCAGAATCTATGGAAGAGCTCCCTCCCTGCGAGCGCATTAAAGAAGCTCTAGCCTTACGTCTTCGTCTCTGTGAT
CCCATTCCTTTTTGCATGTTTCCTGAAGAGCTGGTTAATGAAATTTTAATGAACCCATCTATACGTCCTCTATTTGCAAT
AAATGCCCAAACATTTTCATTGAATAAACAAGGCCGACTTTTTCATGATTCTATAGCAGAAGAAATCATGTGTTCTTCTT
TTTCATTTTAA

Upstream 100 bases:

>100_bases
GAGAGCGGAAGTGAACTCGATTATTCCAGCGAAGACGATGAAGATCCTTTCAGTGATCGCAATCGTTGGCGCCGAGGAGG
CATCATAGATCCAGACGCAA

Downstream 100 bases:

>100_bases
AAATAAAAAATTAATCGATATTAAAACCAATAAAACTAATCGATTAATTTTTAATTGAAAAATGAATAAAAACAAAAAAA
ACAACCAATTTTAATGCATC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MNGKTPLALYIHVPFCSKKCHYCSFYTIPYKEELVRSYCEAVIKEGLRKLAPLRCHYYIDTVFFGGGTPSLVPPSLIQDI
LTTLEAHSATEVTLEANPENLSQEYIRDLSQTAVNRISIGIQTFNDPLLKLLGRTHSSSKAIETFLLCSQYGFSNLSADL
IYGLPTQSISDFITDLHQAITLPIQHISVYNLTVDPHTSFYKHRKSILPSIADEDSLAEMALKAEELLENHGFNRYELAS
YAKNHAESKHNTYYWTDKPFLGLGVSASQYLNGIRSKNFSRISHYLRAAHHHQPTAESMEELPPCERIKEALALRLRLCD
PIPFCMFPEELVNEILMNPSIRPLFAINAQTFSLNKQGRLFHDSIAEEIMCSSFSF

Sequences:

>Translated_376_residues
MNGKTPLALYIHVPFCSKKCHYCSFYTIPYKEELVRSYCEAVIKEGLRKLAPLRCHYYIDTVFFGGGTPSLVPPSLIQDI
LTTLEAHSATEVTLEANPENLSQEYIRDLSQTAVNRISIGIQTFNDPLLKLLGRTHSSSKAIETFLLCSQYGFSNLSADL
IYGLPTQSISDFITDLHQAITLPIQHISVYNLTVDPHTSFYKHRKSILPSIADEDSLAEMALKAEELLENHGFNRYELAS
YAKNHAESKHNTYYWTDKPFLGLGVSASQYLNGIRSKNFSRISHYLRAAHHHQPTAESMEELPPCERIKEALALRLRLCD
PIPFCMFPEELVNEILMNPSIRPLFAINAQTFSLNKQGRLFHDSIAEEIMCSSFSF
>Mature_376_residues
MNGKTPLALYIHVPFCSKKCHYCSFYTIPYKEELVRSYCEAVIKEGLRKLAPLRCHYYIDTVFFGGGTPSLVPPSLIQDI
LTTLEAHSATEVTLEANPENLSQEYIRDLSQTAVNRISIGIQTFNDPLLKLLGRTHSSSKAIETFLLCSQYGFSNLSADL
IYGLPTQSISDFITDLHQAITLPIQHISVYNLTVDPHTSFYKHRKSILPSIADEDSLAEMALKAEELLENHGFNRYELAS
YAKNHAESKHNTYYWTDKPFLGLGVSASQYLNGIRSKNFSRISHYLRAAHHHQPTAESMEELPPCERIKEALALRLRLCD
PIPFCMFPEELVNEILMNPSIRPLFAINAQTFSLNKQGRLFHDSIAEEIMCSSFSF

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=267, Percent_Identity=35.2059925093633, Blast_Score=168, Evalue=8e-42,
Organism=Escherichia coli, GI1789325, Length=380, Percent_Identity=31.3157894736842, Blast_Score=177, Evalue=7e-46,
Organism=Escherichia coli, GI87082341, Length=297, Percent_Identity=26.5993265993266, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42618; Mature: 42618

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGKTPLALYIHVPFCSKKCHYCSFYTIPYKEELVRSYCEAVIKEGLRKLAPLRCHYYID
CCCCCCEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
TVFFGGGTPSLVPPSLIQDILTTLEAHSATEVTLEANPENLSQEYIRDLSQTAVNRISIG
EEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
IQTFNDPLLKLLGRTHSSSKAIETFLLCSQYGFSNLSADLIYGLPTQSISDFITDLHQAI
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHEECCCHHHHHHHHHHHHHHH
TLPIQHISVYNLTVDPHTSFYKHRKSILPSIADEDSLAEMALKAEELLENHGFNRYELAS
HHHHHHEEEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
YAKNHAESKHNTYYWTDKPFLGLGVSASQYLNGIRSKNFSRISHYLRAAHHHQPTAESME
HHHHHCCCCCCCEEECCCCCEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHH
ELPPCERIKEALALRLRLCDPIPFCMFPEELVNEILMNPSIRPLFAINAQTFSLNKQGRL
HCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCEEEECCCCCCH
FHDSIAEEIMCSSFSF
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNGKTPLALYIHVPFCSKKCHYCSFYTIPYKEELVRSYCEAVIKEGLRKLAPLRCHYYID
CCCCCCEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
TVFFGGGTPSLVPPSLIQDILTTLEAHSATEVTLEANPENLSQEYIRDLSQTAVNRISIG
EEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
IQTFNDPLLKLLGRTHSSSKAIETFLLCSQYGFSNLSADLIYGLPTQSISDFITDLHQAI
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHEECCCHHHHHHHHHHHHHHH
TLPIQHISVYNLTVDPHTSFYKHRKSILPSIADEDSLAEMALKAEELLENHGFNRYELAS
HHHHHHEEEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
YAKNHAESKHNTYYWTDKPFLGLGVSASQYLNGIRSKNFSRISHYLRAAHHHQPTAESME
HHHHHCCCCCCCEEECCCCCEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHH
ELPPCERIKEALALRLRLCDPIPFCMFPEELVNEILMNPSIRPLFAINAQTFSLNKQGRL
HCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCEEEECCCCCCH
FHDSIAEEIMCSSFSF
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]