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The map label for this gene is gpmA

Identifier: 15834720

GI number: 15834720

Start: 113634

End: 114314

Strand: Reverse

Name: gpmA

Synonym: TC0095

Alternate gene names: 15834720

Gene position: 114314-113634 (Counterclockwise)

Preceding gene: 15834724

Following gene: 15834719

Centisome position: 10.65

GC content: 39.35

Gene sequence:

>681_bases
ATGACTCTTCTTATTCTGCTACGCCACGGTCAATCCGTATGGAATCAAAAAAATCTATTTACTGGATGGGTAGATATCCC
TCTTAGTCAACAAGGAATTCAAGAAGCACTTACTGCTGGGGAAGCGATTAAAAATCTTCCTATTGATTGTATTTTTACCT
CTACTCTAGTCAGAAGCTTGATGACAGCTCTTCTAGCAATGACTAACCACAGCTCTAAAAAAATTCCTTATATTATTCAT
GAAGAACGCCCCGATATGAGTAGGATTCATAGTGAAAAAGAGTTGGAACAAATGATCCCCCTTTTTCAATCGAGCGCGCT
TAATGAGCGTATGTATGGAGAACTTCAGGGGAAAAATAAACAAGAAGTTGCAGAGCAATTTGGAGAAGAGCAGGTTAGAC
TCTGGCGTAGAAGCTACAAAATTGCTCCGCCACAAGGAGAAAGTCTCTTTGATACGGCGCAAAGAACTCTCCCTTACTTT
CAAAAGCGCATTTTTCCTCTTATCCAACAGGGAAAAAATATTTTTATTTCTGCTCATGGGAACTCTTTACGCTCTTTGAT
CATGGACCTAGAAAAATTAACTGAAGAAGAAGTACTCTCTTTAGAGTTGCCAACAGGGAAACCTATTGTATACGAATGGA
CGGAACAAAAATTCACGAAGAGCGCACTTTCGTTTGGTTAA

Upstream 100 bases:

>100_bases
TGCGCATCCCTACCTATAGACCTACAAGGTAAAAAAATCTTTGCAAAGATAATCCTTAAACGAGGAAGATAGGGCTTTCA
CAACAATCGTCCTGCTTTTT

Downstream 100 bases:

>100_bases
ATAATCAACAAACCATCCCGCCTTCTGAGATGGTTAAGGAAGCTTTTCAGCGTTATGCAAATGTGTTCTCCTGCGAAGTT
AATACTTCTGCTCTTGCTTT

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MTLLILLRHGQSVWNQKNLFTGWVDIPLSQQGIQEALTAGEAIKNLPIDCIFTSTLVRSLMTALLAMTNHSSKKIPYIIH
EERPDMSRIHSEKELEQMIPLFQSSALNERMYGELQGKNKQEVAEQFGEEQVRLWRRSYKIAPPQGESLFDTAQRTLPYF
QKRIFPLIQQGKNIFISAHGNSLRSLIMDLEKLTEEEVLSLELPTGKPIVYEWTEQKFTKSALSFG

Sequences:

>Translated_226_residues
MTLLILLRHGQSVWNQKNLFTGWVDIPLSQQGIQEALTAGEAIKNLPIDCIFTSTLVRSLMTALLAMTNHSSKKIPYIIH
EERPDMSRIHSEKELEQMIPLFQSSALNERMYGELQGKNKQEVAEQFGEEQVRLWRRSYKIAPPQGESLFDTAQRTLPYF
QKRIFPLIQQGKNIFISAHGNSLRSLIMDLEKLTEEEVLSLELPTGKPIVYEWTEQKFTKSALSFG
>Mature_225_residues
TLLILLRHGQSVWNQKNLFTGWVDIPLSQQGIQEALTAGEAIKNLPIDCIFTSTLVRSLMTALLAMTNHSSKKIPYIIHE
ERPDMSRIHSEKELEQMIPLFQSSALNERMYGELQGKNKQEVAEQFGEEQVRLWRRSYKIAPPQGESLFDTAQRTLPYFQ
KRIFPLIQQGKNIFISAHGNSLRSLIMDLEKLTEEEVLSLELPTGKPIVYEWTEQKFTKSALSFG

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI4502445, Length=243, Percent_Identity=37.4485596707819, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI40353764, Length=243, Percent_Identity=37.4485596707819, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI50593010, Length=240, Percent_Identity=36.6666666666667, Blast_Score=158, Evalue=4e-39,
Organism=Homo sapiens, GI4505753, Length=242, Percent_Identity=37.603305785124, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI71274132, Length=242, Percent_Identity=35.5371900826446, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI310129614, Length=193, Percent_Identity=33.160621761658, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1786970, Length=244, Percent_Identity=36.8852459016393, Blast_Score=163, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6322697, Length=243, Percent_Identity=38.2716049382716, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320183, Length=268, Percent_Identity=27.2388059701493, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324516, Length=268, Percent_Identity=25, Blast_Score=95, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24646216, Length=242, Percent_Identity=38.4297520661157, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI85725270, Length=245, Percent_Identity=37.9591836734694, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI85725272, Length=245, Percent_Identity=37.9591836734694, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24650981, Length=245, Percent_Identity=37.9591836734694, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI28571815, Length=239, Percent_Identity=29.7071129707113, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28571817, Length=239, Percent_Identity=29.7071129707113, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24648979, Length=239, Percent_Identity=29.7071129707113, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_CHLMU (Q9PLK4)

Other databases:

- EMBL:   AE002160
- PIR:   D81741
- RefSeq:   NP_296479.1
- ProteinModelPortal:   Q9PLK4
- SMR:   Q9PLK4
- GeneID:   1245625
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0095
- TIGR:   TC_0095
- HOGENOM:   HBG658938
- OMA:   IRTLWFV
- PhylomeDB:   Q9PLK4
- ProtClustDB:   PRK01112
- BioCyc:   CMUR243161:TC_0095-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 25964; Mature: 25833

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLILLRHGQSVWNQKNLFTGWVDIPLSQQGIQEALTAGEAIKNLPIDCIFTSTLVRSL
CEEEEEEECCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
MTALLAMTNHSSKKIPYIIHEERPDMSRIHSEKELEQMIPLFQSSALNERMYGELQGKNK
HHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QEVAEQFGEEQVRLWRRSYKIAPPQGESLFDTAQRTLPYFQKRIFPLIQQGKNIFISAHG
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
NSLRSLIMDLEKLTEEEVLSLELPTGKPIVYEWTEQKFTKSALSFG
HHHHHHHHHHHHHCHHHHEEEECCCCCCEEEECHHHHHHHHHHCCC
>Mature Secondary Structure 
TLLILLRHGQSVWNQKNLFTGWVDIPLSQQGIQEALTAGEAIKNLPIDCIFTSTLVRSL
EEEEEEECCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
MTALLAMTNHSSKKIPYIIHEERPDMSRIHSEKELEQMIPLFQSSALNERMYGELQGKNK
HHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
QEVAEQFGEEQVRLWRRSYKIAPPQGESLFDTAQRTLPYFQKRIFPLIQQGKNIFISAHG
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
NSLRSLIMDLEKLTEEEVLSLELPTGKPIVYEWTEQKFTKSALSFG
HHHHHHHHHHHHHCHHHHEEEECCCCCCEEEECHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935