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The map label for this gene is hemY

Identifier: 15834745

GI number: 15834745

Start: 145681

End: 146955

Strand: Reverse

Name: hemY

Synonym: TC0121

Alternate gene names: 15834745

Gene position: 146955-145681 (Counterclockwise)

Preceding gene: 15834746

Following gene: 15834743

Centisome position: 13.7

GC content: 42.75

Gene sequence:

>1275_bases
ATGAAACATGCATTAGTTGTTGGTTCTGGTATTGCAGGACTCTCTGCAGCATGGTGGCTGCACAAACGCTTCCCACATAT
GCAATTGTCCATCCTAGAAAAAGAATCTCGTCCGGGAGGACTTGTCGTCACTGAGAAACAAAAAGGTCTTTTTTTCAATA
TGGGACCTAAGGGCTTTGTTGTATCCCATGATGGGAAGCATACCCTCCATCTCATCCAGTCTGTGGGCTTATCAGACGAT
CTTATATATAGCTCCCCCGCAGCTAAACATCGGTTTATTCACTATAAAAATAAAACTCGAAAAGTTTCTCCTTGGACAAT
TTTTAAACAGAATCTCCCTCTTACTCTTATTAAAGACTTATTTGCTCGTCCTTATAAACAAGATAGCTCTGTAGAAGCTT
TTTTCAAAAGGCACAGCTCTACCAAGCTAAGAACACACCTTCTAAACCCTATTAATCTGGCTATGCGAGCAGGACATAGT
CATATACTGTCTGCACAAATGGCTTACCCAGAATTAACTCGGCGAGAAGCTGAGATGGGATCTTTACTACGTAGTTATCT
CAGAGATTTCCCTAGAACCGCTCGGAAAGGCCCTTATCTAGCTACCTTACGTTCTGGAATGGAAAGTTTAATCCAAACGC
TGCATGATAAACTTCCCGCTACATGGTACTTCTCCACGCCTGTTACGAAAATTCGTCAGTTATCTAATGGGAAAATCTCT
CTTTCTTCTTCTCAGGGAGAGATAACCGGAGATATACTCATTTATGCTGGATCTGTTCAAGATCTCCCTTCTTGCTTAGA
AGAGATTCCTGAATCTGCACTAGTGAAACAAACCACCTCTTCTTGGGATCTTTCTTGTGTAGCCTTAGGATGGCATAGTT
CGCTCCCCCTCCCTCATGGATATGGCATGCTTTTTGCAGATACGCCTCCTTTACTTGGGATCGTTTTTAACACAGAAGTA
TTTCCCAATTCTCAGCAACCTAGCACGACTCTCTCTCTCCTTTTAGAAGGGCGGTGGCACCAAGAAGAAGCTTACGCATT
CTCTCTAGCAACCATTTCTGAGTATCTGCAAATTTATACCCCTCCTCAAGCCTTTTCGCTATTTTCTCCTAAAGAAGGGC
TCCCTCAGCATCATGTTGGATTTATTCGATCGCGAAAAATTCTCTTATCCAAACTTCCCCCAAACATAAAAATTGTGGGA
CAAAATTTTGCTGGACCAGGACTGAACCGTGCAACAGCATCCGCCTACGAATCTATTGCTTCTTTACGACCATGA

Upstream 100 bases:

>100_bases
TCACTCCTCTTGGAGAGCTTTTTGTACGAGTAATTGCTACGGCTTTTGATTATTACTTTCTGAAAAACGTTGCAGAAAAA
CCGATTTTTTCAAAATCCAT

Downstream 100 bases:

>100_bases
AGAATCTGCTACTAATAACTCCTTGCATAAAGAACTTGTCACGGAGAGCATTTTCCCTATGTATTCCTGTCTTGAACGCG
TTTGGAACAAACGTTTTTCA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKHALVVGSGIAGLSAAWWLHKRFPHMQLSILEKESRPGGLVVTEKQKGLFFNMGPKGFVVSHDGKHTLHLIQSVGLSDD
LIYSSPAAKHRFIHYKNKTRKVSPWTIFKQNLPLTLIKDLFARPYKQDSSVEAFFKRHSSTKLRTHLLNPINLAMRAGHS
HILSAQMAYPELTRREAEMGSLLRSYLRDFPRTARKGPYLATLRSGMESLIQTLHDKLPATWYFSTPVTKIRQLSNGKIS
LSSSQGEITGDILIYAGSVQDLPSCLEEIPESALVKQTTSSWDLSCVALGWHSSLPLPHGYGMLFADTPPLLGIVFNTEV
FPNSQQPSTTLSLLLEGRWHQEEAYAFSLATISEYLQIYTPPQAFSLFSPKEGLPQHHVGFIRSRKILLSKLPPNIKIVG
QNFAGPGLNRATASAYESIASLRP

Sequences:

>Translated_424_residues
MKHALVVGSGIAGLSAAWWLHKRFPHMQLSILEKESRPGGLVVTEKQKGLFFNMGPKGFVVSHDGKHTLHLIQSVGLSDD
LIYSSPAAKHRFIHYKNKTRKVSPWTIFKQNLPLTLIKDLFARPYKQDSSVEAFFKRHSSTKLRTHLLNPINLAMRAGHS
HILSAQMAYPELTRREAEMGSLLRSYLRDFPRTARKGPYLATLRSGMESLIQTLHDKLPATWYFSTPVTKIRQLSNGKIS
LSSSQGEITGDILIYAGSVQDLPSCLEEIPESALVKQTTSSWDLSCVALGWHSSLPLPHGYGMLFADTPPLLGIVFNTEV
FPNSQQPSTTLSLLLEGRWHQEEAYAFSLATISEYLQIYTPPQAFSLFSPKEGLPQHHVGFIRSRKILLSKLPPNIKIVG
QNFAGPGLNRATASAYESIASLRP
>Mature_424_residues
MKHALVVGSGIAGLSAAWWLHKRFPHMQLSILEKESRPGGLVVTEKQKGLFFNMGPKGFVVSHDGKHTLHLIQSVGLSDD
LIYSSPAAKHRFIHYKNKTRKVSPWTIFKQNLPLTLIKDLFARPYKQDSSVEAFFKRHSSTKLRTHLLNPINLAMRAGHS
HILSAQMAYPELTRREAEMGSLLRSYLRDFPRTARKGPYLATLRSGMESLIQTLHDKLPATWYFSTPVTKIRQLSNGKIS
LSSSQGEITGDILIYAGSVQDLPSCLEEIPESALVKQTTSSWDLSCVALGWHSSLPLPHGYGMLFADTPPLLGIVFNTEV
FPNSQQPSTTLSLLLEGRWHQEEAYAFSLATISEYLQIYTPPQAFSLFSPKEGLPQHHVGFIRSRKILLSKLPPNIKIVG
QNFAGPGLNRATASAYESIASLRP

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. May have an essential extracellular function during development, possibly as a pheromone [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=374, Percent_Identity=23.7967914438503, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI4506001, Length=374, Percent_Identity=23.7967914438503, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 47261; Mature: 47261

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHALVVGSGIAGLSAAWWLHKRFPHMQLSILEKESRPGGLVVTEKQKGLFFNMGPKGFV
CCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCEEEECCCCCEE
VSHDGKHTLHLIQSVGLSDDLIYSSPAAKHRFIHYKNKTRKVSPWTIFKQNLPLTLIKDL
EECCCCHHHHHHHHCCCCCCEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHH
FARPYKQDSSVEAFFKRHSSTKLRTHLLNPINLAMRAGHSHILSAQMAYPELTRREAEMG
HCCCCCCCCHHHHHHHHCCCCHHHHHHCCHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHH
SLLRSYLRDFPRTARKGPYLATLRSGMESLIQTLHDKLPATWYFSTPVTKIRQLSNGKIS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCEEE
LSSSQGEITGDILIYAGSVQDLPSCLEEIPESALVKQTTSSWDLSCVALGWHSSLPLPHG
EECCCCCEEEEEEEEECCHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCC
YGMLFADTPPLLGIVFNTEVFPNSQQPSTTLSLLLEGRWHQEEAYAFSLATISEYLQIYT
CEEEEECCCCEEEEEEECEECCCCCCCCCEEHHEECCCCCCCHHHEEHHHHHHHHHHCCC
PPQAFSLFSPKEGLPQHHVGFIRSRKILLSKLPPNIKIVGQNFAGPGLNRATASAYESIA
CCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHH
SLRP
HCCC
>Mature Secondary Structure
MKHALVVGSGIAGLSAAWWLHKRFPHMQLSILEKESRPGGLVVTEKQKGLFFNMGPKGFV
CCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCEEEECCCCCEE
VSHDGKHTLHLIQSVGLSDDLIYSSPAAKHRFIHYKNKTRKVSPWTIFKQNLPLTLIKDL
EECCCCHHHHHHHHCCCCCCEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHH
FARPYKQDSSVEAFFKRHSSTKLRTHLLNPINLAMRAGHSHILSAQMAYPELTRREAEMG
HCCCCCCCCHHHHHHHHCCCCHHHHHHCCHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHH
SLLRSYLRDFPRTARKGPYLATLRSGMESLIQTLHDKLPATWYFSTPVTKIRQLSNGKIS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCEEE
LSSSQGEITGDILIYAGSVQDLPSCLEEIPESALVKQTTSSWDLSCVALGWHSSLPLPHG
EECCCCCEEEEEEEEECCHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCC
YGMLFADTPPLLGIVFNTEVFPNSQQPSTTLSLLLEGRWHQEEAYAFSLATISEYLQIYT
CEEEEECCCCEEEEEEECEECCCCCCCCCEEHHEECCCCCCCHHHEEHHHHHHHHHHCCC
PPQAFSLFSPKEGLPQHHVGFIRSRKILLSKLPPNIKIVGQNFAGPGLNRATASAYESIA
CCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHH
SLRP
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1372277; 8621504 [H]