Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15834778

GI number: 15834778

Start: 190918

End: 192045

Strand: Direct

Name: Not Available

Synonym: TC0158

Alternate gene names: 15834778

Gene position: 190918-192045 (Clockwise)

Preceding gene: 15834777

Following gene: 15834781

Centisome position: 17.79

GC content: 41.58

Gene sequence:

>1128_bases
TTGAAGGGGTCGCGTTCTATTGATTTTATTACCAATGATTTCCTTGGTTTTTCTCGTTTAGAGGGTTTGTCGGATGCTGT
TGAGGCTCGTTATCAACGTTATTGTATTAGCGAGCCTTATGCGCGTTTGGGTTACGGAGGATCTCGTTCTATCTTAGGTC
CTTCCGAATTGTTAAATGAATTAGAGCAGGGAATAGCACATTTTCATGGTGTTGCAGAAGCTCTTGTTTTGCCAAGTGGT
TTTGTTGCAAATACAACGGTTTGTGCACACCTGTCTTCTGCAGCCGATTATGTTTTGTGGGATGAACAGGCGCATATTTC
TGTTTCCTATAACATGGCCCTTTTTATGCCGGAGAAACAAAAGAGTTTCCGTCATAATGATCTGAATCATTTAGAATCTT
TACTCGCTTCTTGTCAGAAGCAAGGTTTCAAGCGAGTATTTATTCTTGTCTGTTCCGTTTATTCCTTTAAGGGATCCTTT
GCTCCTTTGAAGCAAATAGTTGCTCTGGCGCAAAGATATCATGCGCAGTTGATAGTCGATGAAGCCCATGCTGTGGGATT
ATTTGGTGAGTCTGGAAGGGGATTTTGTTCCTCAATAGGATATGAAAATGTTTATGCAGTGCTTGTCACTTTTGGTAAGG
CTTTAGGATCTGTAGGTGCAGCTCTTTTATCTTCTTATGATAGGAAGCAGGATTTCATCAAAGAGCCTATGGCGAGTCTT
TCTACAGGAATGCCTCCGCATTCATTGATTTCTATACAAGTTGCTTATGAATTTCTATCAAAAGAAGGAGAATTTGCACG
AACTAGATTGCGACAGATTCGAGAGTATTTTGCTCAAAAGGTCTCCTCAGCAGCCCCAGGGTTTGTGCAGCCGATTTCCT
CTCCAAGTGTTCCTTCGCAGGTTTTACATCAGCAGCTAACTGAAGCTGGGGTTCGAGTTGGGATTACGCGATTCCCTGCA
AAGGGATCTTTGCGAGCCAATTTGCATGCTTTTAATACTAAAGAGGAAGTGGATATTTTGGTTTCGATACTTTCGCAAGT
ATCAGATCAAAAGAATGTAGTAATGGGATCTATGTCCACGATGCATCGTACTTTAGAAGAAAGTTTAGCAGCTGAAAATG
CATCCTGA

Upstream 100 bases:

>100_bases
TGGGAAACCGGATTACTGCTCACTAAATGCTTTAGCAAAACGGTTATTTGGCGAATAAGGACTTCTTTTTAGATTGTTAT
AGTTATGAGGAAAATGAGTT

Downstream 100 bases:

>100_bases
AGCTGTTTATTTACAGTGAGAATGTTGCGAGTTTTGATCAAAAATTGATAGTGAAAAAGGTCTTTTACTTTGAAGTGCCC
ACAGGGGGATATGTCCATAA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MKGSRSIDFITNDFLGFSRLEGLSDAVEARYQRYCISEPYARLGYGGSRSILGPSELLNELEQGIAHFHGVAEALVLPSG
FVANTTVCAHLSSAADYVLWDEQAHISVSYNMALFMPEKQKSFRHNDLNHLESLLASCQKQGFKRVFILVCSVYSFKGSF
APLKQIVALAQRYHAQLIVDEAHAVGLFGESGRGFCSSIGYENVYAVLVTFGKALGSVGAALLSSYDRKQDFIKEPMASL
STGMPPHSLISIQVAYEFLSKEGEFARTRLRQIREYFAQKVSSAAPGFVQPISSPSVPSQVLHQQLTEAGVRVGITRFPA
KGSLRANLHAFNTKEEVDILVSILSQVSDQKNVVMGSMSTMHRTLEESLAAENAS

Sequences:

>Translated_375_residues
MKGSRSIDFITNDFLGFSRLEGLSDAVEARYQRYCISEPYARLGYGGSRSILGPSELLNELEQGIAHFHGVAEALVLPSG
FVANTTVCAHLSSAADYVLWDEQAHISVSYNMALFMPEKQKSFRHNDLNHLESLLASCQKQGFKRVFILVCSVYSFKGSF
APLKQIVALAQRYHAQLIVDEAHAVGLFGESGRGFCSSIGYENVYAVLVTFGKALGSVGAALLSSYDRKQDFIKEPMASL
STGMPPHSLISIQVAYEFLSKEGEFARTRLRQIREYFAQKVSSAAPGFVQPISSPSVPSQVLHQQLTEAGVRVGITRFPA
KGSLRANLHAFNTKEEVDILVSILSQVSDQKNVVMGSMSTMHRTLEESLAAENAS
>Mature_375_residues
MKGSRSIDFITNDFLGFSRLEGLSDAVEARYQRYCISEPYARLGYGGSRSILGPSELLNELEQGIAHFHGVAEALVLPSG
FVANTTVCAHLSSAADYVLWDEQAHISVSYNMALFMPEKQKSFRHNDLNHLESLLASCQKQGFKRVFILVCSVYSFKGSF
APLKQIVALAQRYHAQLIVDEAHAVGLFGESGRGFCSSIGYENVYAVLVTFGKALGSVGAALLSSYDRKQDFIKEPMASL
STGMPPHSLISIQVAYEFLSKEGEFARTRLRQIREYFAQKVSSAAPGFVQPISSPSVPSQVLHQQLTEAGVRVGITRFPA
KGSLRANLHAFNTKEEVDILVSILSQVSDQKNVVMGSMSTMHRTLEESLAAENAS

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4758668, Length=373, Percent_Identity=26.0053619302949, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7657118, Length=359, Percent_Identity=26.7409470752089, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI83977442, Length=251, Percent_Identity=31.4741035856574, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI284448556, Length=359, Percent_Identity=26.7409470752089, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI83977444, Length=305, Percent_Identity=29.5081967213115, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI83977440, Length=305, Percent_Identity=29.5081967213115, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI119220554, Length=339, Percent_Identity=25.9587020648968, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4502025, Length=220, Percent_Identity=31.3636363636364, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI40316939, Length=220, Percent_Identity=31.3636363636364, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI5454084, Length=230, Percent_Identity=26.0869565217391, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1790046, Length=368, Percent_Identity=25.8152173913043, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786993, Length=299, Percent_Identity=30.7692307692308, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71994529, Length=365, Percent_Identity=26.027397260274, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17560914, Length=328, Percent_Identity=26.8292682926829, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17560912, Length=328, Percent_Identity=26.8292682926829, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI32566772, Length=383, Percent_Identity=25.5874673629243, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71982625, Length=230, Percent_Identity=23.9130434782609, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71982617, Length=230, Percent_Identity=23.9130434782609, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320438, Length=267, Percent_Identity=32.5842696629214, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320267, Length=372, Percent_Identity=25, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323954, Length=322, Percent_Identity=25.776397515528, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136286, Length=382, Percent_Identity=29.0575916230367, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24662918, Length=370, Percent_Identity=27.2972972972973, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17137420, Length=366, Percent_Identity=28.9617486338798, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24653280, Length=240, Percent_Identity=23.75, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24653276, Length=240, Percent_Identity=23.75, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24653278, Length=240, Percent_Identity=23.75, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 41089; Mature: 41089

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGSRSIDFITNDFLGFSRLEGLSDAVEARYQRYCISEPYARLGYGGSRSILGPSELLNE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHH
LEQGIAHFHGVAEALVLPSGFVANTTVCAHLSSAADYVLWDEQAHISVSYNMALFMPEKQ
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEECCCCEEEEEEEEEEEECCHH
KSFRHNDLNHLESLLASCQKQGFKRVFILVCSVYSFKGSFAPLKQIVALAQRYHAQLIVD
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEE
EAHAVGLFGESGRGFCSSIGYENVYAVLVTFGKALGSVGAALLSSYDRKQDFIKEPMASL
CHHHEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STGMPPHSLISIQVAYEFLSKEGEFARTRLRQIREYFAQKVSSAAPGFVQPISSPSVPSQ
HCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
VLHQQLTEAGVRVGITRFPAKGSLRANLHAFNTKEEVDILVSILSQVSDQKNVVMGSMST
HHHHHHHHHHHHCCCEECCCCCCCEECEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
MHRTLEESLAAENAS
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MKGSRSIDFITNDFLGFSRLEGLSDAVEARYQRYCISEPYARLGYGGSRSILGPSELLNE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHH
LEQGIAHFHGVAEALVLPSGFVANTTVCAHLSSAADYVLWDEQAHISVSYNMALFMPEKQ
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEECCCCEEEEEEEEEEEECCHH
KSFRHNDLNHLESLLASCQKQGFKRVFILVCSVYSFKGSFAPLKQIVALAQRYHAQLIVD
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEE
EAHAVGLFGESGRGFCSSIGYENVYAVLVTFGKALGSVGAALLSSYDRKQDFIKEPMASL
CHHHEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STGMPPHSLISIQVAYEFLSKEGEFARTRLRQIREYFAQKVSSAAPGFVQPISSPSVPSQ
HCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
VLHQQLTEAGVRVGITRFPAKGSLRANLHAFNTKEEVDILVSILSQVSDQKNVVMGSMST
HHHHHHHHHHHHCCCEECCCCCCCEECEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
MHRTLEESLAAENAS
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA