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The map label for this gene is sucD

Identifier: 15834829

GI number: 15834829

Start: 245087

End: 245962

Strand: Direct

Name: sucD

Synonym: TC0209

Alternate gene names: 15834829

Gene position: 245087-245962 (Clockwise)

Preceding gene: 15834828

Following gene: 15834830

Centisome position: 22.84

GC content: 44.52

Gene sequence:

>876_bases
GTGTTAGAATTATTAAACAAAGATCTGCCGATTATCACGCAGGGTATTACGGGGAAAGCAGGATCTTTTCATACCACTCA
ATGTGTCGCCTATGGATCTAACTTTGTGGGTGGCGTTACTCCGGGTAAAGGAGGGACTCAGTTTTTAGATTTGCCTATTT
TTGACTCTGTTTTAGAGGCAAAGCAAGCAACGGGATGCCGTGCTTCAATGATTTTTGTTCCTCCTCCGTTCGCTGCAGAG
GCTATTTTTGAAGCTGAAGATGCGGGGATTGAGTTGATCGTATGTATAACAGAAGGAATCCCTGTACAAGATATGTTGGC
AGTGAATTCTCTTATGGAGAAGAGTTCTTGCCGTTTAGTTGGCCCTAATTGTCCCGGAGTGATTAAGCCCGGGGCTTGTA
AAATTGGCATTATGCCAGGGTATATTCACTTACCAGGAAATGTTGGAGTCATTTCTAGATCTGGGACATTAACTTACGAA
GCGGTTTGGCAGTTAACACAGAGAAAGATTGGACAAAGTGTATGTATTGGCATTGGGGGAGATCCCCTAAATGGGACTTC
TTTCATTGATGTTCTCCAGGAGCTTGAAAAGGATGAACAGACTGAGGCTATTCTTATGATTGGAGAAATAGGAGGTAGTG
CCGAAGAAGATGCTGCTGATTGGATAAGCCAGCACTGTAGTAAGCCTGTGATTGCATTTATTGCTGGAGCTACGGCTCCG
AAAGGGAAACGTATGGGGCATGCGGGTGCAATTATTTCAGGGAATAGTGGGGATGCTTTCAGTAAACAACGTGCTTTAAG
AGAGGCTGGAGTTGTCGTTGTGGAATCTCCTGCACTTATAGGAGAGGCTGTTGCGTCTGTTCTGAATTCCCATTAG

Upstream 100 bases:

>100_bases
AAATCATTCTTAGATCAGGAATTCCTTGTGAATTTGTTGCCTCTATGAGTGAGGGGGCTGAGCTCGCAGTGAAATTAAGT
CGTTAGCCTGGGGAGAGACT

Downstream 100 bases:

>100_bases
TAGTTTGGAGAAGGAATTAGCAGAGTAGTCTCCTTGATTTGCATCATTAGATTTTGTATGCTGCATAACTGCTCTTCATA
GTGCATAATAATGCATAAAA

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MLELLNKDLPIITQGITGKAGSFHTTQCVAYGSNFVGGVTPGKGGTQFLDLPIFDSVLEAKQATGCRASMIFVPPPFAAE
AIFEAEDAGIELIVCITEGIPVQDMLAVNSLMEKSSCRLVGPNCPGVIKPGACKIGIMPGYIHLPGNVGVISRSGTLTYE
AVWQLTQRKIGQSVCIGIGGDPLNGTSFIDVLQELEKDEQTEAILMIGEIGGSAEEDAADWISQHCSKPVIAFIAGATAP
KGKRMGHAGAIISGNSGDAFSKQRALREAGVVVVESPALIGEAVASVLNSH

Sequences:

