Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15834824

GI number: 15834824

Start: 239589

End: 240785

Strand: Direct

Name: Not Available

Synonym: TC0204

Alternate gene names: 15834824

Gene position: 239589-240785 (Clockwise)

Preceding gene: 15834823

Following gene: 15834825

Centisome position: 22.33

GC content: 39.35

Gene sequence:

>1197_bases
ATGATAAACAAAATGTTGGGTGGAGCCTTGATTGTCGCAGGGACAACCATTGGCGCCGGAGTGTTAGCTGTTCCTATTGC
CACTTCAGAGGGAGGATTTCTGCCTACAACATTACTTTATGTTGTTTCTTGGTTAATAGCAGTAGCTTCTGGATACTGTT
TTTTAGAAGTGTTGACCTGGCTACATGCAAGAAAGAACGTCAATATGGTTTCCATGGCAGAGTGTACTTTAGGGTACAAG
AGCAAGGTAATCATGTGGTTGGTTTATCTGCTTTTATTCTACTCCCTTCTAGTTGCTTACTTTTGTGATGGTGGAAATAT
TCTTATGCGTGTCATGGGATGCCGTGATTGGGATACGCCTTGGATCAGACACGCTATGCCTATAGTATTTTTCGCGCTGT
TTTCTCCTCTTTTAATGGCAAAAACTTCTATTGTTGATCAGTGTAATAGAGTTTTTGTTTTGGGATTAGGGATATCGTTT
GCTATGTTTTGCTATTTCGGATTCCCTTTGATGAAAACAGAACTATTAGTGAGATCTTCATGGGGAGGAACCTTAAAAGG
ATTCCCCATTTTGTTTTTAGCTTTTGGATTTCAAAACGTGGTTCCCACTCTATACCATTACATGGACAAAAACGTAAGAG
ATGTAAAGAAGGCTATTGTAATTGGAAGTTTCATTCCTCTAGTTTTGTATGTAATTTGGGAAGCCATTGTATTAGGAGCT
GTTCCAGTTTCATTTTTGGAACAAGCTAAGATGGAAGGATGGACTGCGATTGGGGCTTTGCAAGGAGCTTTGAAGTGTTC
TGCTTTCTATATTGCCGGGGAATTTTTTGGATTTTTTGCTTTAATTTCCTCGTTTATTGGTGTAGCTCTTGGGCTAAAAG
ATTTCTTTATAGATGCTTTTCAATGGGATGAGAAGAAACGTAAATTAGAAATCTTTTTATTAGTTTTTGTATTTCCTTTG
GTGTGGGCCGTTTTCTATCCAGGCATTGTTTTGAAATGTTTGGAGTGTACCGGAGCTTTAGGAGAGACCATCGTATTGGG
AGTCTTCCCTGTACTTATGGTCTGGAAAGGGCGCTATGGGAAGAAACGATACTACGGTCAAAGAATTCTCCCTGGAGGTA
AGGGAGCTTTATTAGTTATGTCAGGACTGGTACTTGTGAACTTAGTCTTGATCGTACAGAAATTTCTTGGATATTAA

Upstream 100 bases:

>100_bases
TTACAATTTTTTTCTCTCTTGATGAATAGCATAACCATCTGTATGTTAGAGAGAATCGAGAGATGTTAAATGGATTCATC
TCTTTAAGAAGGGTATTCTC

Downstream 100 bases:

>100_bases
TTTTTTAAATCAATAACTTAGGCTCGCATTAAACAGTTGTTGGTGCGAGCATTTTTGTGTTTTGAAAATGGATGCAGATT
ATGAAACAAGAGGTATTCTA

Product: Mtr/TnaB/TyrO permease family protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MINKMLGGALIVAGTTIGAGVLAVPIATSEGGFLPTTLLYVVSWLIAVASGYCFLEVLTWLHARKNVNMVSMAECTLGYK
SKVIMWLVYLLLFYSLLVAYFCDGGNILMRVMGCRDWDTPWIRHAMPIVFFALFSPLLMAKTSIVDQCNRVFVLGLGISF
AMFCYFGFPLMKTELLVRSSWGGTLKGFPILFLAFGFQNVVPTLYHYMDKNVRDVKKAIVIGSFIPLVLYVIWEAIVLGA
VPVSFLEQAKMEGWTAIGALQGALKCSAFYIAGEFFGFFALISSFIGVALGLKDFFIDAFQWDEKKRKLEIFLLVFVFPL
VWAVFYPGIVLKCLECTGALGETIVLGVFPVLMVWKGRYGKKRYYGQRILPGGKGALLVMSGLVLVNLVLIVQKFLGY

Sequences:

>Translated_398_residues
MINKMLGGALIVAGTTIGAGVLAVPIATSEGGFLPTTLLYVVSWLIAVASGYCFLEVLTWLHARKNVNMVSMAECTLGYK
SKVIMWLVYLLLFYSLLVAYFCDGGNILMRVMGCRDWDTPWIRHAMPIVFFALFSPLLMAKTSIVDQCNRVFVLGLGISF
AMFCYFGFPLMKTELLVRSSWGGTLKGFPILFLAFGFQNVVPTLYHYMDKNVRDVKKAIVIGSFIPLVLYVIWEAIVLGA
VPVSFLEQAKMEGWTAIGALQGALKCSAFYIAGEFFGFFALISSFIGVALGLKDFFIDAFQWDEKKRKLEIFLLVFVFPL
VWAVFYPGIVLKCLECTGALGETIVLGVFPVLMVWKGRYGKKRYYGQRILPGGKGALLVMSGLVLVNLVLIVQKFLGY
>Mature_398_residues
MINKMLGGALIVAGTTIGAGVLAVPIATSEGGFLPTTLLYVVSWLIAVASGYCFLEVLTWLHARKNVNMVSMAECTLGYK
SKVIMWLVYLLLFYSLLVAYFCDGGNILMRVMGCRDWDTPWIRHAMPIVFFALFSPLLMAKTSIVDQCNRVFVLGLGISF
AMFCYFGFPLMKTELLVRSSWGGTLKGFPILFLAFGFQNVVPTLYHYMDKNVRDVKKAIVIGSFIPLVLYVIWEAIVLGA
VPVSFLEQAKMEGWTAIGALQGALKCSAFYIAGEFFGFFALISSFIGVALGLKDFFIDAFQWDEKKRKLEIFLLVFVFPL
VWAVFYPGIVLKCLECTGALGETIVLGVFPVLMVWKGRYGKKRYYGQRILPGGKGALLVMSGLVLVNLVLIVQKFLGY

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=389, Percent_Identity=30.3341902313625, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1789552, Length=354, Percent_Identity=25.7062146892655, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790145, Length=377, Percent_Identity=24.9336870026525, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44201; Mature: 44201

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINKMLGGALIVAGTTIGAGVLAVPIATSEGGFLPTTLLYVVSWLIAVASGYCFLEVLTW
CCCCHHCCEEEEECCHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
LHARKNVNMVSMAECTLGYKSKVIMWLVYLLLFYSLLVAYFCDGGNILMRVMGCRDWDTP
HHHHCCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCH
WIRHAMPIVFFALFSPLLMAKTSIVDQCNRVFVLGLGISFAMFCYFGFPLMKTELLVRSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHCC
WGGTLKGFPILFLAFGFQNVVPTLYHYMDKNVRDVKKAIVIGSFIPLVLYVIWEAIVLGA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPVSFLEQAKMEGWTAIGALQGALKCSAFYIAGEFFGFFALISSFIGVALGLKDFFIDAF
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QWDEKKRKLEIFLLVFVFPLVWAVFYPGIVLKCLECTGALGETIVLGVFPVLMVWKGRYG
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
KKRYYGQRILPGGKGALLVMSGLVLVNLVLIVQKFLGY
CHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MINKMLGGALIVAGTTIGAGVLAVPIATSEGGFLPTTLLYVVSWLIAVASGYCFLEVLTW
CCCCHHCCEEEEECCHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
LHARKNVNMVSMAECTLGYKSKVIMWLVYLLLFYSLLVAYFCDGGNILMRVMGCRDWDTP
HHHHCCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCH
WIRHAMPIVFFALFSPLLMAKTSIVDQCNRVFVLGLGISFAMFCYFGFPLMKTELLVRSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHCC
WGGTLKGFPILFLAFGFQNVVPTLYHYMDKNVRDVKKAIVIGSFIPLVLYVIWEAIVLGA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPVSFLEQAKMEGWTAIGALQGALKCSAFYIAGEFFGFFALISSFIGVALGLKDFFIDAF
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QWDEKKRKLEIFLLVFVFPLVWAVFYPGIVLKCLECTGALGETIVLGVFPVLMVWKGRYG
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
KKRYYGQRILPGGKGALLVMSGLVLVNLVLIVQKFLGY
CHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]