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Identifier: 15834909

GI number: 15834909

Start: 346755

End: 348638

Strand: Reverse

Name: Not Available

Synonym: TC0289

Alternate gene names: 15834909

Gene position: 348638-346755 (Counterclockwise)

Preceding gene: 15834910

Following gene: 15834906

Centisome position: 32.49

GC content: 39.17

Gene sequence:

>1884_bases
ATGACGAGCAATTACATGAGTCGCTTATATTCCTTGAATAAGAGTCGTCGCATTCTTCATTCCTCCTATAAATTGCTGAA
AAATAAGAAAATGCTCTCTTATCCTGATACTCAGAAGGAATTACTTGAAATCTTAAAACAGCTTGAAGAAGCCATTTTGG
ATCAAAATAGAGAAGACGCCTCTCTTTTCGCTAAACAAGCTCAAGCTATTCAAAAACGATTCCCTCGGTCAAAAATACAG
GCAACTTTTGATCTCATCTATGCTTTAGCATTTGCTGCAGTTCTTGCTTTTTTAATTCGTCAATTCTGGTTTGAACTATA
TGAAGTTCCTACAGGATCAATGCGACCTACAATCCTTGAACAAGATCGGATTCTGGTCTCTAAAACTACATTTGGACTTC
GCCTGCCTTTTAGTAATGAAAGTATTGGCTATACACCGGAGACTATTACCCGAGGAGAACTTGTTGTCTTTACCGTTGGA
GACCTTCCCATCCCGAACGCTGACACCAAATATTTCGGAATTATACCTGGGAAAAAACGTTATATAAAGCGGTGCATGGG
CAAACCTGGAGACACTTTATACTTTTATGGGGGGAAAATTTATGGAATAGATCGTAATGGCGTCCCTATCACCACAAAAA
ATACAGAAAACCTTTATCACATCCCCTATATCTCTTTTGATGGCGTTACAGAAATCGTTAATCATTCAGATGATCAAACT
GATGTGATCTTTAACCAATTCCATACTCCCTGTGGGAAAATTTCCTTCCCCCACTATTCTCATGGGCAATTTTTCTACAA
AGATGCTTGGCACAAAGACACCCCCTATGCTTTAAAAGACCTTCATACCGAGCCTTTAAGCTATGCAGACCTATTTGGCA
TAAAAAATTTTGCAATGGTGCGTATTCTTACAAAAAAACAAGCTGCGCTTACTCACGTACTTTCTTCTCCTTTAGCAGAT
GCCTACTTAGAAATTGCACATACTCCTAATGTCTCTTATCCTCATCCGCATTTGCGTCCGTTAGAAACGCAACTTATCCC
CACTATTGAGCCTATGAAAACTCTCCTTCCTCTAAGGAAGGAGCACATGCATTTGATCCGTAATAACCTTACAACATCTC
GTTTCACAGTTATTGATGGATATGCCTACAAATATCAACCCACTCCAATTAATACTTCTGGCATAGCAAAAATATTTGCT
CTTCCAATGCCAAACATTCCGGATGGCTGTTATGAGTTTTCTAAAGGGGATGTGTTTAAAATTAGTATAGGAGGTTTCCG
CACTAAACTGAAACAACCCCATCCTTTGACGCAATTGAGCCATTCTCAGATTATTGATTTATTCAACTGCGGCATTAGTT
TTCATACAGTCTATATCCCCAAAAATCCTCAATACGCCCCTTTTCCTAATCGTTATGCTTTTTTCAATCAGGGAAACCTA
TTTGTTATGGATTCCCCAGTTTTCATTGACAGTGATCCTTCATTACAAAAATTTATCTTGGCGGAAAAAGAAAAGGAGCT
TCAGTCCTCTGAAGAAAAACCCTACATTGCCTTCATTGATCGAGGACCTCCCCCTGAATCTGCAGAAGAATTTACTTCTT
TTATTACAAATTTTGGACTTAAAATACCGGAAGGGCATGTGCTCGTTTTAGGAGATAATTGTCCTATGAGTGCAGACAGC
CGTGATTTTGGGTTCGTTCCCGTAGAAAACCTTTTAGGATCCCCGGTAGCTATTTTTTGGCCTATTAACCGTATAGGATC
ATTATCTTCTAGTATCACCCCGTTGAGCTTACCTGGTTATCTTGTTAATGGATTAGCCTTAGGAGCTCTTATTTACTTTG
TGGGTGCGTGGTATTATCGAAAGAATCACAGGTTATTCCCCTAA

Upstream 100 bases:

>100_bases
CGTATGAGTTCAGTAGATCTTGTTTTTAAAAATCTATGAGACTCCGCACAAGCAAGCAAAGAGGGAGCTCTCCTAACATG
AATATCGTTAAATTCTCCTA

Downstream 100 bases:

>100_bases
CAAATAACAAAAAAAAGAGGTCCTATAGGACCTCTTTTATATGTCATCTCAATGACCAATCACCTCTAGGGACAGTGAGA
CCGCGTGACCGTTAACATCC

Product: signal peptidase, putative

Products: NA

Alternate protein names: Signal Peptidase

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MTSNYMSRLYSLNKSRRILHSSYKLLKNKKMLSYPDTQKELLEILKQLEEAILDQNREDASLFAKQAQAIQKRFPRSKIQ
ATFDLIYALAFAAVLAFLIRQFWFELYEVPTGSMRPTILEQDRILVSKTTFGLRLPFSNESIGYTPETITRGELVVFTVG
DLPIPNADTKYFGIIPGKKRYIKRCMGKPGDTLYFYGGKIYGIDRNGVPITTKNTENLYHIPYISFDGVTEIVNHSDDQT
DVIFNQFHTPCGKISFPHYSHGQFFYKDAWHKDTPYALKDLHTEPLSYADLFGIKNFAMVRILTKKQAALTHVLSSPLAD
AYLEIAHTPNVSYPHPHLRPLETQLIPTIEPMKTLLPLRKEHMHLIRNNLTTSRFTVIDGYAYKYQPTPINTSGIAKIFA
LPMPNIPDGCYEFSKGDVFKISIGGFRTKLKQPHPLTQLSHSQIIDLFNCGISFHTVYIPKNPQYAPFPNRYAFFNQGNL
FVMDSPVFIDSDPSLQKFILAEKEKELQSSEEKPYIAFIDRGPPPESAEEFTSFITNFGLKIPEGHVLVLGDNCPMSADS
RDFGFVPVENLLGSPVAIFWPINRIGSLSSSITPLSLPGYLVNGLALGALIYFVGAWYYRKNHRLFP

Sequences:

>Translated_627_residues
MTSNYMSRLYSLNKSRRILHSSYKLLKNKKMLSYPDTQKELLEILKQLEEAILDQNREDASLFAKQAQAIQKRFPRSKIQ
ATFDLIYALAFAAVLAFLIRQFWFELYEVPTGSMRPTILEQDRILVSKTTFGLRLPFSNESIGYTPETITRGELVVFTVG
DLPIPNADTKYFGIIPGKKRYIKRCMGKPGDTLYFYGGKIYGIDRNGVPITTKNTENLYHIPYISFDGVTEIVNHSDDQT
DVIFNQFHTPCGKISFPHYSHGQFFYKDAWHKDTPYALKDLHTEPLSYADLFGIKNFAMVRILTKKQAALTHVLSSPLAD
AYLEIAHTPNVSYPHPHLRPLETQLIPTIEPMKTLLPLRKEHMHLIRNNLTTSRFTVIDGYAYKYQPTPINTSGIAKIFA
LPMPNIPDGCYEFSKGDVFKISIGGFRTKLKQPHPLTQLSHSQIIDLFNCGISFHTVYIPKNPQYAPFPNRYAFFNQGNL
FVMDSPVFIDSDPSLQKFILAEKEKELQSSEEKPYIAFIDRGPPPESAEEFTSFITNFGLKIPEGHVLVLGDNCPMSADS
RDFGFVPVENLLGSPVAIFWPINRIGSLSSSITPLSLPGYLVNGLALGALIYFVGAWYYRKNHRLFP
>Mature_626_residues
TSNYMSRLYSLNKSRRILHSSYKLLKNKKMLSYPDTQKELLEILKQLEEAILDQNREDASLFAKQAQAIQKRFPRSKIQA
TFDLIYALAFAAVLAFLIRQFWFELYEVPTGSMRPTILEQDRILVSKTTFGLRLPFSNESIGYTPETITRGELVVFTVGD
LPIPNADTKYFGIIPGKKRYIKRCMGKPGDTLYFYGGKIYGIDRNGVPITTKNTENLYHIPYISFDGVTEIVNHSDDQTD
VIFNQFHTPCGKISFPHYSHGQFFYKDAWHKDTPYALKDLHTEPLSYADLFGIKNFAMVRILTKKQAALTHVLSSPLADA
YLEIAHTPNVSYPHPHLRPLETQLIPTIEPMKTLLPLRKEHMHLIRNNLTTSRFTVIDGYAYKYQPTPINTSGIAKIFAL
PMPNIPDGCYEFSKGDVFKISIGGFRTKLKQPHPLTQLSHSQIIDLFNCGISFHTVYIPKNPQYAPFPNRYAFFNQGNLF
VMDSPVFIDSDPSLQKFILAEKEKELQSSEEKPYIAFIDRGPPPESAEEFTSFITNFGLKIPEGHVLVLGDNCPMSADSR
DFGFVPVENLLGSPVAIFWPINRIGSLSSSITPLSLPGYLVNGLALGALIYFVGAWYYRKNHRLFP

