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Identifier: 15834777

GI number: 15834777

Start: 189262

End: 190875

Strand: Direct

Name: Not Available

Synonym: TC0157

Alternate gene names: 15834777

Gene position: 189262-190875 (Clockwise)

Preceding gene: 15834776

Following gene: 15834778

Centisome position: 17.64

GC content: 41.08

Gene sequence:

>1614_bases
ATGCGAGATAATAGGAATACAGCTAAACATAAACGCGGGAAATTGCGATCAGAGAAAACAGTTTTGTGTAGTTTTTTGAA
GCTTTGTGCGGAGATGACTACAGCAACAGTTTTCTGGGATGAGCAACTTGGTAAGCTCTCCTATAATCAGGTGTATAAGG
CAGTTTGTGCCTTAGCTACGCGTTTGGCTAAATACCCTGATGAACATATCGGAATTATGATGCCAGCATCGTCCGGGGCT
TATATTGCTTACTTTGCGACGCTCCTTTCAGGGAAGATTCCCGTTATGATTAATTGGAGTCAAGGATTACGGGAAGTAAC
GGCATGTGCAAATCTTGTTGGGGTAAAGCATGTAATTACTGCGAAGCCTCTTATGCAAAAGTTAGCGCAAACTCATGGAG
AGAATGCAGAGTATCCTTTCTCATTGATTTTTCTAGAAGAGATCCGTAAGGAATTGACTTTTCTAGATAAGTGTCGAGTT
GGGATCTGTATGTCCATGCCTTTTGAATGGATGATGCGATGGTTTGGATCCTTTGATAAAGGTCCTGAGGATATGGCAGT
GATTCTATTCACATCAGGTACAGAGAAACTCCCTAAAGGAGTTCCTCTTACCAACGCCTCGTTACTTGCTAACCAAAAAG
CTTGTTTCGATTTCTTCTCTCCTGAAGAAGACGATGTGATGATGTCTTTTCTCCCCCCATTCCATGCTTATGGGTTTAAT
TCCTGTACGTTGTTCCCATTGCTTTCTGGAGTGCCTGTTGTTTTCGCTTATAACCCTCTTTATGCCAAGAAAATAGTAGA
AATGGTTGATGAGGCGAAAGTTACGTTGCTAGGAAGCACACCCGTTTTCTTCAGCTATATTCTTACTGCTGCTAAAAAAA
GTGAGACTTCACTTCCTTCTTTGAGGTTTGTTGTTATTGGAGGAGATGTTTTCAAACACTCTTTATATCAAGAGGCTTTA
AAAACATTCCCACACGTGCAATTACGTCAAGGATATGGAACCACGGAATGCTCACCGGTCATTACTATCAATACAGTAAA
TAGCCCGAAACATGAGTCTTGTGTAGGGATTCCTGTTAGAGGGATGGAAGTTTTAATTGTTTCTGAAGAGACTAAAGCCC
CAGTACCAACAGGTGTCACTGGACTGGTATTAACTCGAGGAACTTCTCTATTCAAAGGATATCTTGGAGAAGATTTCGGG
CATGGGTTCATAGAATTGGATGGAGAGACATGGTATGTAACCGGAGATTTAGGTTATGTAGATCGCCATGGGGAGTTATT
CCTAAAAGGACGACTGAGTCGTTTCGTGAAGATTGGTGCGGAAATGGTCAGTCTTGAAGCTATGGAAAGCATTTTAATAG
AGGGATGTGGACAAAATGAAGCTGATCATCCTTTAGTTGTGTGTGGGCTTCCAGGAGAAAAAGAGCGTCTATGCCTTTTC
ACAATATTCCCCACGTCTATTCAGGAAGTAAATGATATCCTAAAAAACTCAAAAACAAGTAACTTACTAAAAATTTCTTA
TCACCATCAAGTAGAAGCAATCCCTATGTTAGGGACTGGGAAACCGGATTACTGCTCACTAAATGCTTTAGCAAAACGGT
TATTTGGCGAATAA

Upstream 100 bases:

>100_bases
CAGTTCCCGACAAAACAGGAATTCAATACTTTCCTCTCGGATTGGTTTAATCAGAAGGGTGGGGAGACTCCTTTAGAAGT
CCCCTACACATAGGTAAAAG

Downstream 100 bases:

>100_bases
GGACTTCTTTTTAGATTGTTATAGTTATGAGGAAAATGAGTTTTGAAGGGGTCGCGTTCTATTGATTTTATTACCAATGA
TTTCCTTGGTTTTTCTCGTT

Product: long chain fatty acid--[acyl-carrier-protein] ligase

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MRDNRNTAKHKRGKLRSEKTVLCSFLKLCAEMTTATVFWDEQLGKLSYNQVYKAVCALATRLAKYPDEHIGIMMPASSGA
YIAYFATLLSGKIPVMINWSQGLREVTACANLVGVKHVITAKPLMQKLAQTHGENAEYPFSLIFLEEIRKELTFLDKCRV
GICMSMPFEWMMRWFGSFDKGPEDMAVILFTSGTEKLPKGVPLTNASLLANQKACFDFFSPEEDDVMMSFLPPFHAYGFN
SCTLFPLLSGVPVVFAYNPLYAKKIVEMVDEAKVTLLGSTPVFFSYILTAAKKSETSLPSLRFVVIGGDVFKHSLYQEAL
KTFPHVQLRQGYGTTECSPVITINTVNSPKHESCVGIPVRGMEVLIVSEETKAPVPTGVTGLVLTRGTSLFKGYLGEDFG
HGFIELDGETWYVTGDLGYVDRHGELFLKGRLSRFVKIGAEMVSLEAMESILIEGCGQNEADHPLVVCGLPGEKERLCLF
TIFPTSIQEVNDILKNSKTSNLLKISYHHQVEAIPMLGTGKPDYCSLNALAKRLFGE

Sequences:

>Translated_537_residues
MRDNRNTAKHKRGKLRSEKTVLCSFLKLCAEMTTATVFWDEQLGKLSYNQVYKAVCALATRLAKYPDEHIGIMMPASSGA
YIAYFATLLSGKIPVMINWSQGLREVTACANLVGVKHVITAKPLMQKLAQTHGENAEYPFSLIFLEEIRKELTFLDKCRV
GICMSMPFEWMMRWFGSFDKGPEDMAVILFTSGTEKLPKGVPLTNASLLANQKACFDFFSPEEDDVMMSFLPPFHAYGFN
SCTLFPLLSGVPVVFAYNPLYAKKIVEMVDEAKVTLLGSTPVFFSYILTAAKKSETSLPSLRFVVIGGDVFKHSLYQEAL
KTFPHVQLRQGYGTTECSPVITINTVNSPKHESCVGIPVRGMEVLIVSEETKAPVPTGVTGLVLTRGTSLFKGYLGEDFG
HGFIELDGETWYVTGDLGYVDRHGELFLKGRLSRFVKIGAEMVSLEAMESILIEGCGQNEADHPLVVCGLPGEKERLCLF
TIFPTSIQEVNDILKNSKTSNLLKISYHHQVEAIPMLGTGKPDYCSLNALAKRLFGE
>Mature_537_residues
MRDNRNTAKHKRGKLRSEKTVLCSFLKLCAEMTTATVFWDEQLGKLSYNQVYKAVCALATRLAKYPDEHIGIMMPASSGA
YIAYFATLLSGKIPVMINWSQGLREVTACANLVGVKHVITAKPLMQKLAQTHGENAEYPFSLIFLEEIRKELTFLDKCRV
GICMSMPFEWMMRWFGSFDKGPEDMAVILFTSGTEKLPKGVPLTNASLLANQKACFDFFSPEEDDVMMSFLPPFHAYGFN
SCTLFPLLSGVPVVFAYNPLYAKKIVEMVDEAKVTLLGSTPVFFSYILTAAKKSETSLPSLRFVVIGGDVFKHSLYQEAL
KTFPHVQLRQGYGTTECSPVITINTVNSPKHESCVGIPVRGMEVLIVSEETKAPVPTGVTGLVLTRGTSLFKGYLGEDFG
HGFIELDGETWYVTGDLGYVDRHGELFLKGRLSRFVKIGAEMVSLEAMESILIEGCGQNEADHPLVVCGLPGEKERLCLF
TIFPTSIQEVNDILKNSKTSNLLKISYHHQVEAIPMLGTGKPDYCSLNALAKRLFGE

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=265, Percent_Identity=27.1698113207547, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789201, Length=500, Percent_Identity=28.2, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI145693145, Length=349, Percent_Identity=28.3667621776504, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788107, Length=312, Percent_Identity=24.3589743589744, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1786810, Length=509, Percent_Identity=23.1827111984283, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI221142682, Length=301, Percent_Identity=26.2458471760797, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560308, Length=304, Percent_Identity=27.6315789473684, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=370, Percent_Identity=25.9459459459459, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994703, Length=472, Percent_Identity=24.364406779661, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=472, Percent_Identity=24.364406779661, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=446, Percent_Identity=24.4394618834081, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17557194, Length=380, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531443, Length=358, Percent_Identity=25.1396648044693, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17558820, Length=271, Percent_Identity=26.9372693726937, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17538037, Length=377, Percent_Identity=25.4641909814324, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560140, Length=332, Percent_Identity=23.7951807228916, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32563687, Length=278, Percent_Identity=26.2589928057554, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71985884, Length=296, Percent_Identity=24.6621621621622, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=294, Percent_Identity=25.5102040816327, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18859661, Length=302, Percent_Identity=25.1655629139073, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355181, Length=429, Percent_Identity=23.0769230769231, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24648260, Length=278, Percent_Identity=29.8561151079137, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI20130357, Length=279, Percent_Identity=27.5985663082437, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281365686, Length=277, Percent_Identity=22.7436823104693, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648253, Length=303, Percent_Identity=25.7425742574257, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648255, Length=303, Percent_Identity=26.0726072607261, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24581924, Length=462, Percent_Identity=21.4285714285714, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922652, Length=293, Percent_Identity=25.2559726962457, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356441, Length=298, Percent_Identity=24.8322147651007, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21358303, Length=302, Percent_Identity=23.841059602649, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24648676, Length=376, Percent_Identity=25.531914893617, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 59557; Mature: 59557

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDNRNTAKHKRGKLRSEKTVLCSFLKLCAEMTTATVFWDEQLGKLSYNQVYKAVCALAT
CCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEEHHHHCCCCHHHHHHHHHHHHH
RLAKYPDEHIGIMMPASSGAYIAYFATLLSGKIPVMINWSQGLREVTACANLVGVKHVIT
HHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHH
AKPLMQKLAQTHGENAEYPFSLIFLEEIRKELTFLDKCRVGICMSMPFEWMMRWFGSFDK
HHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCC
GPEDMAVILFTSGTEKLPKGVPLTNASLLANQKACFDFFSPEEDDVMMSFLPPFHAYGFN
CCCCEEEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHCCCCCCCCCCEECCCCHHHCCCC
SCTLFPLLSGVPVVFAYNPLYAKKIVEMVDEAKVTLLGSTPVFFSYILTAAKKSETSLPS
CEEHHHHHCCCCEEEEECHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCC
LRFVVIGGDVFKHSLYQEALKTFPHVQLRQGYGTTECSPVITINTVNSPKHESCVGIPVR
EEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCCCCEECCCCC
GMEVLIVSEETKAPVPTGVTGLVLTRGTSLFKGYLGEDFGHGFIELDGETWYVTGDLGYV
CEEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCEEEECCCEEEEECCCCCC
DRHGELFLKGRLSRFVKIGAEMVSLEAMESILIEGCGQNEADHPLVVCGLPGEKERLCLF
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCEEEE
TIFPTSIQEVNDILKNSKTSNLLKISYHHQVEAIPMLGTGKPDYCSLNALAKRLFGE
EECCCCHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCEEHHHHHHHHCCC
>Mature Secondary Structure
MRDNRNTAKHKRGKLRSEKTVLCSFLKLCAEMTTATVFWDEQLGKLSYNQVYKAVCALAT
CCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEEHHHHCCCCHHHHHHHHHHHHH
RLAKYPDEHIGIMMPASSGAYIAYFATLLSGKIPVMINWSQGLREVTACANLVGVKHVIT
HHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHH
AKPLMQKLAQTHGENAEYPFSLIFLEEIRKELTFLDKCRVGICMSMPFEWMMRWFGSFDK
HHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCC
GPEDMAVILFTSGTEKLPKGVPLTNASLLANQKACFDFFSPEEDDVMMSFLPPFHAYGFN
CCCCEEEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHCCCCCCCCCCEECCCCHHHCCCC
SCTLFPLLSGVPVVFAYNPLYAKKIVEMVDEAKVTLLGSTPVFFSYILTAAKKSETSLPS
CEEHHHHHCCCCEEEEECHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCC
LRFVVIGGDVFKHSLYQEALKTFPHVQLRQGYGTTECSPVITINTVNSPKHESCVGIPVR
EEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCCCCEECCCCC
GMEVLIVSEETKAPVPTGVTGLVLTRGTSLFKGYLGEDFGHGFIELDGETWYVTGDLGYV
CEEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCEEEECCCEEEEECCCCCC
DRHGELFLKGRLSRFVKIGAEMVSLEAMESILIEGCGQNEADHPLVVCGLPGEKERLCLF
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCEEEE
TIFPTSIQEVNDILKNSKTSNLLKISYHHQVEAIPMLGTGKPDYCSLNALAKRLFGE
EECCCCHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA