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The map label for this gene is hemN

Identifier: 15834746

GI number: 15834746

Start: 146952

End: 148325

Strand: Reverse

Name: hemN

Synonym: TC0122

Alternate gene names: 15834746

Gene position: 148325-146952 (Counterclockwise)

Preceding gene: 15834747

Following gene: 15834745

Centisome position: 13.82

GC content: 39.81

Gene sequence:

>1374_bases
ATGTTTAACATCAATTTCAACTTCCTAAAAGGGCTTCATCAACCGGCCCCTCGCTACACGAGTTATCCCACTATCGTCGA
TTGGGAAGCATCCCAAGATTATGGTTATACAGCCTTAAAAAACCTGGCTGATGAGCACCAGCCTCTTTCTTTATACTTCC
ACATCCCCTTCTGCCAATCTATGTGCCTTTATTGCGGGTGCTCTGTTGTTTTAAATAGAAAAGAGGAGATTGTGGATCAT
TACATAGAATCCTTGATTCAAGAAATGCGTCTCACATTCTCTTTGTTAGGAGGGAAAAAGCCTGTTTCTAGAATTCACTT
TGGAGGAGGAACTCCTAGTCGTCTATCACGAGCTCAATTCACACACCTATTTACTCATATTCATCAATTTTTTGATCTCT
CTAATATCGAAGAACTTGCTATTGAATTTGATCCACGTAGCCTACGAGAAGATGCAGATAAACCCCTATTTCTTCAGAAC
CTTGGATTTAATCGTGTCAGCCTTGGAATCCAAGATACTCAATGGGAAGTTCAAGAGGCCGTCCGTAGACGCCAATCCTA
TGAAGAATCCCTCTTGGCCTATAAACAATTCCGTGATCTGAATTTCACAGGTATCAATATTGATCTTATTTATGGGCTTC
CTAAACAAACGCAATCGAGTTTCAAACAAACCATTCAACATATTTTAGATATGCGGCCTGATCGCTTAGCCCTATTCTCT
TTTGCACATGTGCCATGGGTCAAGCCTCATCAAAAAGCTTTACGAACAAAAGACCTTCCCTCTATGGAAGAGAAATTTGC
GATTTATTCTCAATCTCGACAAGCCCTTATCCAAGAAGGATACCAGGCTATTGGCCTTGATCATTTTTCTCTTCCTGATG
ATCCCCTAACTATTGCACTTAAAAACAAAACCCTTATTCGAAATTTTCAAGGGTATTCCCTTCCTCCTGAAGAAGATCTT
TTAGGATTTGGCTTGTCAGCAACTAGCTTTATTCGAGGCATTTACTTACAGAATTCTAAAGATCTTCGTGAATATTCCAC
GACCATCCATTCCGGAAAACTTGCTACTGTAAAAGGAAAAATCCTTTCTCAAGACGATAAAATCCGCAAATGGGTCATTC
ATACTCTGATGTGTTCTTTTTCTTTATCTAAGCTCGAGTTTGAGCAACTTTTCCATGAACGATTTGATCTATACTTTGCT
GATAGCTACGATCGGTTATGCGGGATGGAAAGTGCTGGCCTAATCCGCCAAGACTCTTCCTCTTTACAAGTCACTCCTCT
TGGAGAGCTTTTTGTACGAGTAATTGCTACGGCTTTTGATTATTACTTTCTGAAAAACGTTGCAGAAAAACCGATTTTTT
CAAAATCCATATGA

Upstream 100 bases:

>100_bases
CCTATCTTGCTCCCCTAAAACAGCAATCGCATTATATTTTCAATTTAGGACATGGTATCTTACCTCAAACGCCATTAGAA
AATGTACAGGCTGTCGTCAA

Downstream 100 bases:

>100_bases
AACATGCATTAGTTGTTGGTTCTGGTATTGCAGGACTCTCTGCAGCATGGTGGCTGCACAAACGCTTCCCACATATGCAA
TTGTCCATCCTAGAAAAAGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MFNINFNFLKGLHQPAPRYTSYPTIVDWEASQDYGYTALKNLADEHQPLSLYFHIPFCQSMCLYCGCSVVLNRKEEIVDH
YIESLIQEMRLTFSLLGGKKPVSRIHFGGGTPSRLSRAQFTHLFTHIHQFFDLSNIEELAIEFDPRSLREDADKPLFLQN
LGFNRVSLGIQDTQWEVQEAVRRRQSYEESLLAYKQFRDLNFTGINIDLIYGLPKQTQSSFKQTIQHILDMRPDRLALFS
FAHVPWVKPHQKALRTKDLPSMEEKFAIYSQSRQALIQEGYQAIGLDHFSLPDDPLTIALKNKTLIRNFQGYSLPPEEDL
LGFGLSATSFIRGIYLQNSKDLREYSTTIHSGKLATVKGKILSQDDKIRKWVIHTLMCSFSLSKLEFEQLFHERFDLYFA
DSYDRLCGMESAGLIRQDSSSLQVTPLGELFVRVIATAFDYYFLKNVAEKPIFSKSI

Sequences:

>Translated_457_residues
MFNINFNFLKGLHQPAPRYTSYPTIVDWEASQDYGYTALKNLADEHQPLSLYFHIPFCQSMCLYCGCSVVLNRKEEIVDH
YIESLIQEMRLTFSLLGGKKPVSRIHFGGGTPSRLSRAQFTHLFTHIHQFFDLSNIEELAIEFDPRSLREDADKPLFLQN
LGFNRVSLGIQDTQWEVQEAVRRRQSYEESLLAYKQFRDLNFTGINIDLIYGLPKQTQSSFKQTIQHILDMRPDRLALFS
FAHVPWVKPHQKALRTKDLPSMEEKFAIYSQSRQALIQEGYQAIGLDHFSLPDDPLTIALKNKTLIRNFQGYSLPPEEDL
LGFGLSATSFIRGIYLQNSKDLREYSTTIHSGKLATVKGKILSQDDKIRKWVIHTLMCSFSLSKLEFEQLFHERFDLYFA
DSYDRLCGMESAGLIRQDSSSLQVTPLGELFVRVIATAFDYYFLKNVAEKPIFSKSI
>Mature_457_residues
MFNINFNFLKGLHQPAPRYTSYPTIVDWEASQDYGYTALKNLADEHQPLSLYFHIPFCQSMCLYCGCSVVLNRKEEIVDH
YIESLIQEMRLTFSLLGGKKPVSRIHFGGGTPSRLSRAQFTHLFTHIHQFFDLSNIEELAIEFDPRSLREDADKPLFLQN
LGFNRVSLGIQDTQWEVQEAVRRRQSYEESLLAYKQFRDLNFTGINIDLIYGLPKQTQSSFKQTIQHILDMRPDRLALFS
FAHVPWVKPHQKALRTKDLPSMEEKFAIYSQSRQALIQEGYQAIGLDHFSLPDDPLTIALKNKTLIRNFQGYSLPPEEDL
LGFGLSATSFIRGIYLQNSKDLREYSTTIHSGKLATVKGKILSQDDKIRKWVIHTLMCSFSLSKLEFEQLFHERFDLYFA
DSYDRLCGMESAGLIRQDSSSLQVTPLGELFVRVIATAFDYYFLKNVAEKPIFSKSI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=243, Percent_Identity=25.1028806584362, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI87082341, Length=444, Percent_Identity=39.8648648648649, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1789325, Length=246, Percent_Identity=27.6422764227642, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52798; Mature: 52798

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNINFNFLKGLHQPAPRYTSYPTIVDWEASQDYGYTALKNLADEHQPLSLYFHIPFCQS
CCCCCHHHHHHCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCEEEEEECHHHHH
MCLYCGCSVVLNRKEEIVDHYIESLIQEMRLTFSLLGGKKPVSRIHFGGGTPSRLSRAQF
HHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHH
THLFTHIHQFFDLSNIEELAIEFDPRSLREDADKPLFLQNLGFNRVSLGIQDTQWEVQEA
HHHHHHHHHHHCCCCHHHHHEECCCHHHHHCCCCCEEECCCCCCEEEECCCCCHHHHHHH
VRRRQSYEESLLAYKQFRDLNFTGINIDLIYGLPKQTQSSFKQTIQHILDMRPDRLALFS
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHH
FAHVPWVKPHQKALRTKDLPSMEEKFAIYSQSRQALIQEGYQAIGLDHFSLPDDPLTIAL
HHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCEEEEE
KNKTLIRNFQGYSLPPEEDLLGFGLSATSFIRGIYLQNSKDLREYSTTIHSGKLATVKGK
CCCHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECC
ILSQDDKIRKWVIHTLMCSFSLSKLEFEQLFHERFDLYFADSYDRLCGMESAGLIRQDSS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCHHHHHCCCCCCCEECCCC
SLQVTPLGELFVRVIATAFDYYFLKNVAEKPIFSKSI
CEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFNINFNFLKGLHQPAPRYTSYPTIVDWEASQDYGYTALKNLADEHQPLSLYFHIPFCQS
CCCCCHHHHHHCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCEEEEEECHHHHH
MCLYCGCSVVLNRKEEIVDHYIESLIQEMRLTFSLLGGKKPVSRIHFGGGTPSRLSRAQF
HHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHH
THLFTHIHQFFDLSNIEELAIEFDPRSLREDADKPLFLQNLGFNRVSLGIQDTQWEVQEA
HHHHHHHHHHHCCCCHHHHHEECCCHHHHHCCCCCEEECCCCCCEEEECCCCCHHHHHHH
VRRRQSYEESLLAYKQFRDLNFTGINIDLIYGLPKQTQSSFKQTIQHILDMRPDRLALFS
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHH
FAHVPWVKPHQKALRTKDLPSMEEKFAIYSQSRQALIQEGYQAIGLDHFSLPDDPLTIAL
HHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCEEEEE
KNKTLIRNFQGYSLPPEEDLLGFGLSATSFIRGIYLQNSKDLREYSTTIHSGKLATVKGK
CCCHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECC
ILSQDDKIRKWVIHTLMCSFSLSKLEFEQLFHERFDLYFADSYDRLCGMESAGLIRQDSS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCHHHHHCCCCCCCEECCCC
SLQVTPLGELFVRVIATAFDYYFLKNVAEKPIFSKSI
CEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]