Click here to switch to the map view.

The map label for this gene is ribG

Identifier: 15834728

GI number: 15834728

Start: 121759

End: 122949

Strand: Direct

Name: ribG

Synonym: TC0103

Alternate gene names: 15834728

Gene position: 121759-122949 (Clockwise)

Preceding gene: 15834723

Following gene: 15834729

Centisome position: 11.35

GC content: 46.18

Gene sequence:

>1191_bases
TTGGTTCCTTGCGTATTAATCGTATATCCAACATCCTTGCATCTCTTTCGCTATCTGATTTTTCAGGTTGAGTATATGGA
AGTTTCGTCTGAGCAACAACTGTTTTTTATGCGCGAGGCCGTTGCATTAGGTGAAAGGGGGAGGATTTTTGCTCCCCCTA
ATCCTTGGGTGGGGTGTGTGATTGTAAAAAATGGATGTATAATAGGAAGAGGGTGGCACAAAGGAATTGGGTCCCCGCAT
GCGGAAGTTTGTGCTTTCCAAGATCAAACTAGCTCATTGGTAGGAGCAGATGTGTATGTCACCTTAGAGCCTTGCTGCCA
TTTTGGTAGGACTCCCCCCTGCGTAGATCTTTTGATCAAAAGTAAGGTGTCGTCAGTTTATATTGCTCTGCTAGATCCTG
ACCCTCGTGTTTGTAAAAGGGGGGTTGCTCGTCTGAAGGAGGCGGGAATTTCTGTTTATGTGGGGATAGGTCACGAAGAA
GCAAAGGCTTCCTTGCAACCGTACTTGCATCAAAGAGAAACGGGGTTGCCATGGGTTGTTATGAAAACGGCCGCGTCTCT
CGATGGTCAAACCTCGGATCGTAGAGGGATATCGCAATGGATTTCAGGAGAGCAGGCTCGGTTAGATGTAGGAAGACTTC
GTGCTGAGTCCCAAGCTGTAATTGTCGGTTCGCGTACGGTGTGTTTAGATAATCCTCGTTTATCTGCTCGGATGCCTTCA
GGGGATTTGTACGAGAGACAACCGTTACGAGTAGTGGTGGATAGCAGAGGGAGTGTTCCTTTAGATGCTCGGGTATGGAA
TCCAGATTCTGGAAATGTTTTGCTTGCTACAACGGAACAGTGCTCTAAGGAGCATATTCAAAAATTAGAAGATCGGGGAG
TGGAGGTATGGAAATCTTCTCCCCAGCAGGTGGATCTCAAAAGACTTTTACAATATCTGGCAGAGAAAGGATGTCTACAA
GTGCTTGTTGAAGGGGGGGCTCGGTTGCACTCCGCTTTCTGGCGTGAGCATCTTGTGAACGCAGGTGTGATCTATTGGGG
CCCCAAATTTTTGGGGGATCAAGGTAGTCCTATGTTACGAGATCTTCAGTTATGTTTGGATAATGCAGAACATGTGAAAA
TCACAAAAACTTTTTTAGTTGGAGATTCTGTAAAGACATGTTTTGAATGCGTGGGGAGAGAGGATGGATAG

Upstream 100 bases:

>100_bases
TCTGAATCTGCTTTCAGTTGACGCACATTTTTATCTAAGTCTAGAAGGCGTTCTAACGAAATAGAGGGATCTTTTTTTTG
AAGACGGGCTTCACATTCTT

Downstream 100 bases:

>100_bases
GTGAGCTTAGGGTCGCAGAAAGTATAAGTTTGTGCTATACTCTGCACACAGCAAGGAGCTTGTATTAGAAAAACTTTCCA
CTAGCTGAGTTTTTCTCAAA

Product: riboflavin-specific deaminase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MVPCVLIVYPTSLHLFRYLIFQVEYMEVSSEQQLFFMREAVALGERGRIFAPPNPWVGCVIVKNGCIIGRGWHKGIGSPH
AEVCAFQDQTSSLVGADVYVTLEPCCHFGRTPPCVDLLIKSKVSSVYIALLDPDPRVCKRGVARLKEAGISVYVGIGHEE
AKASLQPYLHQRETGLPWVVMKTAASLDGQTSDRRGISQWISGEQARLDVGRLRAESQAVIVGSRTVCLDNPRLSARMPS
GDLYERQPLRVVVDSRGSVPLDARVWNPDSGNVLLATTEQCSKEHIQKLEDRGVEVWKSSPQQVDLKRLLQYLAEKGCLQ
VLVEGGARLHSAFWREHLVNAGVIYWGPKFLGDQGSPMLRDLQLCLDNAEHVKITKTFLVGDSVKTCFECVGREDG

Sequences:

