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Identifier: 15834913

GI number: 15834913

Start: 351221

End: 352093

Strand: Direct

Name: Not Available

Synonym: TC0293

Alternate gene names: 15834913

Gene position: 351221-352093 (Clockwise)

Preceding gene: 15834912

Following gene: 15834914

Centisome position: 32.73

GC content: 40.21

Gene sequence:

>873_bases
ATGAAGAGACTAATTAAGGAAGCTTCAGAATATCTGTTATCTCGAGGGATTCGGTTTCCTCAAAGGGAAGCCGAAGATAT
CATGATGGATTTACTAGAGGTTTCTTCTAGAGGGGCTCTTCATGATATAAAATTATCGAGCGGAGAGCGGGTTTCATACT
GGGAACGTGTGCAGAAAAGGGGAAATCGTTGTCCTACTGCTTATATTCATGGCAAGGTGCATTTTTTAGGAATTGAGTTG
CAGGTATCCCCTGAGGTTCTTATTCCTAGGCAAGAAACTGAAATTTTTGTTGAAAAGATTATTGGTTATTTGCAGACGCA
TAAAGAAAAAAAGATTTTTTATGATGTTTGCTGTGGGAGTGGGTGTATTGGGTTGTCTGTAAAGAAACACTGTCCCCATG
TACACGTTGTGCTGTCAGATATTTGTTCACAGGCTTTGGCTGTTGCTAAGTCAAATGCAAAAAGAAACGATCTTATTGTA
GATTTTCTTTGTGGGGATTTATTCGAGCCTTTCCGTATTCCAGCAGATGCTTTCGTCTGCAATCCTCCTTATCTGTCATA
TAAAGAGTTTTTTAAAGTGGATCCTGAAGTGCGCTGTCATGAACCTTGGAAGGCTTTAGTTGGGGGCGTTTCTGGGTTGG
AATTTTATCATCGTATAGCCGAACATATTCACAAAATTTTGGTTCCCGGGGGAGTTGGTTGGTTAGAAATTGGCTCAAAT
CAAGGGGAGAGTGTCAAAAAAATTTTTCGTGATAAGGGAATTTCTGGATGTGTATTCAAAGATTACGCTCAGTTAGATAG
GTTTTTTTTCCTTGAAAATCAAGCTGGTGATGCTGTATCCTCTGGGGAGGTTTCTGGCTTTTCCGAGAGATGA

Upstream 100 bases:

>100_bases
ATCGGTCTGACTTTATATAACTTGGATCGTGTAATGCAGGGAGAGTTGGATATGATTACAACAGCTCTTGTTTCCCATGC
ACATCGCCAACTGTTCGGTC

Downstream 100 bases:

>100_bases
TTAATTCTTTATCGCAAAAATTATCTAGTATTTTCTCCTCACTTTTTACTGCAAAGAGAGTAACAGAGGAGAGTATTTCT
GATTCCATTAGAGAAATTCG

Product: N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase

Products: NA

Alternate protein names: M.AaoHemKP [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKRLIKEASEYLLSRGIRFPQREAEDIMMDLLEVSSRGALHDIKLSSGERVSYWERVQKRGNRCPTAYIHGKVHFLGIEL
QVSPEVLIPRQETEIFVEKIIGYLQTHKEKKIFYDVCCGSGCIGLSVKKHCPHVHVVLSDICSQALAVAKSNAKRNDLIV
DFLCGDLFEPFRIPADAFVCNPPYLSYKEFFKVDPEVRCHEPWKALVGGVSGLEFYHRIAEHIHKILVPGGVGWLEIGSN
QGESVKKIFRDKGISGCVFKDYAQLDRFFFLENQAGDAVSSGEVSGFSER

Sequences:

>Translated_290_residues
MKRLIKEASEYLLSRGIRFPQREAEDIMMDLLEVSSRGALHDIKLSSGERVSYWERVQKRGNRCPTAYIHGKVHFLGIEL
QVSPEVLIPRQETEIFVEKIIGYLQTHKEKKIFYDVCCGSGCIGLSVKKHCPHVHVVLSDICSQALAVAKSNAKRNDLIV
DFLCGDLFEPFRIPADAFVCNPPYLSYKEFFKVDPEVRCHEPWKALVGGVSGLEFYHRIAEHIHKILVPGGVGWLEIGSN
QGESVKKIFRDKGISGCVFKDYAQLDRFFFLENQAGDAVSSGEVSGFSER
>Mature_290_residues
MKRLIKEASEYLLSRGIRFPQREAEDIMMDLLEVSSRGALHDIKLSSGERVSYWERVQKRGNRCPTAYIHGKVHFLGIEL
QVSPEVLIPRQETEIFVEKIIGYLQTHKEKKIFYDVCCGSGCIGLSVKKHCPHVHVVLSDICSQALAVAKSNAKRNDLIV
DFLCGDLFEPFRIPADAFVCNPPYLSYKEFFKVDPEVRCHEPWKALVGGVSGLEFYHRIAEHIHKILVPGGVGWLEIGSN
QGESVKKIFRDKGISGCVFKDYAQLDRFFFLENQAGDAVSSGEVSGFSER

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=257, Percent_Identity=28.7937743190661, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI87082085, Length=202, Percent_Identity=34.1584158415842, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787463, Length=258, Percent_Identity=29.4573643410853, Blast_Score=84, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24582226, Length=247, Percent_Identity=31.9838056680162, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 32766; Mature: 32766

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00262 INSULIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLIKEASEYLLSRGIRFPQREAEDIMMDLLEVSSRGALHDIKLSSGERVSYWERVQKR
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHH
GNRCPTAYIHGKVHFLGIELQVSPEVLIPRQETEIFVEKIIGYLQTHKEKKIFYDVCCGS
CCCCCEEEEECEEEEEEEEEEECCCEECCCHHHHHHHHHHHHHHHHCCCHHEEEEEECCC
GCIGLSVKKHCPHVHVVLSDICSQALAVAKSNAKRNDLIVDFLCGDLFEPFRIPADAFVC
CCEECCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHCCCCCCEEE
NPPYLSYKEFFKVDPEVRCHEPWKALVGGVSGLEFYHRIAEHIHKILVPGGVGWLEIGSN
CCCCCCHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
QGESVKKIFRDKGISGCVFKDYAQLDRFFFLENQAGDAVSSGEVSGFSER
CCHHHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKRLIKEASEYLLSRGIRFPQREAEDIMMDLLEVSSRGALHDIKLSSGERVSYWERVQKR
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHH
GNRCPTAYIHGKVHFLGIELQVSPEVLIPRQETEIFVEKIIGYLQTHKEKKIFYDVCCGS
CCCCCEEEEECEEEEEEEEEEECCCEECCCHHHHHHHHHHHHHHHHCCCHHEEEEEECCC
GCIGLSVKKHCPHVHVVLSDICSQALAVAKSNAKRNDLIVDFLCGDLFEPFRIPADAFVC
CCEECCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHCCCCCCEEE
NPPYLSYKEFFKVDPEVRCHEPWKALVGGVSGLEFYHRIAEHIHKILVPGGVGWLEIGSN
CCCCCCHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
QGESVKKIFRDKGISGCVFKDYAQLDRFFFLENQAGDAVSSGEVSGFSER
CCHHHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]