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The map label for this gene is glmS

Identifier: 15834823

GI number: 15834823

Start: 237665

End: 239485

Strand: Direct

Name: glmS

Synonym: TC0203

Alternate gene names: 15834823

Gene position: 237665-239485 (Clockwise)

Preceding gene: 15834822

Following gene: 15834824

Centisome position: 22.15

GC content: 41.57

Gene sequence:

>1821_bases
ATGTGTGGAATATTTGGATATTTAGGACAAAGAAATGCTGTGCCACTAGTTTTGGAAGGGTTATCTAAACTAGAGTATCG
TGGGTACGATTCTGCAGGAATAGCAGCTCTCACTAAAGACCATTTGTTTGTAGAAAAATCCGTAGGGCCTGTAAGTCAGC
TATGCTCGAAGGTTTCTTCTGATATGCATTCTCAGGTAGCGATAGGTCACACTCGGTGGGCTACACATGGGGAGCCTTCA
AGGTTCAATGCACATCCCCATGTGGATATGTATGAGAGTTGTGCTCTTGTTCATAATGGAATTATAGAGAACTTTCAAAC
GCTTAGAGAAGATTTGAGTAGTAAGGGCGTTGAGTTTTCATCGGATACGGACACAGAGGTTATTGTACAACTTTTTGCGA
GTCGATATAGAGAAACAGGAGATTTAGTTCAGAGTTTTTCATGGACTCTGAAACAGTTACAGGGAAGTTTCGCTTGTGCT
TTAGTGCACCAGGATCACCCTGAAATTTTACTATGCGCTACCTATGAAAGCCCGCTTATTTTAGGATTAGGAGAAGAAGA
GGTATTCATTTCTTCTGATGTCCATGCTTTTTTGAAGTATTCGTGCCAAATACAAACCTTAGCTTCTGGAGAGCTGGCAG
TTTTACGTATAGGACGGCCTGTTGAGATTTACAACTTTGAGTTGTCTCGTATTCAAAAAGAAGTGCGCTGTATAGACCAT
GCAGAAGGTTCTTTAGATAAACAAGGTTTTGATTATTACATGCTCAAAGAGATTTATGAGCAGCCAGAGGTGTTTGAACG
TATTTTGCATTTTGTGTGTGAAGAGAATGGATTTGCAGAATCTTTTTTAAAAGAATTTTCTTTTGAAGGTATCGAGAGTT
TGCATATCGTGGCTTGTGGGTCTTCTTATCATGCCGGTTGTTTAGCCAAGTATGTCATCGAGTCAATGGTCTCGATTCCC
GTGTATGTGGAGACCGCTTCTGAGTTTCGTTATCGTCAACCATACATAGCAAAACGTTCTTTAGCTATTTTGATTAGCCA
ATCGGGAGAGACTGCTGATACCTTGGCTGCTCTAAACGAGTTCCGTAAACTAGATGAAGTGCGTGTGTTGGGTATTTGTA
ATGTACGAGGGTCTGTGCTCGCTTCCCGAGTAGACCATTGCGTATTTATCGAAGCCGGTTTGGAAGTGGGGGTAGCTTCA
ACAAAGGCATTTACAGCGCAGTTATTAGTATTGATTCTTCTAGGTCTGAAATTAGCAAGTCAGCGTCAAGAGATTTCTAA
ACAAGATTTGATGCAAGCGGTACAGGGATTAAGAGAGCTGCCTCGGTTGACAAGACTTTTCTTGGATAGTTCTATTCATG
ATTGGCGATGTCGACAAAGTAAAGAAACGAGCTTTATTTTCTTAGGGCGCCGTTTTATGTACCCGATTTGTATGGAAGCG
GCTTTGAAATTAAAAGAAATCGCTTATGTGGAAGCTAATGCTTATCCCGCGGGAGAGATGAAACACGGGCCAATTGCTCT
TATTCAGGAAGGGACTCCTGTTATTGTATATTGCGGGGATCCCTTTGTATATACCAAAACTATTGGGGCAATTATGGAGG
TAAAGGCTAGAAAAGCCTATGTTATTGCTCTTGCTCGAGAATCGAACCAAGATATTGCAGCGGTTTCTGACGAACAAATT
TATATTCCCGATAGTCATGATCTTGCAGCCCCTATTTTATTTGCTATAGCGGGACAGATCATGGCGTATACGATGGCCTT
GCAAAAAGGCACTGAGGTGGATAGACCAAGGAATTTAGCTAAATCTGTGACTGTAGAGTGA

Upstream 100 bases:

>100_bases
GGACAAAGAAGCATCAGGTAGACTCTCTTGCTAAAACAATTGTGGATGTTGTAGAAGCAGAAATTGGAGGAGCAGAGATT
TCTGAATAGTAGGAATCGAT

Downstream 100 bases:

>100_bases
GATTTACAATTTTTTTCTCTCTTGATGAATAGCATAACCATCTGTATGTTAGAGAGAATCGAGAGATGTTAAATGGATTC
ATCTCTTTAAGAAGGGTATT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MCGIFGYLGQRNAVPLVLEGLSKLEYRGYDSAGIAALTKDHLFVEKSVGPVSQLCSKVSSDMHSQVAIGHTRWATHGEPS
RFNAHPHVDMYESCALVHNGIIENFQTLREDLSSKGVEFSSDTDTEVIVQLFASRYRETGDLVQSFSWTLKQLQGSFACA
LVHQDHPEILLCATYESPLILGLGEEEVFISSDVHAFLKYSCQIQTLASGELAVLRIGRPVEIYNFELSRIQKEVRCIDH
AEGSLDKQGFDYYMLKEIYEQPEVFERILHFVCEENGFAESFLKEFSFEGIESLHIVACGSSYHAGCLAKYVIESMVSIP
VYVETASEFRYRQPYIAKRSLAILISQSGETADTLAALNEFRKLDEVRVLGICNVRGSVLASRVDHCVFIEAGLEVGVAS
TKAFTAQLLVLILLGLKLASQRQEISKQDLMQAVQGLRELPRLTRLFLDSSIHDWRCRQSKETSFIFLGRRFMYPICMEA
ALKLKEIAYVEANAYPAGEMKHGPIALIQEGTPVIVYCGDPFVYTKTIGAIMEVKARKAYVIALARESNQDIAAVSDEQI
YIPDSHDLAAPILFAIAGQIMAYTMALQKGTEVDRPRNLAKSVTVE

Sequences:

>Translated_606_residues
MCGIFGYLGQRNAVPLVLEGLSKLEYRGYDSAGIAALTKDHLFVEKSVGPVSQLCSKVSSDMHSQVAIGHTRWATHGEPS
RFNAHPHVDMYESCALVHNGIIENFQTLREDLSSKGVEFSSDTDTEVIVQLFASRYRETGDLVQSFSWTLKQLQGSFACA
LVHQDHPEILLCATYESPLILGLGEEEVFISSDVHAFLKYSCQIQTLASGELAVLRIGRPVEIYNFELSRIQKEVRCIDH
AEGSLDKQGFDYYMLKEIYEQPEVFERILHFVCEENGFAESFLKEFSFEGIESLHIVACGSSYHAGCLAKYVIESMVSIP
VYVETASEFRYRQPYIAKRSLAILISQSGETADTLAALNEFRKLDEVRVLGICNVRGSVLASRVDHCVFIEAGLEVGVAS
TKAFTAQLLVLILLGLKLASQRQEISKQDLMQAVQGLRELPRLTRLFLDSSIHDWRCRQSKETSFIFLGRRFMYPICMEA
ALKLKEIAYVEANAYPAGEMKHGPIALIQEGTPVIVYCGDPFVYTKTIGAIMEVKARKAYVIALARESNQDIAAVSDEQI
YIPDSHDLAAPILFAIAGQIMAYTMALQKGTEVDRPRNLAKSVTVE
>Mature_606_residues
MCGIFGYLGQRNAVPLVLEGLSKLEYRGYDSAGIAALTKDHLFVEKSVGPVSQLCSKVSSDMHSQVAIGHTRWATHGEPS
RFNAHPHVDMYESCALVHNGIIENFQTLREDLSSKGVEFSSDTDTEVIVQLFASRYRETGDLVQSFSWTLKQLQGSFACA
LVHQDHPEILLCATYESPLILGLGEEEVFISSDVHAFLKYSCQIQTLASGELAVLRIGRPVEIYNFELSRIQKEVRCIDH
AEGSLDKQGFDYYMLKEIYEQPEVFERILHFVCEENGFAESFLKEFSFEGIESLHIVACGSSYHAGCLAKYVIESMVSIP
VYVETASEFRYRQPYIAKRSLAILISQSGETADTLAALNEFRKLDEVRVLGICNVRGSVLASRVDHCVFIEAGLEVGVAS
TKAFTAQLLVLILLGLKLASQRQEISKQDLMQAVQGLRELPRLTRLFLDSSIHDWRCRQSKETSFIFLGRRFMYPICMEA
ALKLKEIAYVEANAYPAGEMKHGPIALIQEGTPVIVYCGDPFVYTKTIGAIMEVKARKAYVIALARESNQDIAAVSDEQI
YIPDSHDLAAPILFAIAGQIMAYTMALQKGTEVDRPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=691, Percent_Identity=34.2981186685962, Blast_Score=333, Evalue=4e-91,
Organism=Homo sapiens, GI205277386, Length=702, Percent_Identity=32.3361823361823, Blast_Score=315, Evalue=8e-86,
Organism=Homo sapiens, GI29570798, Length=183, Percent_Identity=29.5081967213115, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1790167, Length=621, Percent_Identity=41.8679549114332, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1788651, Length=194, Percent_Identity=27.8350515463918, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17532899, Length=510, Percent_Identity=33.921568627451, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17532897, Length=439, Percent_Identity=35.9908883826879, Blast_Score=226, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17539970, Length=440, Percent_Identity=35.6818181818182, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17554892, Length=218, Percent_Identity=29.8165137614679, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322745, Length=445, Percent_Identity=35.7303370786517, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323731, Length=448, Percent_Identity=27.6785714285714, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=34.7826086956522, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21357745, Length=689, Percent_Identity=32.510885341074, Blast_Score=325, Evalue=6e-89,
Organism=Drosophila melanogaster, GI28573187, Length=142, Percent_Identity=32.3943661971831, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_CHLMU (Q9PLA4)

Other databases:

- EMBL:   AE002160
- PIR:   B81729
- RefSeq:   NP_296582.1
- ProteinModelPortal:   Q9PLA4
- SMR:   Q9PLA4
- GeneID:   1246329
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0203
- TIGR:   TC_0203
- HOGENOM:   HBG645312
- OMA:   FGKNAKS
- ProtClustDB:   PRK00331
- BioCyc:   CMUR243161:TC_0203-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67569; Mature: 67569

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 601-601

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIFGYLGQRNAVPLVLEGLSKLEYRGYDSAGIAALTKDHLFVEKSVGPVSQLCSKVSS
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHEECCCEEEECCCCHHHHHHHHHHH
DMHSQVAIGHTRWATHGEPSRFNAHPHVDMYESCALVHNGIIENFQTLREDLSSKGVEFS
HHHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SDTDTEVIVQLFASRYRETGDLVQSFSWTLKQLQGSFACALVHQDHPEILLCATYESPLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEE
LGLGEEEVFISSDVHAFLKYSCQIQTLASGELAVLRIGRPVEIYNFELSRIQKEVRCIDH
EECCCCCEEEECCHHHHHHHCEEEEEECCCCEEEEEECCCEEEEECHHHHHHHHHHHHHC
AEGSLDKQGFDYYMLKEIYEQPEVFERILHFVCEENGFAESFLKEFSFEGIESLHIVACG
CCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEEC
SSYHAGCLAKYVIESMVSIPVYVETASEFRYRQPYIAKRSLAILISQSGETADTLAALNE
CCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCHHCCCEEEEEECCCCHHHHHHHHHH
FRKLDEVRVLGICNVRGSVLASRVDHCVFIEAGLEVGVASTKAFTAQLLVLILLGLKLAS
HHHHHHEEEEEEECCHHHHHHHHCCCEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHH
QRQEISKQDLMQAVQGLRELPRLTRLFLDSSIHDWRCRQSKETSFIFLGRRFMYPICMEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEECHHHHHHHHHHH
ALKLKEIAYVEANAYPAGEMKHGPIALIQEGTPVIVYCGDPFVYTKTIGAIMEVKARKAY
HHHHHHHEEEECCCCCCCCCCCCCEEEEECCCEEEEECCCCEEEHHHHHHHHHHHCCEEE
VIALARESNQDIAAVSDEQIYIPDSHDLAAPILFAIAGQIMAYTMALQKGTEVDRPRNLA
EEEEEECCCCCEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
KSVTVE
HHCCCC
>Mature Secondary Structure
MCGIFGYLGQRNAVPLVLEGLSKLEYRGYDSAGIAALTKDHLFVEKSVGPVSQLCSKVSS
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHEECCCEEEECCCCHHHHHHHHHHH
DMHSQVAIGHTRWATHGEPSRFNAHPHVDMYESCALVHNGIIENFQTLREDLSSKGVEFS
HHHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SDTDTEVIVQLFASRYRETGDLVQSFSWTLKQLQGSFACALVHQDHPEILLCATYESPLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEE
LGLGEEEVFISSDVHAFLKYSCQIQTLASGELAVLRIGRPVEIYNFELSRIQKEVRCIDH
EECCCCCEEEECCHHHHHHHCEEEEEECCCCEEEEEECCCEEEEECHHHHHHHHHHHHHC
AEGSLDKQGFDYYMLKEIYEQPEVFERILHFVCEENGFAESFLKEFSFEGIESLHIVACG
CCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEEC
SSYHAGCLAKYVIESMVSIPVYVETASEFRYRQPYIAKRSLAILISQSGETADTLAALNE
CCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCHHCCCEEEEEECCCCHHHHHHHHHH
FRKLDEVRVLGICNVRGSVLASRVDHCVFIEAGLEVGVASTKAFTAQLLVLILLGLKLAS
HHHHHHEEEEEEECCHHHHHHHHCCCEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHH
QRQEISKQDLMQAVQGLRELPRLTRLFLDSSIHDWRCRQSKETSFIFLGRRFMYPICMEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEECHHHHHHHHHHH
ALKLKEIAYVEANAYPAGEMKHGPIALIQEGTPVIVYCGDPFVYTKTIGAIMEVKARKAY
HHHHHHHEEEECCCCCCCCCCCCCEEEEECCCEEEEECCCCEEEHHHHHHHHHHHCCEEE
VIALARESNQDIAAVSDEQIYIPDSHDLAAPILFAIAGQIMAYTMALQKGTEVDRPRNLA
EEEEEECCCCCEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
KSVTVE
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935