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The map label for this gene is fumC

Identifier: 15834864

GI number: 15834864

Start: 283502

End: 284893

Strand: Direct

Name: fumC

Synonym: TC0244

Alternate gene names: 15834864

Gene position: 283502-284893 (Clockwise)

Preceding gene: 15834859

Following gene: 15834867

Centisome position: 26.42

GC content: 39.51

Gene sequence:

>1392_bases
ATGCGGCAAGAGAATGATAGTTTAGGGATTGTAATGGTTCCTGAAGATAAATTATTTGGTGCTCAGACGGGGAGATCAAA
AAATTTTTTCTCCTATGGAAAAGAATTGATGCCTATTGAGGTCATTCAGGCGTTGGTAAAAATTAAAAAATGTGCAGCTA
AGGCAAATGGAGATTTGCAGTGTCTCGATGCTAAAAGGCGGGATATGATTGTGGCTGCTTCGGATGAAATTCTTTCCGGA
GGATTAGAGGAACACTTCCCTTTAAAGGTATGGCAAACAGGAAGTGGAACCCAAAGCAATATGAATGTGAATGAGGTAAT
CGCTAATTTAGCGATTAAACGTCACGGAGGGGAGCTAGGAAGTAAAAATCCTGTGCATCCCAATGATCATGTGAATAAAT
CACAGTCTTCTAACGATGTTTTCCCTACGGCCATGCATATAGCTGCTGTGCAAAGTATAAAAGGTTCTTTAATACCGGCA
TTAGAACATTTACAAAAAAACCTTGATGCCAAAGCTTTAGAGTTTTCTAGAGACATTAAAATTGGAAGAACACATCTAAT
GGATGCCGTTCCAATGACTCTAGGGCAAGAGTTTTCTGGGTACAGTCATCAGTTACGTAGTTGTTTGGAGCGTATAGGTT
TTTCCTTAACCCATCTTTACGAATTAGCGATTGGAGGGACTGCTGTTGGAACAGGATTAAATGTTCCTGAAGGTTTTGTA
GATAAAGTAATTTATTATTTAAGGCAGGAAACGGGAGAGCCTTTTATTCCGGCTTCTAATTATTTTGCCGCATTGTCGAA
CCATGATGCTTTAGTGCAGGCTCATGGATCCTTAGCTGTTTTAGCTTGCTCTTTGATTAAGATCGCCACAGATTTGAGTT
TCTTAGGTTCAGGACCTCGTTGCGGGTTAGGGGAAATTTTTTTCCCAGAAAACGAGCCGGGATCTTCCATCATGCCTGGA
AAGATTAATCCTACTCAGAGTGAAGCTCTACAGATGGTGTGTTCTCAAGTTATTGGTAATAACCAATCCGTTATTTTCTC
AGGGACTAAAGGGAACTTTGAGCTAAATGTTATGAAGCCTGTGATTATTTATGATTTTTTGCAGTCTGTAAACTTGTTAT
CGGGAGCTATGAGATCCTTTGCGGATTATTTTGTTAGCGGATTAAAGGTGAATAGAGGACAACTGCAACAAAATGTGGAA
AGATCTTTGATGTTGGTTACGGCTTTAGCTCCTGTTTTAGGATATGATAAGTGTTCGAAGATTGCTCTAAAAGCTTTTCA
TGAAAATTTGAGTCTGAAAGAGGCCTGTGTATCATTAGGTTTTCTGTCTGAACAAGAGTTTGATACACATGTTGTTCCGG
GATTGATGCTAGGGAAAAGAGAAAGGGAATAG

Upstream 100 bases:

>100_bases
AAATCCTATCAAGGTGAGGATCATAAGTGCATAGCTAATAAACTTTTTCATGAGAGGAGAAAAGACTTCGTTATCGGAGG
AGCATAAGGAAAGAGAACAT

Downstream 100 bases:

>100_bases
ATTTTAAGAAGAGGGTATGAAAAACATCCTCTTCAATCCTAATCATGAAGAGGATGAGGAATCTCAGAATACCTGTTATG
CTATTGAGAAGATTTGCTCT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MRQENDSLGIVMVPEDKLFGAQTGRSKNFFSYGKELMPIEVIQALVKIKKCAAKANGDLQCLDAKRRDMIVAASDEILSG
GLEEHFPLKVWQTGSGTQSNMNVNEVIANLAIKRHGGELGSKNPVHPNDHVNKSQSSNDVFPTAMHIAAVQSIKGSLIPA
LEHLQKNLDAKALEFSRDIKIGRTHLMDAVPMTLGQEFSGYSHQLRSCLERIGFSLTHLYELAIGGTAVGTGLNVPEGFV
DKVIYYLRQETGEPFIPASNYFAALSNHDALVQAHGSLAVLACSLIKIATDLSFLGSGPRCGLGEIFFPENEPGSSIMPG
KINPTQSEALQMVCSQVIGNNQSVIFSGTKGNFELNVMKPVIIYDFLQSVNLLSGAMRSFADYFVSGLKVNRGQLQQNVE
RSLMLVTALAPVLGYDKCSKIALKAFHENLSLKEACVSLGFLSEQEFDTHVVPGLMLGKRERE

Sequences:

