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Identifier: 15834723

GI number: 15834723

Start: 115972

End: 116526

Strand: Direct

Name: Not Available

Synonym: TC0098

Alternate gene names: 15834723

Gene position: 115972-116526 (Clockwise)

Preceding gene: 15834722

Following gene: 15834728

Centisome position: 10.81

GC content: 40.72

Gene sequence:

>555_bases
ATGAAAGAGATCTATTATGAGATAGCGAGTACGGATTCAACAAATGCAACTGCTAAAAAAGGCATCTCTCTATGGGACCC
CTATGCCCTTACTGTAGTAACAACCAGAGAACAAACTGCTGGGAAAGGAAAGTTTGGTAGATATTGGCATTCCACGGATC
GAGATATCCTCGCTTCCTTTTGTTTCTTTTTGTGTGTAGATAGTGTGGATAGTGCTTTGTTGTTTCGTATAGGTACGGAA
GCAGTTATTCGTCTTGGAGCTTCTTTAGGCATTCCTGGAGCCGTTATGAAATGGCCTAATGATGTATTAGTTTTAGGGAA
AAAGCTTTCAGGAGTGCTATGTGAGACTGCCCCGGTAGATAAGGGATTATTTGTGATTATCGGCATAGGAGTCAATGGAA
ACGTATGTGCAGATGAATTGCTAGTTATAGATCAGCCAGCGACTTCTCTGCAGGAATTAATTGGGGAATCTTTAGATATG
GAAGAGCAAGTTTATCAACTTGCCAAGGAAATTAAATACCTCATACAAGAGCTTCCCTTATGGGGATCTAAGTAA

Upstream 100 bases:

>100_bases
TCCATAATCATCTAGTTGTTGGCTTGGCAGGGAAACTTTTCCGGTTTCCGAAAGTTCCGCTTTTGTCTTTAGCTGAAATG
ATTTAGAAAGGCTCGGTTGA

Downstream 100 bases:

>100_bases
GCTTGTATTAATATTTTGCAAAGCGTCGACTATAAATGCTTTGCAAGATACCTAGAGAGGCCATTGTAGAAATTACAGAA
GATCCTCCATAAGAAATTAG

Product: biotin--protein ligase

Products: NA

Alternate protein names: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase; Biotin--protein ligase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MKEIYYEIASTDSTNATAKKGISLWDPYALTVVTTREQTAGKGKFGRYWHSTDRDILASFCFFLCVDSVDSALLFRIGTE
AVIRLGASLGIPGAVMKWPNDVLVLGKKLSGVLCETAPVDKGLFVIIGIGVNGNVCADELLVIDQPATSLQELIGESLDM
EEQVYQLAKEIKYLIQELPLWGSK

Sequences:

>Translated_184_residues
MKEIYYEIASTDSTNATAKKGISLWDPYALTVVTTREQTAGKGKFGRYWHSTDRDILASFCFFLCVDSVDSALLFRIGTE
AVIRLGASLGIPGAVMKWPNDVLVLGKKLSGVLCETAPVDKGLFVIIGIGVNGNVCADELLVIDQPATSLQELIGESLDM
EEQVYQLAKEIKYLIQELPLWGSK
>Mature_184_residues
MKEIYYEIASTDSTNATAKKGISLWDPYALTVVTTREQTAGKGKFGRYWHSTDRDILASFCFFLCVDSVDSALLFRIGTE
AVIRLGASLGIPGAVMKWPNDVLVLGKKLSGVLCETAPVDKGLFVIIGIGVNGNVCADELLVIDQPATSLQELIGESLDM
EEQVYQLAKEIKYLIQELPLWGSK

Specific function: BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. This protein also activates biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting protein

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 20136; Mature: 20136

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIYYEIASTDSTNATAKKGISLWDPYALTVVTTREQTAGKGKFGRYWHSTDRDILASF
CCCEEEEEECCCCCCCHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHH
CFFLCVDSVDSALLFRIGTEAVIRLGASLGIPGAVMKWPNDVLVLGKKLSGVLCETAPVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEECCHHCCEEECCCCCC
KGLFVIIGIGVNGNVCADELLVIDQPATSLQELIGESLDMEEQVYQLAKEIKYLIQELPL
CCEEEEEEECCCCCCCCCCEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
WGSK
CCCC
>Mature Secondary Structure
MKEIYYEIASTDSTNATAKKGISLWDPYALTVVTTREQTAGKGKFGRYWHSTDRDILASF
CCCEEEEEECCCCCCCHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHH
CFFLCVDSVDSALLFRIGTEAVIRLGASLGIPGAVMKWPNDVLVLGKKLSGVLCETAPVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEECCHHCCEEECCCCCC
KGLFVIIGIGVNGNVCADELLVIDQPATSLQELIGESLDMEEQVYQLAKEIKYLIQELPL
CCEEEEEEECCCCCCCCCCEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
WGSK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7730294 [H]