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The map label for this gene is serS

Identifier: 15834727

GI number: 15834727

Start: 120506

End: 121792

Strand: Reverse

Name: serS

Synonym: TC0102

Alternate gene names: 15834727

Gene position: 121792-120506 (Counterclockwise)

Preceding gene: 15834731

Following gene: 15834726

Centisome position: 11.35

GC content: 40.95

Gene sequence:

>1287_bases
ATGTTGGATATACGATTAATACGCAAGGAACCAAAAGAATGTGAAGCCCGTCTTCAAAAAAAAGATCCCTCTATTTCGTT
AGAACGCCTTCTAGACTTAGATAAAAATGTGCGTCAACTGAAAGCAGATTCAGAGTCCTTACTTGCAAGACGTAAAGCTC
TTTCTGGCCAAATTCATAAAGCTAAAGTTGCTAACGAGGATGCCACTCCCCTTATTCAAGGGGTTAATGCTATTGCAGAC
CAACTTGTTGCTTTTGAAAAAACGTTACAAGAACAAGAAGCTCTTCTACTAGATCTCATGGCAAGACTGCCTAATTATCC
AGATGAGGACGTTCCTGTCTCCCCTGATAAATCGGGGAACAAAATTATTAAAAGCCACGGAGAAATTCCAACTTTTACCT
TTCCTCCTAAACACCATGTACAACTCAATGAAAAGCTGCAAATTTTAGATTTTAAACTTCCAGCCAAAACCTCAGGTTCC
GGCTGGCCAGCTTATAAAAATGAAGGCGTTCTTTTAGAATGGGCTCTGTTGACTTACCTTCTTAATAAGCAGCAAGCGCA
TGGATTTCAACTATGGCTTCCTCCACTACTTGTCAAACGCGATATTCTTTTTGGCTCAGGCCAAATTCCAAAATTTGATG
GGCAGTACTATCGTGTTGAAGACGGAGAGCAGTCTCTTTTCCTTATTCCAACAGCAGAAGTTGTTCTTAATGGATTCCAT
TCTCAAGAGATCTTAAACGAGCAAGATCTCCCTCTCTATTACGCAGCTTTTACCCCTTGTTTCCGCAGGGAAGCTGGTGC
TGGAGGATCTCATGAACGAGGATTAGTAAGAGTCCACCAATTCCATAAAGTAGAGATGTTTGCTTTTACAACCCCAGAAC
AAGAAGAGATTGCTTATCAAAAAATGATTGGCATTGTTGAAGAAATTCTTTCTGAACTTCAACTCCCTTACCAGCTCTCT
CTACTTTCTACAGGGGACATGTCTTTCACAGCCAAAAAAACGATCGATGCAGAGGTTTGGCTTCCAGGGCAACAAGCTTT
TTATGAGGTCTCTTCTATTTCCAAGTGTGGAGATTTTCAATCTCGTCGCTCTGAGACTCGCTATCGCGATGCTCAAGGCA
AATTACATTTCGTGAACACTCTAAATGGCTCAGGATTAGCAACTCCTAGATTGTTGGTAGCTATTTTAGAAAATTATCAA
CAAGAGGATGGATCCGTTGTGATTCCTCATGCGCTGCGCCCTTATATGAATAACCAAGAAATTCTCCTACCCAAAACAGA
TAGATAA

Upstream 100 bases:

>100_bases
TCACCTAATGCAACGGCCTCGCGCATAAAAAACAGTTGTTGCTCAGACGAAACTTCCATATACTCAACCTGAAAAATCAG
ATAGCGAAAGAGATGCAAGG

Downstream 100 bases:

>100_bases
TTCTATAGTGAGATCGAAAGGGACAAGAGATAGAATTTATGACATCGGAATATGAACACTTTGGGAACTTATCCCCAGAA
GAACATATTAAAGACGTGCA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLDIRLIRKEPKECEARLQKKDPSISLERLLDLDKNVRQLKADSESLLARRKALSGQIHKAKVANEDATPLIQGVNAIAD
QLVAFEKTLQEQEALLLDLMARLPNYPDEDVPVSPDKSGNKIIKSHGEIPTFTFPPKHHVQLNEKLQILDFKLPAKTSGS
GWPAYKNEGVLLEWALLTYLLNKQQAHGFQLWLPPLLVKRDILFGSGQIPKFDGQYYRVEDGEQSLFLIPTAEVVLNGFH
SQEILNEQDLPLYYAAFTPCFRREAGAGGSHERGLVRVHQFHKVEMFAFTTPEQEEIAYQKMIGIVEEILSELQLPYQLS
LLSTGDMSFTAKKTIDAEVWLPGQQAFYEVSSISKCGDFQSRRSETRYRDAQGKLHFVNTLNGSGLATPRLLVAILENYQ
QEDGSVVIPHALRPYMNNQEILLPKTDR

Sequences:

>Translated_428_residues
MLDIRLIRKEPKECEARLQKKDPSISLERLLDLDKNVRQLKADSESLLARRKALSGQIHKAKVANEDATPLIQGVNAIAD
QLVAFEKTLQEQEALLLDLMARLPNYPDEDVPVSPDKSGNKIIKSHGEIPTFTFPPKHHVQLNEKLQILDFKLPAKTSGS
GWPAYKNEGVLLEWALLTYLLNKQQAHGFQLWLPPLLVKRDILFGSGQIPKFDGQYYRVEDGEQSLFLIPTAEVVLNGFH
SQEILNEQDLPLYYAAFTPCFRREAGAGGSHERGLVRVHQFHKVEMFAFTTPEQEEIAYQKMIGIVEEILSELQLPYQLS
LLSTGDMSFTAKKTIDAEVWLPGQQAFYEVSSISKCGDFQSRRSETRYRDAQGKLHFVNTLNGSGLATPRLLVAILENYQ
QEDGSVVIPHALRPYMNNQEILLPKTDR
>Mature_428_residues
MLDIRLIRKEPKECEARLQKKDPSISLERLLDLDKNVRQLKADSESLLARRKALSGQIHKAKVANEDATPLIQGVNAIAD
QLVAFEKTLQEQEALLLDLMARLPNYPDEDVPVSPDKSGNKIIKSHGEIPTFTFPPKHHVQLNEKLQILDFKLPAKTSGS
GWPAYKNEGVLLEWALLTYLLNKQQAHGFQLWLPPLLVKRDILFGSGQIPKFDGQYYRVEDGEQSLFLIPTAEVVLNGFH
SQEILNEQDLPLYYAAFTPCFRREAGAGGSHERGLVRVHQFHKVEMFAFTTPEQEEIAYQKMIGIVEEILSELQLPYQLS
LLSTGDMSFTAKKTIDAEVWLPGQQAFYEVSSISKCGDFQSRRSETRYRDAQGKLHFVNTLNGSGLATPRLLVAILENYQ
QEDGSVVIPHALRPYMNNQEILLPKTDR

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI8923421, Length=440, Percent_Identity=33.1818181818182, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI225579074, Length=442, Percent_Identity=32.579185520362, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI16306548, Length=322, Percent_Identity=32.9192546583851, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=40.0932400932401, Blast_Score=305, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI17539260, Length=479, Percent_Identity=29.0187891440501, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17542084, Length=395, Percent_Identity=29.873417721519, Blast_Score=135, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6321799, Length=406, Percent_Identity=31.7733990147783, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320226, Length=374, Percent_Identity=32.0855614973262, Blast_Score=195, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17737985, Length=267, Percent_Identity=38.2022471910112, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24581334, Length=353, Percent_Identity=30.028328611898, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_CHLMU (Q9PLJ7)

Other databases:

- EMBL:   AE002160
- PIR:   C81742
- RefSeq:   NP_296486.1
- ProteinModelPortal:   Q9PLJ7
- SMR:   Q9PLJ7
- GeneID:   1245632
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0102
- TIGR:   TC_0102
- HOGENOM:   HBG629391
- OMA:   FQARRIR
- PhylomeDB:   Q9PLJ7
- ProtClustDB:   PRK05431
- BioCyc:   CMUR243161:TC_0102-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48473; Mature: 48473

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 278-278 BINDING 285-285 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIRLIRKEPKECEARLQKKDPSISLERLLDLDKNVRQLKADSESLLARRKALSGQIHK
CCCEEEHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHH
AKVANEDATPLIQGVNAIADQLVAFEKTLQEQEALLLDLMARLPNYPDEDVPVSPDKSGN
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
KIIKSHGEIPTFTFPPKHHVQLNEKLQILDFKLPAKTSGSGWPAYKNEGVLLEWALLTYL
HHHHCCCCCCCEECCCCCCEEECCCEEEEEEECCCCCCCCCCCCCCCCCEEEHHHHHHHH
LNKQQAHGFQLWLPPLLVKRDILFGSGQIPKFDGQYYRVEDGEQSLFLIPTAEVVLNGFH
HHHHHCCCEEEECCHHHHHHHHEECCCCCCCCCCCEEEEECCCCCEEEEEHHHHHHCCCH
SQEILNEQDLPLYYAAFTPCFRREAGAGGSHERGLVRVHQFHKVEMFAFTTPEQEEIAYQ
HHHHCCCCCCCEEEEHHCHHHHHHCCCCCCCCCCHHEEHHHEEEEEEEECCCCHHHHHHH
KMIGIVEEILSELQLPYQLSLLSTGDMSFTAKKTIDAEVWLPGQQAFYEVSSISKCGDFQ
HHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCCCEEEECCHHHHHHHHHHHHHCCHH
SRRSETRYRDAQGKLHFVNTLNGSGLATPRLLVAILENYQQEDGSVVIPHALRPYMNNQE
HHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEECCHHHCCCCCCCE
ILLPKTDR
EEECCCCC
>Mature Secondary Structure
MLDIRLIRKEPKECEARLQKKDPSISLERLLDLDKNVRQLKADSESLLARRKALSGQIHK
CCCEEEHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHH
AKVANEDATPLIQGVNAIADQLVAFEKTLQEQEALLLDLMARLPNYPDEDVPVSPDKSGN
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
KIIKSHGEIPTFTFPPKHHVQLNEKLQILDFKLPAKTSGSGWPAYKNEGVLLEWALLTYL
HHHHCCCCCCCEECCCCCCEEECCCEEEEEEECCCCCCCCCCCCCCCCCEEEHHHHHHHH
LNKQQAHGFQLWLPPLLVKRDILFGSGQIPKFDGQYYRVEDGEQSLFLIPTAEVVLNGFH
HHHHHCCCEEEECCHHHHHHHHEECCCCCCCCCCCEEEEECCCCCEEEEEHHHHHHCCCH
SQEILNEQDLPLYYAAFTPCFRREAGAGGSHERGLVRVHQFHKVEMFAFTTPEQEEIAYQ
HHHHCCCCCCCEEEEHHCHHHHHHCCCCCCCCCCHHEEHHHEEEEEEEECCCCHHHHHHH
KMIGIVEEILSELQLPYQLSLLSTGDMSFTAKKTIDAEVWLPGQQAFYEVSSISKCGDFQ
HHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCCCEEEECCHHHHHHHHHHHHHCCHH
SRRSETRYRDAQGKLHFVNTLNGSGLATPRLLVAILENYQQEDGSVVIPHALRPYMNNQE
HHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEECCHHHCCCCCCCE
ILLPKTDR
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935