>Translated_291_residues
MLELLNKDLPIITQGITGKAGSFHTTQCVAYGSNFVGGVTPGKGGTQFLDLPIFDSVLEAKQATGCRASMIFVPPPFAAE
AIFEAEDAGIELIVCITEGIPVQDMLAVNSLMEKSSCRLVGPNCPGVIKPGACKIGIMPGYIHLPGNVGVISRSGTLTYE
AVWQLTQRKIGQSVCIGIGGDPLNGTSFIDVLQELEKDEQTEAILMIGEIGGSAEEDAADWISQHCSKPVIAFIAGATAP
KGKRMGHAGAIISGNSGDAFSKQRALREAGVVVVESPALIGEAVASVLNSH
>Mature_291_residues
MLELLNKDLPIITQGITGKAGSFHTTQCVAYGSNFVGGVTPGKGGTQFLDLPIFDSVLEAKQATGCRASMIFVPPPFAAE
AIFEAEDAGIELIVCITEGIPVQDMLAVNSLMEKSSCRLVGPNCPGVIKPGACKIGIMPGYIHLPGNVGVISRSGTLTYE
AVWQLTQRKIGQSVCIGIGGDPLNGTSFIDVLQELEKDEQTEAILMIGEIGGSAEEDAADWISQHCSKPVIAFIAGATAP
KGKRMGHAGAIISGNSGDAFSKQRALREAGVVVVESPALIGEAVASVLNSH

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=285, Percent_Identity=60, Blast_Score=291, Evalue=4e-79,
Organism=Homo sapiens, GI38569421, Length=212, Percent_Identity=31.6037735849057, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI38569423, Length=212, Percent_Identity=31.6037735849057, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1786949, Length=289, Percent_Identity=60.8996539792388, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17550194, Length=289, Percent_Identity=57.0934256055363, Blast_Score=310, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17553126, Length=290, Percent_Identity=56.8965517241379, Blast_Score=306, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI17557344, Length=218, Percent_Identity=31.1926605504587, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17551266, Length=223, Percent_Identity=30.9417040358744, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324716, Length=290, Percent_Identity=52.7586206896552, Blast_Score=278, Evalue=7e-76,
Organism=Drosophila melanogaster, GI28574296, Length=283, Percent_Identity=59.0106007067138, Blast_Score=299, Evalue=1e-81,
Organism=Drosophila melanogaster, GI21356559, Length=285, Percent_Identity=52.6315789473684, Blast_Score=298, Evalue=4e-81,
Organism=Drosophila melanogaster, GI281363477, Length=223, Percent_Identity=30.0448430493274, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281363475, Length=223, Percent_Identity=30.0448430493274, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281363473, Length=223, Percent_Identity=30.0448430493274, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30262; Mature: 30262

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELLNKDLPIITQGITGKAGSFHTTQCVAYGSNFVGGVTPGKGGTQFLDLPIFDSVLEA
CCCCCCCCCCEEECCCCCCCCCCCHHHEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHH
KQATGCRASMIFVPPPFAAEAIFEAEDAGIELIVCITEGIPVQDMLAVNSLMEKSSCRLV
HHCCCCEEEEEEECCCCHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCEEE
GPNCPGVIKPGACKIGIMPGYIHLPGNVGVISRSGTLTYEAVWQLTQRKIGQSVCIGIGG
CCCCCCCCCCCCEEEEECCCEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECC
DPLNGTSFIDVLQELEKDEQTEAILMIGEIGGSAEEDAADWISQHCSKPVIAFIAGATAP
CCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCC
KGKRMGHAGAIISGNSGDAFSKQRALREAGVVVVESPALIGEAVASVLNSH
CCCCCCCCCEEEECCCCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLELLNKDLPIITQGITGKAGSFHTTQCVAYGSNFVGGVTPGKGGTQFLDLPIFDSVLEA
CCCCCCCCCCEEECCCCCCCCCCCHHHEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHH
KQATGCRASMIFVPPPFAAEAIFEAEDAGIELIVCITEGIPVQDMLAVNSLMEKSSCRLV
HHCCCCEEEEEEECCCCHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCEEE
GPNCPGVIKPGACKIGIMPGYIHLPGNVGVISRSGTLTYEAVWQLTQRKIGQSVCIGIGG
CCCCCCCCCCCCEEEEECCCEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECC
DPLNGTSFIDVLQELEKDEQTEAILMIGEIGGSAEEDAADWISQHCSKPVIAFIAGATAP
CCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCC
KGKRMGHAGAIISGNSGDAFSKQRALREAGVVVVESPALIGEAVASVLNSH
CCCCCCCCCEEEECCCCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]