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The map label for this gene is pepA

Identifier: 15834935

GI number: 15834935

Start: 371717

End: 373216

Strand: Direct

Name: pepA

Synonym: TC0315

Alternate gene names: 15834935

Gene position: 371717-373216 (Clockwise)

Preceding gene: 15834934

Following gene: 15834936

Centisome position: 34.64

GC content: 41.2

Gene sequence:

>1500_bases
GTGGTGTTGCTCTATTCTCAAGCGAGTTGGGATAAACGATCGAAAGCAGATGCGCTTGTTCTTCCTTTTTGGATGAAGAA
CGTTAAAGCTCAAGAGGCTGCAGTTGTTGATGAGGACTACAAGCTTGTCTATCAAAACGCATTACAAAATTTTTCTGGAA
AGAAGGGGGAAGCTGTTTTTCTTTTTGGAAATGATAAAACCAAAGAGCAAAAAATAGTTCTTCTAGGGTTAGGAAAGAGC
GAGGAGGTTTCCGGGACTGCAATTTTGGATGCCTATGCTCATGTTACTACAGTTTTACGAAAAGCTAAGTGTAAGACTGT
AAATATTTTGTTACCTACTATTTCGCAGTTGCGTTTCTCTGTAGAAGAATTTTTGACGAATCTAGCTGCAGGAGTTCTTT
CTCTTAACTATAACTATCCGACTTATCATAAAGTCGATGCCTCCTTGCCTTTATTAGAAAAAGTCACTGTATTGGGGATT
GTTCCTAAAGTAGGAGACAAGATTTTTAGAAAAGAAGAGAGCTTATTTGAAGGAGTATATTTAACACGAGATTTAGTAAA
TACGAATGCTGATGAGGTAACTCCAGAAAAACTTGCTGCTGTTGCTAAGGGACTAGCTGGAGAATTTGCTAGTTTGGACG
TCAAGATCCTTGATAGGAAAGCCATATTAAAAGAGAAGATGGGACTATTGGCCGCAGTCGCTAAGGGGTCGGCTGTTGAA
CCTCGGTTTATTGTTCTGGATTATCAAGGAAAACCTAAGTCAAAAGATAGAACGGTGCTCATTGGTAAGGGGGTGACGTT
TGACTCCGGTGGATTAGATTTGAAGCCTGGTAAGGCGATGATCACTATGAAAGAAGATATGGCTGGAGCAGCTACAGTTT
TGGGCATTTTTTCTGCATTGGCTTCTTTAGAACTCCCTATCAATGTGACAGGAATCATTCCTGCTACGGAGAACGCTATA
GGATCTGCAGCTTATAAGATGGGAGATGTCTATGTGGGCATGTCTGGGCTGTCTGTAGAAATTGGAAGCACAGATGCTGA
GGGAAGACTTATTTTAGCGGATGCGATTACCTATGCTTTGAAGTATTGCGCCCCTACGCGAATTATTGATTTTGCCACTT
TGACAGGAGCCATGGTGGTTTCTTTAGGAGAAGCTGTAGCTGGATTTTTTGCTAACAATGACGTTTTGGCTAGGGATTTG
GCAGAGGCTGCATCAGAGACTGGGGAGGCCCTTTGGAGAATGCCTTTAGTCGAAAAATATGACCGTGCTCTTCATTCAGA
TATTGCAGACATGAAAAATATCGGAAGCAACCGAGCAGGGTCCATTACTGCGGCTCTGTTTCTACAACGTTTTCTTGAAG
ACAATCCAGTAGCGTGGGCACATTTGGATATTGCTGGTACCGCTTACCATGAAAAAGAAGAGCTTCCTTATCCTAAATAT
GCAACAGGATTTGGTGTTCGTTGTTTAATTTATTATATGAACAAGTTTTTATCTAAATAG

Upstream 100 bases:

>100_bases
CGGAGTCAATTGTTTGGCCAGGTCGCCAGTTTGAGATGGGAATTTGCAAAACGCGTTCTGCTTGTAATTTTGACTCAATC
GATTCAACAAAGAGGTTATT

Downstream 100 bases:

>100_bases
TTCTTGTTTAGGTTTGTCAAAATAAAAAGATTTGGTTGGTTTTTAATTTTTTTATTAAAAACCAACCTTTTTTATTAAAG
TTTTTCATTCTTCCTGTCGA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MVLLYSQASWDKRSKADALVLPFWMKNVKAQEAAVVDEDYKLVYQNALQNFSGKKGEAVFLFGNDKTKEQKIVLLGLGKS
EEVSGTAILDAYAHVTTVLRKAKCKTVNILLPTISQLRFSVEEFLTNLAAGVLSLNYNYPTYHKVDASLPLLEKVTVLGI
VPKVGDKIFRKEESLFEGVYLTRDLVNTNADEVTPEKLAAVAKGLAGEFASLDVKILDRKAILKEKMGLLAAVAKGSAVE
PRFIVLDYQGKPKSKDRTVLIGKGVTFDSGGLDLKPGKAMITMKEDMAGAATVLGIFSALASLELPINVTGIIPATENAI
GSAAYKMGDVYVGMSGLSVEIGSTDAEGRLILADAITYALKYCAPTRIIDFATLTGAMVVSLGEAVAGFFANNDVLARDL
AEAASETGEALWRMPLVEKYDRALHSDIADMKNIGSNRAGSITAALFLQRFLEDNPVAWAHLDIAGTAYHEKEELPYPKY
ATGFGVRCLIYYMNKFLSK

Sequences:

>Translated_499_residues
MVLLYSQASWDKRSKADALVLPFWMKNVKAQEAAVVDEDYKLVYQNALQNFSGKKGEAVFLFGNDKTKEQKIVLLGLGKS
EEVSGTAILDAYAHVTTVLRKAKCKTVNILLPTISQLRFSVEEFLTNLAAGVLSLNYNYPTYHKVDASLPLLEKVTVLGI
VPKVGDKIFRKEESLFEGVYLTRDLVNTNADEVTPEKLAAVAKGLAGEFASLDVKILDRKAILKEKMGLLAAVAKGSAVE
PRFIVLDYQGKPKSKDRTVLIGKGVTFDSGGLDLKPGKAMITMKEDMAGAATVLGIFSALASLELPINVTGIIPATENAI
GSAAYKMGDVYVGMSGLSVEIGSTDAEGRLILADAITYALKYCAPTRIIDFATLTGAMVVSLGEAVAGFFANNDVLARDL
AEAASETGEALWRMPLVEKYDRALHSDIADMKNIGSNRAGSITAALFLQRFLEDNPVAWAHLDIAGTAYHEKEELPYPKY
ATGFGVRCLIYYMNKFLSK
>Mature_499_residues
MVLLYSQASWDKRSKADALVLPFWMKNVKAQEAAVVDEDYKLVYQNALQNFSGKKGEAVFLFGNDKTKEQKIVLLGLGKS
EEVSGTAILDAYAHVTTVLRKAKCKTVNILLPTISQLRFSVEEFLTNLAAGVLSLNYNYPTYHKVDASLPLLEKVTVLGI
VPKVGDKIFRKEESLFEGVYLTRDLVNTNADEVTPEKLAAVAKGLAGEFASLDVKILDRKAILKEKMGLLAAVAKGSAVE
PRFIVLDYQGKPKSKDRTVLIGKGVTFDSGGLDLKPGKAMITMKEDMAGAATVLGIFSALASLELPINVTGIIPATENAI
GSAAYKMGDVYVGMSGLSVEIGSTDAEGRLILADAITYALKYCAPTRIIDFATLTGAMVVSLGEAVAGFFANNDVLARDL
AEAASETGEALWRMPLVEKYDRALHSDIADMKNIGSNRAGSITAALFLQRFLEDNPVAWAHLDIAGTAYHEKEELPYPKY
ATGFGVRCLIYYMNKFLSK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=338, Percent_Identity=42.603550295858, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI47155554, Length=329, Percent_Identity=33.434650455927, Blast_Score=137, Evalue=3e-32,
Organism=Escherichia coli, GI1790710, Length=466, Percent_Identity=33.2618025751073, Blast_Score=234, Evalue=8e-63,
Organism=Escherichia coli, GI87082123, Length=337, Percent_Identity=35.9050445103858, Blast_Score=173, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17556903, Length=308, Percent_Identity=33.4415584415584, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=360, Percent_Identity=30.2777777777778, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24661038, Length=324, Percent_Identity=34.5679012345679, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21355725, Length=323, Percent_Identity=34.3653250773994, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI20129969, Length=322, Percent_Identity=32.2981366459627, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24662227, Length=322, Percent_Identity=31.055900621118, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21357381, Length=321, Percent_Identity=33.6448598130841, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI221379063, Length=321, Percent_Identity=33.6448598130841, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI221379062, Length=321, Percent_Identity=33.6448598130841, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI161077148, Length=323, Percent_Identity=31.5789473684211, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI20130057, Length=323, Percent_Identity=31.5789473684211, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI19922386, Length=330, Percent_Identity=31.2121212121212, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI20129963, Length=323, Percent_Identity=30.9597523219814, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21355645, Length=323, Percent_Identity=29.7213622291022, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24662223, Length=323, Percent_Identity=29.7213622291022, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646701, Length=348, Percent_Identity=28.735632183908, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24646703, Length=348, Percent_Identity=28.735632183908, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21358201, Length=348, Percent_Identity=28.735632183908, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_CHLMU (P38019)

Other databases:

- EMBL:   AE002160
- EMBL:   M86605
- PIR:   F81715
- RefSeq:   NP_296694.1
- ProteinModelPortal:   P38019
- GeneID:   1246358
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0315
- TIGR:   TC_0315
- HOGENOM:   HBG742580
- OMA:   CKPTRII
- PhylomeDB:   P38019
- ProtClustDB:   PRK00913
- BioCyc:   CMUR243161:TC_0315-MONOMER
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 54109; Mature: 54109

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 275-275 ACT_SITE 349-349

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLLYSQASWDKRSKADALVLPFWMKNVKAQEAAVVDEDYKLVYQNALQNFSGKKGEAVF
CEEEEECCCCCCCCCCCEEEEEHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEE
LFGNDKTKEQKIVLLGLGKSEEVSGTAILDAYAHVTTVLRKAKCKTVNILLPTISQLRFS
EECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHH
VEEFLTNLAAGVLSLNYNYPTYHKVDASLPLLEKVTVLGIVPKVGDKIFRKEESLFEGVY
HHHHHHHHHHHHEEECCCCCCCEECCCCCCHHHHHHHHEECHHHHHHHHHHHHHHHHHHH
LTRDLVNTNADEVTPEKLAAVAKGLAGEFASLDVKILDRKAILKEKMGLLAAVAKGSAVE
HHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHCEEEEHHHHHHHHHHHHHHHHHHCCCCCC
PRFIVLDYQGKPKSKDRTVLIGKGVTFDSGGLDLKPGKAMITMKEDMAGAATVLGIFSAL
CEEEEEEECCCCCCCCCEEEEECCEEECCCCCEECCCCEEEEEHHHCCHHHHHHHHHHHH
ASLELPINVTGIIPATENAIGSAAYKMGDVYVGMSGLSVEIGSTDAEGRLILADAITYAL
HHCCCCEEEEEEECCCCCHHHHHHHHHCCEEEECCCCEEEECCCCCCCCEEEHHHHHHHH
KYCAPTRIIDFATLTGAMVVSLGEAVAGFFANNDVLARDLAEAASETGEALWRMPLVEKY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHH
DRALHSDIADMKNIGSNRAGSITAALFLQRFLEDNPVAWAHLDIAGTAYHEKEELPYPKY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCC
ATGFGVRCLIYYMNKFLSK
CCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLLYSQASWDKRSKADALVLPFWMKNVKAQEAAVVDEDYKLVYQNALQNFSGKKGEAVF
CEEEEECCCCCCCCCCCEEEEEHHHHCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEE
LFGNDKTKEQKIVLLGLGKSEEVSGTAILDAYAHVTTVLRKAKCKTVNILLPTISQLRFS
EECCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHH
VEEFLTNLAAGVLSLNYNYPTYHKVDASLPLLEKVTVLGIVPKVGDKIFRKEESLFEGVY
HHHHHHHHHHHHEEECCCCCCCEECCCCCCHHHHHHHHEECHHHHHHHHHHHHHHHHHHH
LTRDLVNTNADEVTPEKLAAVAKGLAGEFASLDVKILDRKAILKEKMGLLAAVAKGSAVE
HHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHCEEEEHHHHHHHHHHHHHHHHHHCCCCCC
PRFIVLDYQGKPKSKDRTVLIGKGVTFDSGGLDLKPGKAMITMKEDMAGAATVLGIFSAL
CEEEEEEECCCCCCCCCEEEEECCEEECCCCCEECCCCEEEEEHHHCCHHHHHHHHHHHH
ASLELPINVTGIIPATENAIGSAAYKMGDVYVGMSGLSVEIGSTDAEGRLILADAITYAL
HHCCCCEEEEEEECCCCCHHHHHHHHHCCEEEECCCCEEEECCCCCCCCEEEHHHHHHHH
KYCAPTRIIDFATLTGAMVVSLGEAVAGFFANNDVLARDLAEAASETGEALWRMPLVEKY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHH
DRALHSDIADMKNIGSNRAGSITAALFLQRFLEDNPVAWAHLDIAGTAYHEKEELPYPKY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCC
ATGFGVRCLIYYMNKFLSK
CCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935; 1549572