>Translated_463_residues
MRQENDSLGIVMVPEDKLFGAQTGRSKNFFSYGKELMPIEVIQALVKIKKCAAKANGDLQCLDAKRRDMIVAASDEILSG
GLEEHFPLKVWQTGSGTQSNMNVNEVIANLAIKRHGGELGSKNPVHPNDHVNKSQSSNDVFPTAMHIAAVQSIKGSLIPA
LEHLQKNLDAKALEFSRDIKIGRTHLMDAVPMTLGQEFSGYSHQLRSCLERIGFSLTHLYELAIGGTAVGTGLNVPEGFV
DKVIYYLRQETGEPFIPASNYFAALSNHDALVQAHGSLAVLACSLIKIATDLSFLGSGPRCGLGEIFFPENEPGSSIMPG
KINPTQSEALQMVCSQVIGNNQSVIFSGTKGNFELNVMKPVIIYDFLQSVNLLSGAMRSFADYFVSGLKVNRGQLQQNVE
RSLMLVTALAPVLGYDKCSKIALKAFHENLSLKEACVSLGFLSEQEFDTHVVPGLMLGKRERE
>Mature_463_residues
MRQENDSLGIVMVPEDKLFGAQTGRSKNFFSYGKELMPIEVIQALVKIKKCAAKANGDLQCLDAKRRDMIVAASDEILSG
GLEEHFPLKVWQTGSGTQSNMNVNEVIANLAIKRHGGELGSKNPVHPNDHVNKSQSSNDVFPTAMHIAAVQSIKGSLIPA
LEHLQKNLDAKALEFSRDIKIGRTHLMDAVPMTLGQEFSGYSHQLRSCLERIGFSLTHLYELAIGGTAVGTGLNVPEGFV
DKVIYYLRQETGEPFIPASNYFAALSNHDALVQAHGSLAVLACSLIKIATDLSFLGSGPRCGLGEIFFPENEPGSSIMPG
KINPTQSEALQMVCSQVIGNNQSVIFSGTKGNFELNVMKPVIIYDFLQSVNLLSGAMRSFADYFVSGLKVNRGQLQQNVE
RSLMLVTALAPVLGYDKCSKIALKAFHENLSLKEACVSLGFLSEQEFDTHVVPGLMLGKRERE

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=54.880694143167, Blast_Score=488, Evalue=1e-138,
Organism=Escherichia coli, GI1787896, Length=458, Percent_Identity=54.1484716157205, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI87082375, Length=451, Percent_Identity=39.0243902439024, Blast_Score=306, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17553882, Length=462, Percent_Identity=54.7619047619048, Blast_Score=496, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=53.2110091743119, Blast_Score=348, Evalue=5e-96,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=53.6796536796537, Blast_Score=483, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=54.3290043290043, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=54.3290043290043, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=53.7796976241901, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=53.3622559652928, Blast_Score=475, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=46.4208242950108, Blast_Score=413, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FUMC_CHLMU (Q9PL64)

Other databases:

- EMBL:   AE002160
- PIR:   B81725
- RefSeq:   NP_296623.1
- ProteinModelPortal:   Q9PL64
- SMR:   Q9PL64
- GeneID:   1246413
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0244
- TIGR:   TC_0244
- HOGENOM:   HBG284369
- OMA:   RIEKDTM
- PhylomeDB:   Q9PL64
- ProtClustDB:   PRK00485
- BioCyc:   CMUR243161:TC_0244-MONOMER
- BRENDA:   4.2.1.2
- HAMAP:   MF_00743
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00979

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.2.1.2

Molecular weight: Translated: 50429; Mature: 50429

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: BINDING 97-97

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQENDSLGIVMVPEDKLFGAQTGRSKNFFSYGKELMPIEVIQALVKIKKCAAKANGDLQ
CCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEE
CLDAKRRDMIVAASDEILSGGLEEHFPLKVWQTGSGTQSNMNVNEVIANLAIKRHGGELG
EECCCCCCEEEEECHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCC
SKNPVHPNDHVNKSQSSNDVFPTAMHIAAVQSIKGSLIPALEHLQKNLDAKALEFSRDIK
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHCCCH
IGRTHLMDAVPMTLGQEFSGYSHQLRSCLERIGFSLTHLYELAIGGTAVGTGLNVPEGFV
HHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCHHHH
DKVIYYLRQETGEPFIPASNYFAALSNHDALVQAHGSLAVLACSLIKIATDLSFLGSGPR
HHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCC
CGLGEIFFPENEPGSSIMPGKINPTQSEALQMVCSQVIGNNQSVIFSGTKGNFELNVMKP
CCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECH
VIIYDFLQSVNLLSGAMRSFADYFVSGLKVNRGQLQQNVERSLMLVTALAPVLGYDKCSK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
IALKAFHENLSLKEACVSLGFLSEQEFDTHVVPGLMLGKRERE
HHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHCCHHHHCCCCCC
>Mature Secondary Structure
MRQENDSLGIVMVPEDKLFGAQTGRSKNFFSYGKELMPIEVIQALVKIKKCAAKANGDLQ
CCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEE
CLDAKRRDMIVAASDEILSGGLEEHFPLKVWQTGSGTQSNMNVNEVIANLAIKRHGGELG
EECCCCCCEEEEECHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCC
SKNPVHPNDHVNKSQSSNDVFPTAMHIAAVQSIKGSLIPALEHLQKNLDAKALEFSRDIK
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHCCCH
IGRTHLMDAVPMTLGQEFSGYSHQLRSCLERIGFSLTHLYELAIGGTAVGTGLNVPEGFV
HHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCHHHH
DKVIYYLRQETGEPFIPASNYFAALSNHDALVQAHGSLAVLACSLIKIATDLSFLGSGPR
HHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCC
CGLGEIFFPENEPGSSIMPGKINPTQSEALQMVCSQVIGNNQSVIFSGTKGNFELNVMKP
CCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECH
VIIYDFLQSVNLLSGAMRSFADYFVSGLKVNRGQLQQNVERSLMLVTALAPVLGYDKCSK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
IALKAFHENLSLKEACVSLGFLSEQEFDTHVVPGLMLGKRERE
HHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935