>Translated_396_residues
MVPCVLIVYPTSLHLFRYLIFQVEYMEVSSEQQLFFMREAVALGERGRIFAPPNPWVGCVIVKNGCIIGRGWHKGIGSPH
AEVCAFQDQTSSLVGADVYVTLEPCCHFGRTPPCVDLLIKSKVSSVYIALLDPDPRVCKRGVARLKEAGISVYVGIGHEE
AKASLQPYLHQRETGLPWVVMKTAASLDGQTSDRRGISQWISGEQARLDVGRLRAESQAVIVGSRTVCLDNPRLSARMPS
GDLYERQPLRVVVDSRGSVPLDARVWNPDSGNVLLATTEQCSKEHIQKLEDRGVEVWKSSPQQVDLKRLLQYLAEKGCLQ
VLVEGGARLHSAFWREHLVNAGVIYWGPKFLGDQGSPMLRDLQLCLDNAEHVKITKTFLVGDSVKTCFECVGREDG
>Mature_396_residues
MVPCVLIVYPTSLHLFRYLIFQVEYMEVSSEQQLFFMREAVALGERGRIFAPPNPWVGCVIVKNGCIIGRGWHKGIGSPH
AEVCAFQDQTSSLVGADVYVTLEPCCHFGRTPPCVDLLIKSKVSSVYIALLDPDPRVCKRGVARLKEAGISVYVGIGHEE
AKASLQPYLHQRETGLPWVVMKTAASLDGQTSDRRGISQWISGEQARLDVGRLRAESQAVIVGSRTVCLDNPRLSARMPS
GDLYERQPLRVVVDSRGSVPLDARVWNPDSGNVLLATTEQCSKEHIQKLEDRGVEVWKSSPQQVDLKRLLQYLAEKGCLQ
VLVEGGARLHSAFWREHLVNAGVIYWGPKFLGDQGSPMLRDLQLCLDNAEHVKITKTFLVGDSVKTCFECVGREDG

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=373, Percent_Identity=39.142091152815, Blast_Score=227, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6319629, Length=211, Percent_Identity=27.9620853080569, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 43939; Mature: 43939

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPCVLIVYPTSLHLFRYLIFQVEYMEVSSEQQLFFMREAVALGERGRIFAPPNPWVGCV
CCCEEEEEECCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCCEECCCCCCEEEE
IVKNGCIIGRGWHKGIGSPHAEVCAFQDQTSSLVGADVYVTLEPCCHFGRTPPCVDLLIK
EEECCEEEECCHHCCCCCCCHHHEEECCCCCCEECCEEEEEEEHHHCCCCCCHHHHHHHH
SKVSSVYIALLDPDPRVCKRGVARLKEAGISVYVGIGHEEAKASLQPYLHQRETGLPWVV
HCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEE
MKTAASLDGQTSDRRGISQWISGEQARLDVGRLRAESQAVIVGSRTVCLDNPRLSARMPS
EEHHHCCCCCCCCHHHHHHHHCCCHHEEHHHHHCCCCCEEEEECEEEEECCCCCEEECCC
GDLYERQPLRVVVDSRGSVPLDARVWNPDSGNVLLATTEQCSKEHIQKLEDRGVEVWKSS
CCCCCCCCCEEEEECCCCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHCCC
PQQVDLKRLLQYLAEKGCLQVLVEGGARLHSAFWREHLVNAGVIYWGPKFLGDQGSPMLR
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECHHHCCCCCCHHHH
DLQLCLDNAEHVKITKTFLVGDSVKTCFECVGREDG
HHHHHHCCCCEEEEEEEEEECCCHHHHHHHHCCCCC
>Mature Secondary Structure
MVPCVLIVYPTSLHLFRYLIFQVEYMEVSSEQQLFFMREAVALGERGRIFAPPNPWVGCV
CCCEEEEEECCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCCEECCCCCCEEEE
IVKNGCIIGRGWHKGIGSPHAEVCAFQDQTSSLVGADVYVTLEPCCHFGRTPPCVDLLIK
EEECCEEEECCHHCCCCCCCHHHEEECCCCCCEECCEEEEEEEHHHCCCCCCHHHHHHHH
SKVSSVYIALLDPDPRVCKRGVARLKEAGISVYVGIGHEEAKASLQPYLHQRETGLPWVV
HCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEE
MKTAASLDGQTSDRRGISQWISGEQARLDVGRLRAESQAVIVGSRTVCLDNPRLSARMPS
EEHHHCCCCCCCCHHHHHHHHCCCHHEEHHHHHCCCCCEEEEECEEEEECCCCCEEECCC
GDLYERQPLRVVVDSRGSVPLDARVWNPDSGNVLLATTEQCSKEHIQKLEDRGVEVWKSS
CCCCCCCCCEEEEECCCCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHCCC
PQQVDLKRLLQYLAEKGCLQVLVEGGARLHSAFWREHLVNAGVIYWGPKFLGDQGSPMLR
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECHHHCCCCCCHHHH
DLQLCLDNAEHVKITKTFLVGDSVKTCFECVGREDG
HHHHHHCCCCEEEEEEEEEECCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]