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Identifier: 15834725

GI number: 15834725

Start: 117718

End: 119697

Strand: Reverse

Name: Not Available

Synonym: TC0100

Alternate gene names: 15834725

Gene position: 119697-117718 (Counterclockwise)

Preceding gene: 15834726

Following gene: 15834724

Centisome position: 11.16

GC content: 43.33

Gene sequence:

>1980_bases
ATGCTCCCACAACTTTTCTCTTCTCCATTTTCACGGGAATTACTCAACGATTTTTTTGAATCAGGGATGGCAGAGGAAAA
CAGTCCTTTACTTTCCCGAAAGAATCGTCTTTTAAGCCAAAACTTAACCCTAAAATCTGCCTACATATCCCTTGCTCTTT
ATATAGGGTCGCTTCTTTCTCATTGGACCGGATATCAGCCTCTCTCTTCTTTGCTACTTATTCTTACTTTCTTCCTAGCT
GGAACGCCTGCCCTCGTAAAATCTTTTGAGGATATTCTTAATAAAACGGTGAATATCGATATTCTCATGACATCTGCAGC
TTTCGGCTCTATTTTCATTGGAGGAGCCTTAGAAGGCGCATTGCTTTTAGTACTTTTCGCTATTTCAGAATCTCTAGGAT
CGATGGTCTCAGGGAAAGCCAAAAGTACTCTCGCTTCTTTAAAACATTTGGCACCTACTGTAGCTTGGGTTGTTCAACAA
GATGGCTCATTACAAAAGATTTTAGTACAAAATGTAAAAGTCGGAGAGGTTATCCGAGTTAAGAGTGGAGAGGTTGTCCC
TTTAGATGGAGAAATTATCCAAGGAGCCTCCTCTATTAATCTGATGCATCTAACAGGAGAAAAGATTCCCAAATCTTGTA
ATATTGGGGATACGGTTCCCGCAGGAGCTCATAACTTAGAAGGAAGTTTTGACCTCAAAGTTCTTAGAATTGGAGCAGAG
TCCACCATTGCCCACATCATCAATCTTGTTATCCAAGCACAAAGCGCTAAACCTAAACTCCAGCAACGTTTAGATCGTTA
CTCATCAACGTATGCCTTAACAATCTTCGCGATCTCAGCCTCTATAGCAATAGGCGGTTCATTATTTACGACACTGCCTT
TCCTAGGGCCAGACAGTGCTTTTTACCGAGCCTTAGCCTTCTTAATTGCAGCTTCTCCTTGTGCCCTTATCATAGCTATC
CCTATTGCCTATCTCAGCACCATTAATGCCTGTGCCAAACATGGAGTTTTACTAAAGGGAGGCGTAGTCTTAGATCGCTT
AGTCTCTTGCAACTCCGTAGTGATGGATAAGACTGGGACACTGACTACCGGAGACTTAACCTGCTGTGGATGTGAAGATT
TTGGCCCTGAATCCCCTCTTTTTTACTCCTATGTGCTAGCAATGGAACAATCTTCGTCCCACCCCATTGCTCAGGCAATT
GTTAATTATCTAACAGAGAAACAAGTGCTTCCCCTACCGGCAACACAATGTACTACCATTCCAGGCGAGGGTGTACAAGG
AGAATTTAATGGAGATCAGGCCTTTGTTGGACGAGTCTCAACAGCCCTACGCTATGTCCCTGAAGAATATCGAGAACAAC
TTCGCGAACGTGCTCAACAAGCACAAGCGCGAGGAGAGACCTGTTCCATTGCTTGCTCTGGGCAACGCGTGTCTCTTTTT
TACTTTCGAGATGCCCCGCGCCATGATGCTGCAGATATTGTCGCCTATTTGAAAAAAAATGGTTATCCAGTATGCATGCT
CACAGGAGATCATCGTATTAGCGCAGAAAACACAGCTCAACTGCTTGGAATTGATGAAGTGTTCTACGATCTAACCCCAG
ATAATAAACTTTCTAAAATCCAAGAACTCGCAAAGACTCGACAAATCATGATGGTGGGAGATGGAATTAATGATGCCCCG
GCTCTAGCGCAAGCTACTGTAGGGATCGCTATGGGGGAAGCTGGCAGCGCAACAGCCATAGAAGCTGCTGATGTAGTTCT
CTTAAACCAAGGGCTCTCTTCTCTTCCCTGGCTGATAAAAAAAGCAAAAAAGACTCGCCGAATTGTGTCGCAAAATCTTG
CTTTGGCTTTATCTATTATTTTATTTATTTCAGGACCAGCATCTATGGGAATCATTCCTTTATGGCTTGCCGTAATTTTA
CATGAAGGAAGTACCGTGATTGTGGGCCTTAATGCTCTTCGCCTTTTAAAAAACACGTGA

Upstream 100 bases:

>100_bases
CCCCCGCAATTGTCTGGGGAGTAGGAATGTTTATTACTGCGATCAGCCTGTGCTGTTCTTTGATACGGTTATTCTAGTCT
AGACTCCTAGTAGGTATCCT

Downstream 100 bases:

>100_bases
TTTCCTTGTGATTTTTAGAGAAAGGAACGCATAACATCCCTTGTATGAAAAACACCAAATACTTACGCCAAGTGAACTTA
TGGATCTTTGTAGTGATCAT

Product: cation transporter E1-E2 family ATPase

Products: NA

Alternate protein names: Cadmium efflux ATPase [H]

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MLPQLFSSPFSRELLNDFFESGMAEENSPLLSRKNRLLSQNLTLKSAYISLALYIGSLLSHWTGYQPLSSLLLILTFFLA
GTPALVKSFEDILNKTVNIDILMTSAAFGSIFIGGALEGALLLVLFAISESLGSMVSGKAKSTLASLKHLAPTVAWVVQQ
DGSLQKILVQNVKVGEVIRVKSGEVVPLDGEIIQGASSINLMHLTGEKIPKSCNIGDTVPAGAHNLEGSFDLKVLRIGAE
STIAHIINLVIQAQSAKPKLQQRLDRYSSTYALTIFAISASIAIGGSLFTTLPFLGPDSAFYRALAFLIAASPCALIIAI
PIAYLSTINACAKHGVLLKGGVVLDRLVSCNSVVMDKTGTLTTGDLTCCGCEDFGPESPLFYSYVLAMEQSSSHPIAQAI
VNYLTEKQVLPLPATQCTTIPGEGVQGEFNGDQAFVGRVSTALRYVPEEYREQLRERAQQAQARGETCSIACSGQRVSLF
YFRDAPRHDAADIVAYLKKNGYPVCMLTGDHRISAENTAQLLGIDEVFYDLTPDNKLSKIQELAKTRQIMMVGDGINDAP
ALAQATVGIAMGEAGSATAIEAADVVLLNQGLSSLPWLIKKAKKTRRIVSQNLALALSIILFISGPASMGIIPLWLAVIL
HEGSTVIVGLNALRLLKNT

Sequences:

>Translated_659_residues
MLPQLFSSPFSRELLNDFFESGMAEENSPLLSRKNRLLSQNLTLKSAYISLALYIGSLLSHWTGYQPLSSLLLILTFFLA
GTPALVKSFEDILNKTVNIDILMTSAAFGSIFIGGALEGALLLVLFAISESLGSMVSGKAKSTLASLKHLAPTVAWVVQQ
DGSLQKILVQNVKVGEVIRVKSGEVVPLDGEIIQGASSINLMHLTGEKIPKSCNIGDTVPAGAHNLEGSFDLKVLRIGAE
STIAHIINLVIQAQSAKPKLQQRLDRYSSTYALTIFAISASIAIGGSLFTTLPFLGPDSAFYRALAFLIAASPCALIIAI
PIAYLSTINACAKHGVLLKGGVVLDRLVSCNSVVMDKTGTLTTGDLTCCGCEDFGPESPLFYSYVLAMEQSSSHPIAQAI
VNYLTEKQVLPLPATQCTTIPGEGVQGEFNGDQAFVGRVSTALRYVPEEYREQLRERAQQAQARGETCSIACSGQRVSLF
YFRDAPRHDAADIVAYLKKNGYPVCMLTGDHRISAENTAQLLGIDEVFYDLTPDNKLSKIQELAKTRQIMMVGDGINDAP
ALAQATVGIAMGEAGSATAIEAADVVLLNQGLSSLPWLIKKAKKTRRIVSQNLALALSIILFISGPASMGIIPLWLAVIL
HEGSTVIVGLNALRLLKNT
>Mature_659_residues
MLPQLFSSPFSRELLNDFFESGMAEENSPLLSRKNRLLSQNLTLKSAYISLALYIGSLLSHWTGYQPLSSLLLILTFFLA
GTPALVKSFEDILNKTVNIDILMTSAAFGSIFIGGALEGALLLVLFAISESLGSMVSGKAKSTLASLKHLAPTVAWVVQQ
DGSLQKILVQNVKVGEVIRVKSGEVVPLDGEIIQGASSINLMHLTGEKIPKSCNIGDTVPAGAHNLEGSFDLKVLRIGAE
STIAHIINLVIQAQSAKPKLQQRLDRYSSTYALTIFAISASIAIGGSLFTTLPFLGPDSAFYRALAFLIAASPCALIIAI
PIAYLSTINACAKHGVLLKGGVVLDRLVSCNSVVMDKTGTLTTGDLTCCGCEDFGPESPLFYSYVLAMEQSSSHPIAQAI
VNYLTEKQVLPLPATQCTTIPGEGVQGEFNGDQAFVGRVSTALRYVPEEYREQLRERAQQAQARGETCSIACSGQRVSLF
YFRDAPRHDAADIVAYLKKNGYPVCMLTGDHRISAENTAQLLGIDEVFYDLTPDNKLSKIQELAKTRQIMMVGDGINDAP
ALAQATVGIAMGEAGSATAIEAADVVLLNQGLSSLPWLIKKAKKTRRIVSQNLALALSIILFISGPASMGIIPLWLAVIL
HEGSTVIVGLNALRLLKNT

Specific function: This electroneutral antiporter ejects one cadmium ion while accumulating two protons by an energy-dependent efflux mechanism [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=641, Percent_Identity=29.4851794071763, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI115529486, Length=674, Percent_Identity=27.7448071216617, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI55743073, Length=545, Percent_Identity=29.7247706422018, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1789879, Length=644, Percent_Identity=31.6770186335404, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1786691, Length=555, Percent_Identity=33.8738738738739, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1786914, Length=533, Percent_Identity=27.3921200750469, Blast_Score=118, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17556548, Length=573, Percent_Identity=29.3193717277487, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71997262, Length=184, Percent_Identity=29.8913043478261, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997269, Length=187, Percent_Identity=29.9465240641711, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997275, Length=184, Percent_Identity=29.8913043478261, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17557486, Length=160, Percent_Identity=32.5, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17557770, Length=160, Percent_Identity=31.25, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI32566766, Length=160, Percent_Identity=31.25, Blast_Score=73, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320475, Length=545, Percent_Identity=29.5412844036697, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319772, Length=594, Percent_Identity=26.7676767676768, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6325221, Length=615, Percent_Identity=23.0894308943089, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321430, Length=619, Percent_Identity=22.2940226171244, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321271, Length=663, Percent_Identity=21.4177978883861, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221329854, Length=423, Percent_Identity=28.8416075650118, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24668704, Length=148, Percent_Identity=31.7567567567568, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281366617, Length=148, Percent_Identity=31.7567567567568, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24668708, Length=148, Percent_Identity=31.7567567567568, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161085803, Length=148, Percent_Identity=31.7567567567568, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24668696, Length=148, Percent_Identity=31.7567567567568, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17136664, Length=211, Percent_Identity=27.0142180094787, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24762455, Length=211, Percent_Identity=27.0142180094787, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24762453, Length=211, Percent_Identity=27.0142180094787, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24762447, Length=211, Percent_Identity=27.0142180094787, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24762457, Length=211, Percent_Identity=27.0142180094787, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24762449, Length=211, Percent_Identity=27.0142180094787, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24762445, Length=211, Percent_Identity=27.0142180094787, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24762451, Length=211, Percent_Identity=27.0142180094787, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3 [H]

Molecular weight: Translated: 70574; Mature: 70574

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPQLFSSPFSRELLNDFFESGMAEENSPLLSRKNRLLSQNLTLKSAYISLALYIGSLLS
CCCHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
HWTGYQPLSSLLLILTFFLAGTPALVKSFEDILNKTVNIDILMTSAAFGSIFIGGALEGA
HCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCEEECHHHHHH
LLLVLFAISESLGSMVSGKAKSTLASLKHLAPTVAWVVQQDGSLQKILVQNVKVGEVIRV
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHCCCCCCCEEEE
KSGEVVPLDGEIIQGASSINLMHLTGEKIPKSCNIGDTVPAGAHNLEGSFDLKVLRIGAE
CCCCEEECCHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCH
STIAHIINLVIQAQSAKPKLQQRLDRYSSTYALTIFAISASIAIGGSLFTTLPFLGPDSA
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEEEHHHHCCCHHHHHCCCCCCCHH
FYRALAFLIAASPCALIIAIPIAYLSTINACAKHGVLLKGGVVLDRLVSCNSVVMDKTGT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCCEEECCCCC
LTTGDLTCCGCEDFGPESPLFYSYVLAMEQSSSHPIAQAIVNYLTEKQVLPLPATQCTTI
EEECCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
PGEGVQGEFNGDQAFVGRVSTALRYVPEEYREQLRERAQQAQARGETCSIACSGQRVSLF
CCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEE
YFRDAPRHDAADIVAYLKKNGYPVCMLTGDHRISAENTAQLLGIDEVFYDLTPDNKLSKI
EECCCCCCCHHHHHHHHHCCCCEEEEEECCCEECCCCHHHHEEHHHHHHCCCCCHHHHHH
QELAKTRQIMMVGDGINDAPALAQATVGIAMGEAGSATAIEAADVVLLNQGLSSLPWLIK
HHHHHHCEEEEEECCCCCCHHHHHHHHHEEECCCCCCCEEHHHHHHEECCCHHHHHHHHH
KAKKTRRIVSQNLALALSIILFISGPASMGIIPLWLAVILHEGSTVIVGLNALRLLKNT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHCC
>Mature Secondary Structure
MLPQLFSSPFSRELLNDFFESGMAEENSPLLSRKNRLLSQNLTLKSAYISLALYIGSLLS
CCCHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
HWTGYQPLSSLLLILTFFLAGTPALVKSFEDILNKTVNIDILMTSAAFGSIFIGGALEGA
HCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCEEECHHHHHH
LLLVLFAISESLGSMVSGKAKSTLASLKHLAPTVAWVVQQDGSLQKILVQNVKVGEVIRV
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHCCCCCCCEEEE
KSGEVVPLDGEIIQGASSINLMHLTGEKIPKSCNIGDTVPAGAHNLEGSFDLKVLRIGAE
CCCCEEECCHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCH
STIAHIINLVIQAQSAKPKLQQRLDRYSSTYALTIFAISASIAIGGSLFTTLPFLGPDSA
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEEEHHHHCCCHHHHHCCCCCCCHH
FYRALAFLIAASPCALIIAIPIAYLSTINACAKHGVLLKGGVVLDRLVSCNSVVMDKTGT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCCEEECCCCC
LTTGDLTCCGCEDFGPESPLFYSYVLAMEQSSSHPIAQAIVNYLTEKQVLPLPATQCTTI
EEECCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
PGEGVQGEFNGDQAFVGRVSTALRYVPEEYREQLRERAQQAQARGETCSIACSGQRVSLF
CCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEE
YFRDAPRHDAADIVAYLKKNGYPVCMLTGDHRISAENTAQLLGIDEVFYDLTPDNKLSKI
EECCCCCCCHHHHHHHHHCCCCEEEEEECCCEECCCCHHHHEEHHHHHHCCCCCHHHHHH
QELAKTRQIMMVGDGINDAPALAQATVGIAMGEAGSATAIEAADVVLLNQGLSSLPWLIK
HHHHHHCEEEEEECCCCCCHHHHHHHHHEEECCCCCCCEEHHHHHHEECCCHHHHHHHHH
KAKKTRRIVSQNLALALSIILFISGPASMGIIPLWLAVILHEGSTVIVGLNALRLLKNT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188605; 8188606 [H]