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The map label for this gene is pheS

Identifier: 15834844

GI number: 15834844

Start: 262345

End: 263370

Strand: Direct

Name: pheS

Synonym: TC0224

Alternate gene names: 15834844

Gene position: 262345-263370 (Clockwise)

Preceding gene: 15834843

Following gene: 15834845

Centisome position: 24.45

GC content: 42.5

Gene sequence:

>1026_bases
ATGACAATTCAAGAGGAACTTGAGGCTGTTAAGCAGCAATTTAGTTGTGATTTAAGCCTTGTGCATTCTTCTAAAGATCT
TTTTGATTTGAAAGTAAAGTACCTTGGTAAGAAGGGAATCTTTCGAGGGTTTGCGGATCAGTTGAGGGAGTGTCCTGTAG
AGCAAAAAGCGACTATTGGAGCTTCCATCAATGCTTGTAAGCAGTACATTGAGGAAGTTTTACTTGAAAAAAGTCAGGTC
ATTTTGGCCAAAGAAGAGGCAGAAGAGTTCCTTAAAGAGAAAGTTGATGTTAGTTTGCCCGGAGAGGATGCTCCTCTTGG
GGGCAAGCATATTATCAAGAAAGTTCTCGATGATGTTGTAGACATTTTTGTTCGTTTTGGGTTTTGTGTCCGGGAAGCTC
CTAATATTGAAAGTGAAAAGAATAACTTTTCTCTGCTTAATTTTGAGGAAGATCATCCCGCTAGACAGATGCAGGATACT
TTTTATCTCGATCCGGTTACTGTCTTGCGTACACATACTTCGAACGTGCAGTCTCGGGAGTTAGCGAGAAATAAACCTCC
TGTTAGAGTCGTCGCTCCAGGAGAGTGTTTCCGTAACGAAGACATCTCTGCACGTTCTCATGTGACCTTTCATCAAGTAG
AGGCTTTTCATGTAGACAGAGATGTTTCTTTTTCGGACTTGACATCGATGTTGTCGGGGTTTTACCATATCTTCTTTGGT
CGTAAGGTAGAGTTGCGGTATAGACACAGCTACTTCCCTTTTGTGGAGCCAGGGATTGAGGTAGATATTTCTTGCGAGTG
CCGTGGGGCTGGGTGTTCTTTATGTAAACACTCGGGTTGGTTAGAGGTTGCTGGTGCTGGGATGATTCATCCGAACGTCT
TGCGTCAAGCAAATATTGATCCGGAAGAATATTCTGGATATGCTTTGGGAATGGGTATAGAGCGTCTTGCGATGCTTAAG
TACGGAATTTCCGATATTCGATTGTTTAGCGAGAACGATTTGCGGTTTTTGCGACAATTTTCTTAA

Upstream 100 bases:

>100_bases
GATGTTGTCTGAGATGGCTATCCATGATCCTCAGGGATTTGCTTTAGTAGCTGCTCAAGCTAAACTCGCTTTGGAAGCTT
CTATTCAGGGATAAAGGTTT

Downstream 100 bases:

>100_bases
GGAAGAATGGCAGAGCGGTTTAATGCACCTGTCTTGAAAACAGGAGACCTGAAAGGGTCCGGGGGTTCGAATCCCTCTTC
TTCCGATTCTTTTTGAAGAA

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTIQEELEAVKQQFSCDLSLVHSSKDLFDLKVKYLGKKGIFRGFADQLRECPVEQKATIGASINACKQYIEEVLLEKSQV
ILAKEEAEEFLKEKVDVSLPGEDAPLGGKHIIKKVLDDVVDIFVRFGFCVREAPNIESEKNNFSLLNFEEDHPARQMQDT
FYLDPVTVLRTHTSNVQSRELARNKPPVRVVAPGECFRNEDISARSHVTFHQVEAFHVDRDVSFSDLTSMLSGFYHIFFG
RKVELRYRHSYFPFVEPGIEVDISCECRGAGCSLCKHSGWLEVAGAGMIHPNVLRQANIDPEEYSGYALGMGIERLAMLK
YGISDIRLFSENDLRFLRQFS

Sequences:

>Translated_341_residues
MTIQEELEAVKQQFSCDLSLVHSSKDLFDLKVKYLGKKGIFRGFADQLRECPVEQKATIGASINACKQYIEEVLLEKSQV
ILAKEEAEEFLKEKVDVSLPGEDAPLGGKHIIKKVLDDVVDIFVRFGFCVREAPNIESEKNNFSLLNFEEDHPARQMQDT
FYLDPVTVLRTHTSNVQSRELARNKPPVRVVAPGECFRNEDISARSHVTFHQVEAFHVDRDVSFSDLTSMLSGFYHIFFG
RKVELRYRHSYFPFVEPGIEVDISCECRGAGCSLCKHSGWLEVAGAGMIHPNVLRQANIDPEEYSGYALGMGIERLAMLK
YGISDIRLFSENDLRFLRQFS
>Mature_340_residues
TIQEELEAVKQQFSCDLSLVHSSKDLFDLKVKYLGKKGIFRGFADQLRECPVEQKATIGASINACKQYIEEVLLEKSQVI
LAKEEAEEFLKEKVDVSLPGEDAPLGGKHIIKKVLDDVVDIFVRFGFCVREAPNIESEKNNFSLLNFEEDHPARQMQDTF
YLDPVTVLRTHTSNVQSRELARNKPPVRVVAPGECFRNEDISARSHVTFHQVEAFHVDRDVSFSDLTSMLSGFYHIFFGR
KVELRYRHSYFPFVEPGIEVDISCECRGAGCSLCKHSGWLEVAGAGMIHPNVLRQANIDPEEYSGYALGMGIERLAMLKY
GISDIRLFSENDLRFLRQFS

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI5729820, Length=256, Percent_Identity=31.25, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4758340, Length=269, Percent_Identity=29.7397769516729, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1788007, Length=314, Percent_Identity=42.9936305732484, Blast_Score=272, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI32566635, Length=257, Percent_Identity=27.6264591439689, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17508957, Length=269, Percent_Identity=27.1375464684015, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI32563657, Length=269, Percent_Identity=27.1375464684015, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321087, Length=272, Percent_Identity=28.3088235294118, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6325304, Length=101, Percent_Identity=36.6336633663366, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17137424, Length=263, Percent_Identity=27.3764258555133, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI18858079, Length=273, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d [H]

EC number: =6.1.1.20 [H]

Molecular weight: Translated: 38782; Mature: 38650

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS50862 AA_TRNA_LIGASE_II ; PS00197 2FE2S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQEELEAVKQQFSCDLSLVHSSKDLFDLKVKYLGKKGIFRGFADQLRECPVEQKATIG
CCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHCC
ASINACKQYIEEVLLEKSQVILAKEEAEEFLKEKVDVSLPGEDAPLGGKHIIKKVLDDVV
CCHHHHHHHHHHHHHCCHHEEEEHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
DIFVRFGFCVREAPNIESEKNNFSLLNFEEDHPARQMQDTFYLDPVTVLRTHTSNVQSRE
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHCCCCCHHHH
LARNKPPVRVVAPGECFRNEDISARSHVTFHQVEAFHVDRDVSFSDLTSMLSGFYHIFFG
HHCCCCCEEEECCCHHHCCCCCCCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHHHHC
RKVELRYRHSYFPFVEPGIEVDISCECRGAGCSLCKHSGWLEVAGAGMIHPNVLRQANID
CEEEEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHCCCCEEECCCCCCCHHHHHHCCCC
PEEYSGYALGMGIERLAMLKYGISDIRLFSENDLRFLRQFS
HHHHCCEEECHHHHHHHHHHHCHHHEEEECCCHHHHHHHCC
>Mature Secondary Structure 
TIQEELEAVKQQFSCDLSLVHSSKDLFDLKVKYLGKKGIFRGFADQLRECPVEQKATIG
CHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHCC
ASINACKQYIEEVLLEKSQVILAKEEAEEFLKEKVDVSLPGEDAPLGGKHIIKKVLDDVV
CCHHHHHHHHHHHHHCCHHEEEEHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
DIFVRFGFCVREAPNIESEKNNFSLLNFEEDHPARQMQDTFYLDPVTVLRTHTSNVQSRE
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHCCCCCHHHH
LARNKPPVRVVAPGECFRNEDISARSHVTFHQVEAFHVDRDVSFSDLTSMLSGFYHIFFG
HHCCCCCEEEECCCHHHCCCCCCCCCCCCHHHHEEEECCCCCCHHHHHHHHHHHHHHHHC
RKVELRYRHSYFPFVEPGIEVDISCECRGAGCSLCKHSGWLEVAGAGMIHPNVLRQANID
CEEEEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHCCCCEEECCCCCCCHHHHHHCCCC
PEEYSGYALGMGIERLAMLKYGISDIRLFSENDLRFLRQFS
HHHHCCEEECHHHHHHHHHHHCHHHEEEECCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA