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The map label for this gene is gmk

Identifier: 15834919

GI number: 15834919

Start: 355946

End: 356563

Strand: Direct

Name: gmk

Synonym: TC0299

Alternate gene names: 15834919

Gene position: 355946-356563 (Clockwise)

Preceding gene: 15834918

Following gene: 15834920

Centisome position: 33.17

GC content: 40.29

Gene sequence:

>618_bases
ATGTCAGTAAAGGTTGCTTCCCCTTTTTCTCCAGATGGGGTCCAATGCCTTCCTAAACTTTTTACTATCAGTGCTCCTGC
TGGAGCGGGGAAGACAACTTTAGTTCATATGTTACAAGAAGAATTCCCTTCTGCTTTTGAAAAAACTGTTTCTTCAACAA
CGCGTTCGCCTCGTCCCGGAGAAGTTCATGGCGTTGATTATGTGTTTATGTCTGAGGACGAATTTAAGGATGTTCTAGAT
AAGGACGGTTTTTTAGAATGGGTCTTTTTATTTGGGACCTATTATGGGACTAGTAAGGAAGGGATTTCTAGAATTCTCCA
AAAGGGGAAACATTGCATTGCGGTGATTGATGTGCAAGGCGCTTTGACTTTGAAAAAGCAAATGCAAACAGTGGCTATTT
TTATTCAGGCTCCTTCTCAAGAAGAACTCGAGAGACGTCTAAATACTCGGGATTCAGAAAAGGATCTCCAAAAAAAAGAG
AGATTGGAGCATAGCAATGTGGAAATTGCTGCTGCCAGTCAATTCGATTACGTTGTTGTTAACGATGATTTAACCACTGC
GTATCAAGTTTTAAGAAGTATTTTTATAGCTGAAGAACATAGGATGAGTCATGGCTAG

Upstream 100 bases:

>100_bases
ATGGAACGGTTGCGCATTTGCAAGCTTTAAAACAGTTTGGCCCTTGCGTATATCACAGAAAGAGTTTCTCTCCTGTAAAA
GAGAGTATCCGAGAGGGAAT

Downstream 100 bases:

>100_bases
AAAAGAGCGTTTAACTAATGAAAAACTAAATAAGCTATTCGATAGCCCTTTTAGTTTGGTTAATTATGTGATTAAACAAA
CTAAAAACAGAATTGCTAGG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MSVKVASPFSPDGVQCLPKLFTISAPAGAGKTTLVHMLQEEFPSAFEKTVSSTTRSPRPGEVHGVDYVFMSEDEFKDVLD
KDGFLEWVFLFGTYYGTSKEGISRILQKGKHCIAVIDVQGALTLKKQMQTVAIFIQAPSQEELERRLNTRDSEKDLQKKE
RLEHSNVEIAAASQFDYVVVNDDLTTAYQVLRSIFIAEEHRMSHG

Sequences:

>Translated_205_residues
MSVKVASPFSPDGVQCLPKLFTISAPAGAGKTTLVHMLQEEFPSAFEKTVSSTTRSPRPGEVHGVDYVFMSEDEFKDVLD
KDGFLEWVFLFGTYYGTSKEGISRILQKGKHCIAVIDVQGALTLKKQMQTVAIFIQAPSQEELERRLNTRDSEKDLQKKE
RLEHSNVEIAAASQFDYVVVNDDLTTAYQVLRSIFIAEEHRMSHG
>Mature_204_residues
SVKVASPFSPDGVQCLPKLFTISAPAGAGKTTLVHMLQEEFPSAFEKTVSSTTRSPRPGEVHGVDYVFMSEDEFKDVLDK
DGFLEWVFLFGTYYGTSKEGISRILQKGKHCIAVIDVQGALTLKKQMQTVAIFIQAPSQEELERRLNTRDSEKDLQKKER
LEHSNVEIAAASQFDYVVVNDDLTTAYQVLRSIFIAEEHRMSHG

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=185, Percent_Identity=32.972972972973, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI226874833, Length=185, Percent_Identity=32.972972972973, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4504221, Length=185, Percent_Identity=32.972972972973, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI14780902, Length=196, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI38570142, Length=175, Percent_Identity=31.4285714285714, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI111154074, Length=167, Percent_Identity=33.5329341317365, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI148539628, Length=175, Percent_Identity=30.2857142857143, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI148539578, Length=175, Percent_Identity=30.2857142857143, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI21361598, Length=185, Percent_Identity=27.5675675675676, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI119943106, Length=165, Percent_Identity=31.5151515151515, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI119943108, Length=165, Percent_Identity=31.5151515151515, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI261862237, Length=175, Percent_Identity=30.8571428571429, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=188, Percent_Identity=44.1489361702128, Blast_Score=151, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI193203132, Length=179, Percent_Identity=37.9888268156425, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17508835, Length=179, Percent_Identity=37.9888268156425, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71984092, Length=120, Percent_Identity=31.6666666666667, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557440, Length=176, Percent_Identity=26.7045454545455, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=187, Percent_Identity=40.1069518716578, Blast_Score=144, Evalue=7e-36,
Organism=Drosophila melanogaster, GI21356141, Length=185, Percent_Identity=36.2162162162162, Blast_Score=121, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_CHLMU (Q9PL09)

Other databases:

- EMBL:   AE002160
- PIR:   F81718
- RefSeq:   NP_296678.1
- ProteinModelPortal:   Q9PL09
- SMR:   Q9PL09
- GeneID:   1246469
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0299
- TIGR:   TC_0299
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- PhylomeDB:   Q9PL09
- ProtClustDB:   PRK00300
- BioCyc:   CMUR243161:TC_0299-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 22977; Mature: 22846

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKVASPFSPDGVQCLPKLFTISAPAGAGKTTLVHMLQEEFPSAFEKTVSSTTRSPRPG
CCEEECCCCCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EVHGVDYVFMSEDEFKDVLDKDGFLEWVFLFGTYYGTSKEGISRILQKGKHCIAVIDVQG
CCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCC
ALTLKKQMQTVAIFIQAPSQEELERRLNTRDSEKDLQKKERLEHSNVEIAAASQFDYVVV
HHHHHHHHHEEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEEECCCCEEEE
NDDLTTAYQVLRSIFIAEEHRMSHG
CCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVKVASPFSPDGVQCLPKLFTISAPAGAGKTTLVHMLQEEFPSAFEKTVSSTTRSPRPG
CEEECCCCCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EVHGVDYVFMSEDEFKDVLDKDGFLEWVFLFGTYYGTSKEGISRILQKGKHCIAVIDVQG
CCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCC
ALTLKKQMQTVAIFIQAPSQEELERRLNTRDSEKDLQKKERLEHSNVEIAAASQFDYVVV
HHHHHHHHHEEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEEECCCCEEEE
NDDLTTAYQVLRSIFIAEEHRMSHG
CCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935