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The map label for this gene is sucC

Identifier: 15834828

GI number: 15834828

Start: 243912

End: 245072

Strand: Direct

Name: sucC

Synonym: TC0208

Alternate gene names: 15834828

Gene position: 243912-245072 (Clockwise)

Preceding gene: 15834826

Following gene: 15834829

Centisome position: 22.73

GC content: 40.4

Gene sequence:

>1161_bases
ATGCATCTTCATGAGTATCAAGCTAAGGACCTTTTAACCTCTTATCAACTTCCTATTCCTCCTTATCATGTAGCAACTTC
CCTATCTGAAGCTGAAGTCGCAATTCAAGCTGAGCAATGGAGAAGCGGAGTTGTTAAAGCTCAGGTTCATGCTGGAGGGA
GAGGAAAAAATGGAGGAGTTATTGTTGCGCGTTCTCCGGAGGACTTGTTAGCAGCAACTGATCGGCTTCTGCATATGCAA
TTTTCTAGTAATCAGACTGCTGGATTGTCCCTGCCAGTTAATAAAGTTTTGATTTCTCCTCTAGTAGAGATTGCTTTGGA
GTATTACATTGCTATTGTGATTGATAGAAAGCATCGTTGCCCAGTGATTATGCTTTCTAAATCAGGGGGCATTGATATCG
AAGAGATTGCAGAAAAACAACCAGATCTGTTGTTAAAAATAGCTCTTCCTTCTTCAGGGAAAATTTACGCGTATCAGTTG
CGCCACATTGCTAAATTTATGGAATGGGATAAACTCGTTGCTGATCGGGGGAACCACATCATCCGTAAGTTATTACAATG
TTTTTATGATAATGATGCTTCTTTATTGGAAATCAATCCTTTAGTGCTTACTAAAGATGGGGATCTGATTATTTTAGATG
CTAAAATAACGATTGATGATAACGCTCTCTATCGTCATCCACAGTTGGCCGATTGGTATGATCCTTCTCAAGAAAACATC
CGAGATGTATTGGCTAAGCAGCTGGGACTCTCTTATATTGCTTTAGATGGAACCATTGGGTGTTTAGTAAACGGAGCTGG
GTTAGCTATGAGTACTTTAGATATTCTTAAGCTATATGGTGGCTCAGCGGCGAATTTCTTAGATGTTGGAGGAAGCGCTT
CGGAAAAGCAAATTCAAGAAGCGATTTCTTTAGTTTTATCAGATAAAAATGTTCGCGTGTTGTTCATTCATATTTTTGGA
GGCATCATGGATTGTGCTGTTGTTGCTTCCGGGCTAGTATCAGCTATGCAGGGACAACAAGGAAGCATTCCTACGGTGAT
TCGTTTAGAAGGAACGAATGTAGATAAGGGAAAAGAAATCATTCTTAGATCAGGAATTCCTTGTGAATTTGTTGCCTCTA
TGAGTGAGGGGGCTGAGCTCGCAGTGAAATTAAGTCGTTAG

Upstream 100 bases:

>100_bases
AGCGAAGTTTGTTCCCGAAAAACTTGAACACAGACAGGGTAAAGTTGATTGAAGTAAAAAGGATAATAAAAGATAAGGAG
GAAAAATTAAAGGGTTATTT

Downstream 100 bases:

>100_bases
CCTGGGGAGAGACTGTGTTAGAATTATTAAACAAAGATCTGCCGATTATCACGCAGGGTATTACGGGGAAAGCAGGATCT
TTTCATACCACTCAATGTGT

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MHLHEYQAKDLLTSYQLPIPPYHVATSLSEAEVAIQAEQWRSGVVKAQVHAGGRGKNGGVIVARSPEDLLAATDRLLHMQ
FSSNQTAGLSLPVNKVLISPLVEIALEYYIAIVIDRKHRCPVIMLSKSGGIDIEEIAEKQPDLLLKIALPSSGKIYAYQL
RHIAKFMEWDKLVADRGNHIIRKLLQCFYDNDASLLEINPLVLTKDGDLIILDAKITIDDNALYRHPQLADWYDPSQENI
RDVLAKQLGLSYIALDGTIGCLVNGAGLAMSTLDILKLYGGSAANFLDVGGSASEKQIQEAISLVLSDKNVRVLFIHIFG
GIMDCAVVASGLVSAMQGQQGSIPTVIRLEGTNVDKGKEIILRSGIPCEFVASMSEGAELAVKLSR

Sequences:

>Translated_386_residues
MHLHEYQAKDLLTSYQLPIPPYHVATSLSEAEVAIQAEQWRSGVVKAQVHAGGRGKNGGVIVARSPEDLLAATDRLLHMQ
FSSNQTAGLSLPVNKVLISPLVEIALEYYIAIVIDRKHRCPVIMLSKSGGIDIEEIAEKQPDLLLKIALPSSGKIYAYQL
RHIAKFMEWDKLVADRGNHIIRKLLQCFYDNDASLLEINPLVLTKDGDLIILDAKITIDDNALYRHPQLADWYDPSQENI
RDVLAKQLGLSYIALDGTIGCLVNGAGLAMSTLDILKLYGGSAANFLDVGGSASEKQIQEAISLVLSDKNVRVLFIHIFG
GIMDCAVVASGLVSAMQGQQGSIPTVIRLEGTNVDKGKEIILRSGIPCEFVASMSEGAELAVKLSR
>Mature_386_residues
MHLHEYQAKDLLTSYQLPIPPYHVATSLSEAEVAIQAEQWRSGVVKAQVHAGGRGKNGGVIVARSPEDLLAATDRLLHMQ
FSSNQTAGLSLPVNKVLISPLVEIALEYYIAIVIDRKHRCPVIMLSKSGGIDIEEIAEKQPDLLLKIALPSSGKIYAYQL
RHIAKFMEWDKLVADRGNHIIRKLLQCFYDNDASLLEINPLVLTKDGDLIILDAKITIDDNALYRHPQLADWYDPSQENI
RDVLAKQLGLSYIALDGTIGCLVNGAGLAMSTLDILKLYGGSAANFLDVGGSASEKQIQEAISLVLSDKNVRVLFIHIFG
GIMDCAVVASGLVSAMQGQQGSIPTVIRLEGTNVDKGKEIILRSGIPCEFVASMSEGAELAVKLSR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI11321583, Length=392, Percent_Identity=39.5408163265306, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI157779135, Length=374, Percent_Identity=36.096256684492, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI294862256, Length=363, Percent_Identity=35.8126721763085, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI1786948, Length=386, Percent_Identity=44.0414507772021, Blast_Score=306, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17539378, Length=396, Percent_Identity=38.3838383838384, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17567829, Length=400, Percent_Identity=38.25, Blast_Score=271, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6321683, Length=396, Percent_Identity=36.1111111111111, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI21356231, Length=391, Percent_Identity=39.1304347826087, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI161078106, Length=393, Percent_Identity=36.3867684478371, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24645208, Length=393, Percent_Identity=36.3867684478371, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI281361397, Length=394, Percent_Identity=36.5482233502538, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI281361395, Length=394, Percent_Identity=36.5482233502538, Blast_Score=248, Evalue=4e-66,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SUCC_CHLMU (Q9PL99)

Other databases:

- EMBL:   AE002160
- PIR:   G81729
- RefSeq:   NP_296587.1
- ProteinModelPortal:   Q9PL99
- SMR:   Q9PL99
- GeneID:   1246334
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0208
- TIGR:   TC_0208
- HOGENOM:   HBG315432
- OMA:   NPLIVMK
- PhylomeDB:   Q9PL99
- ProtClustDB:   PRK00696
- BioCyc:   CMUR243161:TC_0208-MONOMER
- BRENDA:   6.2.1.5
- HAMAP:   MF_00558
- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.261
- PANTHER:   PTHR11815
- TIGRFAMs:   TIGR01016

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 42018; Mature: 42018

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS50975 ATP_GRASP; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLHEYQAKDLLTSYQLPIPPYHVATSLSEAEVAIQAEQWRSGVVKAQVHAGGRGKNGGV
CCCCHHHHHHHHHHCCCCCCCHHHHCCCCHHHEEEEHHHHHCCCEEEEEECCCCCCCCCE
IVARSPEDLLAATDRLLHMQFSSNQTAGLSLPVNKVLISPLVEIALEYYIAIVIDRKHRC
EEEECCHHHHHHHHHHEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHEEEEEEECCCCC
PVIMLSKSGGIDIEEIAEKQPDLLLKIALPSSGKIYAYQLRHIAKFMEWDKLVADRGNHI
CEEEEECCCCCCHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHCCCHH
IRKLLQCFYDNDASLLEINPLVLTKDGDLIILDAKITIDDNALYRHPQLADWYDPSQENI
HHHHHHHHHCCCCCEEEECCEEEECCCCEEEEEEEEEECCCCEECCCCCCCCCCCCHHHH
RDVLAKQLGLSYIALDGTIGCLVNGAGLAMSTLDILKLYGGSAANFLDVGGSASEKQIQE
HHHHHHHHCCEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHH
AISLVLSDKNVRVLFIHIFGGIMDCAVVASGLVSAMQGQQGSIPTVIRLEGTNVDKGKEI
HHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEE
ILRSGIPCEFVASMSEGAELAVKLSR
EEECCCCHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MHLHEYQAKDLLTSYQLPIPPYHVATSLSEAEVAIQAEQWRSGVVKAQVHAGGRGKNGGV
CCCCHHHHHHHHHHCCCCCCCHHHHCCCCHHHEEEEHHHHHCCCEEEEEECCCCCCCCCE
IVARSPEDLLAATDRLLHMQFSSNQTAGLSLPVNKVLISPLVEIALEYYIAIVIDRKHRC
EEEECCHHHHHHHHHHEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHEEEEEEECCCCC
PVIMLSKSGGIDIEEIAEKQPDLLLKIALPSSGKIYAYQLRHIAKFMEWDKLVADRGNHI
CEEEEECCCCCCHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHCCCHH
IRKLLQCFYDNDASLLEINPLVLTKDGDLIILDAKITIDDNALYRHPQLADWYDPSQENI
HHHHHHHHHCCCCCEEEECCEEEECCCCEEEEEEEEEECCCCEECCCCCCCCCCCCHHHH
RDVLAKQLGLSYIALDGTIGCLVNGAGLAMSTLDILKLYGGSAANFLDVGGSASEKQIQE
HHHHHHHHCCEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHH
AISLVLSDKNVRVLFIHIFGGIMDCAVVASGLVSAMQGQQGSIPTVIRLEGTNVDKGKEI
HHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEE
ILRSGIPCEFVASMSEGAELAVKLSR
EEECCCCHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935