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.4.21.89

Molecular weight: Translated: 71322; Mature: 71191

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSNYMSRLYSLNKSRRILHSSYKLLKNKKMLSYPDTQKELLEILKQLEEAILDQNREDA
CCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHH
SLFAKQAQAIQKRFPRSKIQATFDLIYALAFAAVLAFLIRQFWFELYEVPTGSMRPTILE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEC
QDRILVSKTTFGLRLPFSNESIGYTPETITRGELVVFTVGDLPIPNADTKYFGIIPGKKR
CCCEEEEECCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCHHH
YIKRCMGKPGDTLYFYGGKIYGIDRNGVPITTKNTENLYHIPYISFDGVTEIVNHSDDQT
HHHHHCCCCCCEEEEECCEEEEECCCCCEEEECCCCCEEECCEECCCCHHHHHCCCCCCH
DVIFNQFHTPCGKISFPHYSHGQFFYKDAWHKDTPYALKDLHTEPLSYADLFGIKNFAMV
HHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHCCCCCCCHHHHHCCCCEEEE
RILTKKQAALTHVLSSPLADAYLEIAHTPNVSYPHPHLRPLETQLIPTIEPMKTLLPLRK
EEHHHHHHHHHHHHHCHHHHHHHEEECCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHH
EHMHLIRNNLTTSRFTVIDGYAYKYQPTPINTSGIAKIFALPMPNIPDGCYEFSKGDVFK
HHHHHHHHCCCCCEEEEEECEEEEEECCCCCCCCCCEEEECCCCCCCCHHHCCCCCCEEE
ISIGGFRTKLKQPHPLTQLSHSQIIDLFNCGISFHTVYIPKNPQYAPFPNRYAFFNQGNL
EEECCHHHHCCCCCCHHHCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCCE
FVMDSPVFIDSDPSLQKFILAEKEKELQSSEEKPYIAFIDRGPPPESAEEFTSFITNFGL
EEEECCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCC
KIPEGHVLVLGDNCPMSADSRDFGFVPVENLLGSPVAIFWPINRIGSLSSSITPLSLPGY
CCCCCCEEEECCCCCCCCCCCCCCCEEHHHHCCCCEEEEECHHHHCCCCCCCCCCCCCHH
LVNGLALGALIYFVGAWYYRKNHRLFP
HHHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure 
TSNYMSRLYSLNKSRRILHSSYKLLKNKKMLSYPDTQKELLEILKQLEEAILDQNREDA
CHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHH
SLFAKQAQAIQKRFPRSKIQATFDLIYALAFAAVLAFLIRQFWFELYEVPTGSMRPTILE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEC
QDRILVSKTTFGLRLPFSNESIGYTPETITRGELVVFTVGDLPIPNADTKYFGIIPGKKR
CCCEEEEECCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCHHH
YIKRCMGKPGDTLYFYGGKIYGIDRNGVPITTKNTENLYHIPYISFDGVTEIVNHSDDQT
HHHHHCCCCCCEEEEECCEEEEECCCCCEEEECCCCCEEECCEECCCCHHHHHCCCCCCH
DVIFNQFHTPCGKISFPHYSHGQFFYKDAWHKDTPYALKDLHTEPLSYADLFGIKNFAMV
HHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHCCCCCCCHHHHHCCCCEEEE
RILTKKQAALTHVLSSPLADAYLEIAHTPNVSYPHPHLRPLETQLIPTIEPMKTLLPLRK
EEHHHHHHHHHHHHHCHHHHHHHEEECCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHH
EHMHLIRNNLTTSRFTVIDGYAYKYQPTPINTSGIAKIFALPMPNIPDGCYEFSKGDVFK
HHHHHHHHCCCCCEEEEEECEEEEEECCCCCCCCCCEEEECCCCCCCCHHHCCCCCCEEE
ISIGGFRTKLKQPHPLTQLSHSQIIDLFNCGISFHTVYIPKNPQYAPFPNRYAFFNQGNL
EEECCHHHHCCCCCCHHHCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCCE
FVMDSPVFIDSDPSLQKFILAEKEKELQSSEEKPYIAFIDRGPPPESAEEFTSFITNFGL
EEEECCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCC
KIPEGHVLVLGDNCPMSADSRDFGFVPVENLLGSPVAIFWPINRIGSLSSSITPLSLPGY
CCCCCCEEEECCCCCCCCCCCCCCCEEHHHHCCCCEEEEECHHHHCCCCCCCCCCCCCHH
LVNGLALGALIYFVGAWYYRKNHRLFP
HHHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phospholipids; Triton X-100 [C]

Metal ions: NA

Kcat value (1/min): 523.8 [C]

Specific activity: NA

Km value (mM): 0.52 {Phe-Ser-Ala-Ser-Ala-Leu-Ala-Lys-Ile}} 0.33 {Phe-Ser-Ala-Ser-Ala-Leu-Ala-Lys-Ile}} 0.032 {pro-OmpA-nuclease} 0.0165 {pro-OmpA-nuclease} 1 {Phe-Ser-Ala-Ser-Ala-Leu-Ala-Lys-Ile-CONH2}} [C]

Substrates: NA

Specific reaction: NA

General reaction: Peptide bond hydrolysis [C]

Inhibitor: 1-Ethyl -3-(3-dimethyl aminopropyl) carbodiimide; beta-Lactams; Bromosuccinimide; Carboxyphenanthroline; Cholate; Cu2+; Deoxycholate; Diethyl dicarbonate; Dinitrophenol; Hg2+; Mg2+ most serine peptidases; NEM Cys; Phenyl glyoxal; SDS; Sodiumchloride [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA