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The map label for this gene is htrA

Identifier: 15834830

GI number: 15834830

Start: 246105

End: 247598

Strand: Direct

Name: htrA

Synonym: TC0210

Alternate gene names: 15834830

Gene position: 246105-247598 (Clockwise)

Preceding gene: 15834829

Following gene: 15834831

Centisome position: 22.94

GC content: 41.63

Gene sequence:

>1494_bases
ATGATGAAAAGATTATTATGTGTGTTGCTATCGACATCAGTTTTCTCTTCGCCCATGTTGGGCTATAGTGCGCCAAAGAA
AGATTCCAGTACTGGCATTTGTCTTGCAGCATCTCAAAGTGATCGGGAACTTTCCCAAGAAGATTTGCTAAAAGAAGTGT
CTAGAGGATTTTCCAAAGTCGCTGCTCAGGCAACTCCAGGAGTTGTGTATATAGAAAATTTTCCTAAAACTGGGAGTCAA
GCTATTGCTTCTCCTGGGAATAAAAGGGGTTTTCAAGAGAATCCCTTTGATTATTTCAATGATGAGTTTTTCAATCGATT
TTTTGGTTTACCCTCGCATAGAGAGCAGCCTCGTCCCCAACAGCGTGATGCTGTAAGAGGAACAGGTTTTATTGTGTCAG
AAGATGGGTACGTTGTGACCAACCATCACGTAGTGGAAGATGCGGGGAAAATTCATGTTACTTTACACGATGGACAAAAA
TACACCGCAAAAATCATAGGATTAGATCCTAAAACGGATCTCGCTGTGATTAAGATCCAAGCAAAAAATCTCCCTTTTTT
AACTTTTGGAAACTCTGATCAGCTTCAGATAGGGGATTGGTCAATAGCCATTGGAAATCCTTTCGGATTACAAGCCACAG
TAACCGTTGGCGTGATTAGTGCTAAGGGAAGAAACCAATTACATATTGTTGATTTTGAAGATTTTATTCAGACGGATGCA
GCAATTAATCCCGGGAATTCAGGTGGTCCATTATTGAACATTGATGGACAGGTTATTGGAGTGAATACAGCAATCGTTAG
CGGTAGCGGGGGATACATTGGAATAGGATTTGCCATTCCTAGCTTAATGGCTAAACGAGTTATTGACCAACTCATTAGCG
ATGGACAGGTGACGAGAGGATTTTTAGGAGTAACCTTACAGCCTATTGATTCGGAGCTTGCCGCTTGTTACAAATTAGAA
AAGGTGTACGGAGCCTTGATTACGGATGTTGTTAAGGGATCTCCTGCAGAAAAAGCAGGTTTGCGCCAGGAAGATGTCAT
TGTTGCTTACAATGGGAAAGAAGTGGAGTCTTTGAGTGCTTTACGTAATGCGATTTCTTTGATGATGCCAGGGACTCGTG
TTGTCTTAAAAGTTGTGCGTGAAGGGAAATTCATTGAAATACCTGTCACTGTTACACAAATTCCTGCGGAGGATGGGGTA
TCTGCTCTTCAAAAAATGGGAGTTCGGGTACAGAATCTTACTCCAGAGATATGCAAGAAACTAGGATTAGCGTCTGATAC
TCGAGGGATTTTTGTAGTGTCCGTAGAAGCTGGTTCTCCTGCAGCTTCTGCAGGAGTGGTTCCAGGACAACTTATTCTGG
CTGTAAACAGACAGAGAGTTTCTTCTGTTGAAGAATTGAATCAGGTCTTGAAGAATGCAAAAGGAGAGAATGTTCTCCTT
ATGGTTTCTCAAGGAGAAGTCATTCGATTCGTTGTTTTAAAGTCTGATGAATAG

Upstream 100 bases:

>100_bases
ATCATTAGATTTTGTATGCTGCATAACTGCTCTTCATAGTGCATAATAATGCATAAAATAAAAAAAGGCCTAGACGCCTG
GATCGCTTATCAAGGAAAAG

Downstream 100 bases:

>100_bases
TGCAGACTTTTGTTCTAAAAGATCTAGAGAAAGGGGGGGCTCGATTGAGCCCCTTTTCTTTTTATAAGAGAAAAAATTAG
AAAGAATATTTGTGTGGATA

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MMKRLLCVLLSTSVFSSPMLGYSAPKKDSSTGICLAASQSDRELSQEDLLKEVSRGFSKVAAQATPGVVYIENFPKTGSQ
AIASPGNKRGFQENPFDYFNDEFFNRFFGLPSHREQPRPQQRDAVRGTGFIVSEDGYVVTNHHVVEDAGKIHVTLHDGQK
YTAKIIGLDPKTDLAVIKIQAKNLPFLTFGNSDQLQIGDWSIAIGNPFGLQATVTVGVISAKGRNQLHIVDFEDFIQTDA
AINPGNSGGPLLNIDGQVIGVNTAIVSGSGGYIGIGFAIPSLMAKRVIDQLISDGQVTRGFLGVTLQPIDSELAACYKLE
KVYGALITDVVKGSPAEKAGLRQEDVIVAYNGKEVESLSALRNAISLMMPGTRVVLKVVREGKFIEIPVTVTQIPAEDGV
SALQKMGVRVQNLTPEICKKLGLASDTRGIFVVSVEAGSPAASAGVVPGQLILAVNRQRVSSVEELNQVLKNAKGENVLL
MVSQGEVIRFVVLKSDE

Sequences:

>Translated_497_residues
MMKRLLCVLLSTSVFSSPMLGYSAPKKDSSTGICLAASQSDRELSQEDLLKEVSRGFSKVAAQATPGVVYIENFPKTGSQ
AIASPGNKRGFQENPFDYFNDEFFNRFFGLPSHREQPRPQQRDAVRGTGFIVSEDGYVVTNHHVVEDAGKIHVTLHDGQK
YTAKIIGLDPKTDLAVIKIQAKNLPFLTFGNSDQLQIGDWSIAIGNPFGLQATVTVGVISAKGRNQLHIVDFEDFIQTDA
AINPGNSGGPLLNIDGQVIGVNTAIVSGSGGYIGIGFAIPSLMAKRVIDQLISDGQVTRGFLGVTLQPIDSELAACYKLE
KVYGALITDVVKGSPAEKAGLRQEDVIVAYNGKEVESLSALRNAISLMMPGTRVVLKVVREGKFIEIPVTVTQIPAEDGV
SALQKMGVRVQNLTPEICKKLGLASDTRGIFVVSVEAGSPAASAGVVPGQLILAVNRQRVSSVEELNQVLKNAKGENVLL
MVSQGEVIRFVVLKSDE
>Mature_497_residues
MMKRLLCVLLSTSVFSSPMLGYSAPKKDSSTGICLAASQSDRELSQEDLLKEVSRGFSKVAAQATPGVVYIENFPKTGSQ
AIASPGNKRGFQENPFDYFNDEFFNRFFGLPSHREQPRPQQRDAVRGTGFIVSEDGYVVTNHHVVEDAGKIHVTLHDGQK
YTAKIIGLDPKTDLAVIKIQAKNLPFLTFGNSDQLQIGDWSIAIGNPFGLQATVTVGVISAKGRNQLHIVDFEDFIQTDA
AINPGNSGGPLLNIDGQVIGVNTAIVSGSGGYIGIGFAIPSLMAKRVIDQLISDGQVTRGFLGVTLQPIDSELAACYKLE
KVYGALITDVVKGSPAEKAGLRQEDVIVAYNGKEVESLSALRNAISLMMPGTRVVLKVVREGKFIEIPVTVTQIPAEDGV
SALQKMGVRVQNLTPEICKKLGLASDTRGIFVVSVEAGSPAASAGVVPGQLILAVNRQRVSSVEELNQVLKNAKGENVLL
MVSQGEVIRFVVLKSDE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains

Homologues:

Organism=Homo sapiens, GI4506141, Length=307, Percent_Identity=39.413680781759, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI24308541, Length=254, Percent_Identity=40.5511811023622, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI22129776, Length=276, Percent_Identity=38.768115942029, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI7019477, Length=258, Percent_Identity=39.1472868217054, Blast_Score=147, Evalue=3e-35,
Organism=Escherichia coli, GI1786356, Length=370, Percent_Identity=41.6216216216216, Blast_Score=279, Evalue=4e-76,
Organism=Escherichia coli, GI1789629, Length=397, Percent_Identity=39.2947103274559, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1789630, Length=299, Percent_Identity=36.7892976588629, Blast_Score=180, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24646839, Length=264, Percent_Identity=34.469696969697, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DEGP_CHLMU (Q9PL97)

Other databases:

- EMBL:   AE002160
- PIR:   B81728
- RefSeq:   NP_296589.1
- ProteinModelPortal:   Q9PL97
- SMR:   Q9PL97
- MEROPS:   S01.480
- GeneID:   1246336
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0210
- TIGR:   TC_0210
- HOGENOM:   HBG585708
- OMA:   NAREIRV
- PhylomeDB:   Q9PL97
- ProtClustDB:   CLSK871616
- BioCyc:   CMUR243161:TC_0210-MONOMER
- GO:   GO:0006508
- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940
- PRINTS:   PR00834
- SMART:   SM00228
- TIGRFAMs:   TIGR02037

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin; SSF50156 PDZ; SSF50494 Pept_Ser_Cys

EC number: 3.4.21.-

Molecular weight: Translated: 53295; Mature: 53295

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50106 PDZ

Important sites: ACT_SITE 143-143 ACT_SITE 173-173 ACT_SITE 247-247

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKRLLCVLLSTSVFSSPMLGYSAPKKDSSTGICLAASQSDRELSQEDLLKEVSRGFSKV
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
AAQATPGVVYIENFPKTGSQAIASPGNKRGFQENPFDYFNDEFFNRFFGLPSHREQPRPQ
HHHCCCCEEEEECCCCCCCHHHCCCCCCCCCCCCCCHHCCHHHHHHHCCCCCCCCCCCCC
QRDAVRGTGFIVSEDGYVVTNHHVVEDAGKIHVTLHDGQKYTAKIIGLDPKTDLAVIKIQ
HHHCCCCCEEEEECCCEEEECCEEECCCCEEEEEEECCCEEEEEEEECCCCCCEEEEEEE
AKNLPFLTFGNSDQLQIGDWSIAIGNPFGLQATVTVGVISAKGRNQLHIVDFEDFIQTDA
ECCCCEEEECCCCCEEECCEEEEECCCCCCEEEEEEEEEECCCCCEEEEEEHHHHHHCCC
AINPGNSGGPLLNIDGQVIGVNTAIVSGSGGYIGIGFAIPSLMAKRVIDQLISDGQVTRG
CCCCCCCCCCEEEECCEEEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCEECE
FLGVTLQPIDSELAACYKLEKVYGALITDVVKGSPAEKAGLRQEDVIVAYNGKEVESLSA
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEEEEECCCCHHHHHH
LRNAISLMMPGTRVVLKVVREGKFIEIPVTVTQIPAEDGVSALQKMGVRVQNLTPEICKK
HHHHHHHHCCCHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHCCEEECCCHHHHHH
LGLASDTRGIFVVSVEAGSPAASAGVVPGQLILAVNRQRVSSVEELNQVLKNAKGENVLL
CCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCEEEE
MVSQGEVIRFVVLKSDE
EEECCCEEEEEEEECCC
>Mature Secondary Structure
MMKRLLCVLLSTSVFSSPMLGYSAPKKDSSTGICLAASQSDRELSQEDLLKEVSRGFSKV
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
AAQATPGVVYIENFPKTGSQAIASPGNKRGFQENPFDYFNDEFFNRFFGLPSHREQPRPQ
HHHCCCCEEEEECCCCCCCHHHCCCCCCCCCCCCCCHHCCHHHHHHHCCCCCCCCCCCCC
QRDAVRGTGFIVSEDGYVVTNHHVVEDAGKIHVTLHDGQKYTAKIIGLDPKTDLAVIKIQ
HHHCCCCCEEEEECCCEEEECCEEECCCCEEEEEEECCCEEEEEEEECCCCCCEEEEEEE
AKNLPFLTFGNSDQLQIGDWSIAIGNPFGLQATVTVGVISAKGRNQLHIVDFEDFIQTDA
ECCCCEEEECCCCCEEECCEEEEECCCCCCEEEEEEEEEECCCCCEEEEEEHHHHHHCCC
AINPGNSGGPLLNIDGQVIGVNTAIVSGSGGYIGIGFAIPSLMAKRVIDQLISDGQVTRG
CCCCCCCCCCEEEECCEEEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCEECE
FLGVTLQPIDSELAACYKLEKVYGALITDVVKGSPAEKAGLRQEDVIVAYNGKEVESLSA
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEEEEECCCCHHHHHH
LRNAISLMMPGTRVVLKVVREGKFIEIPVTVTQIPAEDGVSALQKMGVRVQNLTPEICKK
HHHHHHHHCCCHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHCCEEECCCHHHHHH
LGLASDTRGIFVVSVEAGSPAASAGVVPGQLILAVNRQRVSSVEELNQVLKNAKGENVLL
CCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCEEEE
MVSQGEVIRFVVLKSDE
EEECCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935