Click here to switch to the map view.

The map label for this gene is hemE

Identifier: 15834747

GI number: 15834747

Start: 148298

End: 149302

Strand: Reverse

Name: hemE

Synonym: TC0123

Alternate gene names: 15834747

Gene position: 149302-148298 (Counterclockwise)

Preceding gene: 15834748

Following gene: 15834746

Centisome position: 13.92

GC content: 40.0

Gene sequence:

>1005_bases
ATGGCGGGCTTTTATGACATCATCTCCCCTAGTAATCAACACCGCCCTCCTGTATGGCTCCTTCGTCAAGTGGGGCGATA
CATGCCTCAATATCAAGAATTAAAAACCAATCGCCCTCTAAAGGAACTTTTCCTCGACACAGAATCTATTATAGAAGCAA
CTTTGCTAGGGCCTTCTTTATTAGGAGTCGATGCTGCTATTGTTTTTACAGATATCCTCTCTATTCTAGAAGGATTTGCA
ATAGAGTATCGCTTTGCTCCTGGGCCAGAGATTATTTATTCCCCCCATCAGCCTTTTGTTTTCACTGAGGATCCTTTTTC
TACTTTCTCATTTCTAATTGAAGCTATCCAGAAACTCACAAAACGATTAACTGTCCCTCTGATAGCCTTTGCTGCCTCGC
CATTCACTCTCGCTAGTTATCTCATAGAAGGTGGAGCATCTAAAGACTGTTCTAAAACCATAGCTTTCCTTTATCAGTAC
CCTGATAAATTCGAAGCTTTGTTAAATGAAATTATTAAAGGCACAGCCATTTATCTCCAGCTACAAGTACAAGCAGGAGC
TTCAGCTGTACAACTTTTTGAATCTTCTAGTTTACGACTACCTCCCAGCCTATTTTCAAAATATGTAGTCTCCCCCAATG
CCAAACTCATTCGATTAATCAAACAGAGAGAAAATCCTCCTGTTAGTCTATTCTGCCGATGTTTTTATCAAGAATTTTTA
TCTTTATATGCAACAGGTGCAGATACGCTCCATCCTGATTATCACGTAGAACTCTCAGAAATTTATCGCCAGTTAGGAGA
TCCTGGGTCTATTCAAGGAAATTTCGATCCCGCTCTTCTACTTCTCCCCCAAGACTTACTGATTGCACATCTCGAAACCT
ATCTTGCTCCCCTAAAACAGCAATCGCATTATATTTTCAATTTAGGACATGGTATCTTACCTCAAACGCCATTAGAAAAT
GTACAGGCTGTCGTCAAATGTTTAACATCAATTTCAACTTCCTAA

Upstream 100 bases:

>100_bases
CCTTATTCTTTGTCCCCAACACCAACACTTTTGGTGAAAGAGGTCCAAGAATCTATAGAAAAAGCTTTCCCCAAAAAATA
ATAGAGACGGAGGATTCCAG

Downstream 100 bases:

>100_bases
AAGGGCTTCATCAACCGGCCCCTCGCTACACGAGTTATCCCACTATCGTCGATTGGGAAGCATCCCAAGATTATGGTTAT
ACAGCCTTAAAAAACCTGGC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAGFYDIISPSNQHRPPVWLLRQVGRYMPQYQELKTNRPLKELFLDTESIIEATLLGPSLLGVDAAIVFTDILSILEGFA
IEYRFAPGPEIIYSPHQPFVFTEDPFSTFSFLIEAIQKLTKRLTVPLIAFAASPFTLASYLIEGGASKDCSKTIAFLYQY
PDKFEALLNEIIKGTAIYLQLQVQAGASAVQLFESSSLRLPPSLFSKYVVSPNAKLIRLIKQRENPPVSLFCRCFYQEFL
SLYATGADTLHPDYHVELSEIYRQLGDPGSIQGNFDPALLLLPQDLLIAHLETYLAPLKQQSHYIFNLGHGILPQTPLEN
VQAVVKCLTSISTS

Sequences:

>Translated_334_residues
MAGFYDIISPSNQHRPPVWLLRQVGRYMPQYQELKTNRPLKELFLDTESIIEATLLGPSLLGVDAAIVFTDILSILEGFA
IEYRFAPGPEIIYSPHQPFVFTEDPFSTFSFLIEAIQKLTKRLTVPLIAFAASPFTLASYLIEGGASKDCSKTIAFLYQY
PDKFEALLNEIIKGTAIYLQLQVQAGASAVQLFESSSLRLPPSLFSKYVVSPNAKLIRLIKQRENPPVSLFCRCFYQEFL
SLYATGADTLHPDYHVELSEIYRQLGDPGSIQGNFDPALLLLPQDLLIAHLETYLAPLKQQSHYIFNLGHGILPQTPLEN
VQAVVKCLTSISTS
>Mature_333_residues
AGFYDIISPSNQHRPPVWLLRQVGRYMPQYQELKTNRPLKELFLDTESIIEATLLGPSLLGVDAAIVFTDILSILEGFAI
EYRFAPGPEIIYSPHQPFVFTEDPFSTFSFLIEAIQKLTKRLTVPLIAFAASPFTLASYLIEGGASKDCSKTIAFLYQYP
DKFEALLNEIIKGTAIYLQLQVQAGASAVQLFESSSLRLPPSLFSKYVVSPNAKLIRLIKQRENPPVSLFCRCFYQEFLS
LYATGADTLHPDYHVELSEIYRQLGDPGSIQGNFDPALLLLPQDLLIAHLETYLAPLKQQSHYIFNLGHGILPQTPLENV
QAVVKCLTSISTS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=335, Percent_Identity=30.7462686567164, Blast_Score=142, Evalue=3e-34,
Organism=Escherichia coli, GI2367337, Length=330, Percent_Identity=30.6060606060606, Blast_Score=164, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6320252, Length=325, Percent_Identity=27.0769230769231, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI19921920, Length=333, Percent_Identity=33.6336336336336, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI221330099, Length=333, Percent_Identity=33.6336336336336, Blast_Score=164, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_CHLMU (Q9PLH7)

Other databases:

- EMBL:   AE002160
- PIR:   F81739
- RefSeq:   NP_296506.1
- ProteinModelPortal:   Q9PLH7
- SMR:   Q9PLH7
- GeneID:   1245657
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0123
- TIGR:   TC_0123
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   CMUR243161:TC_0123-MONOMER
- BRENDA:   4.1.1.37
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37381; Mature: 37249

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 71-71 BINDING 140-140 BINDING 195-195 BINDING 310-310

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGFYDIISPSNQHRPPVWLLRQVGRYMPQYQELKTNRPLKELFLDTESIIEATLLGPSL
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCHHHHHCCHHHHHHHHHCCCHH
LGVDAAIVFTDILSILEGFAIEYRFAPGPEIIYSPHQPFVFTEDPFSTFSFLIEAIQKLT
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCCCCEEEECCCHHHHHHHHHHHHHHH
KRLTVPLIAFAASPFTLASYLIEGGASKDCSKTIAFLYQYPDKFEALLNEIIKGTAIYLQ
HHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEE
LQVQAGASAVQLFESSSLRLPPSLFSKYVVSPNAKLIRLIKQRENPPVSLFCRCFYQEFL
EEECCCCHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
SLYATGADTLHPDYHVELSEIYRQLGDPGSIQGNFDPALLLLPQDLLIAHLETYLAPLKQ
HHHHCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHH
QSHYIFNLGHGILPQTPLENVQAVVKCLTSISTS
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AGFYDIISPSNQHRPPVWLLRQVGRYMPQYQELKTNRPLKELFLDTESIIEATLLGPSL
CCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCHHHHHCCHHHHHHHHHCCCHH
LGVDAAIVFTDILSILEGFAIEYRFAPGPEIIYSPHQPFVFTEDPFSTFSFLIEAIQKLT
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCCCCEEEECCCHHHHHHHHHHHHHHH
KRLTVPLIAFAASPFTLASYLIEGGASKDCSKTIAFLYQYPDKFEALLNEIIKGTAIYLQ
HHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEE
LQVQAGASAVQLFESSSLRLPPSLFSKYVVSPNAKLIRLIKQRENPPVSLFCRCFYQEFL
EEECCCCHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
SLYATGADTLHPDYHVELSEIYRQLGDPGSIQGNFDPALLLLPQDLLIAHLETYLAPLKQ
HHHHCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHH
QSHYIFNLGHGILPQTPLENVQAVVKCLTSISTS
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935