Click here to switch to the map view.

The map label for this gene is gpsA

Identifier: 15834712

GI number: 15834712

Start: 105847

End: 106851

Strand: Reverse

Name: gpsA

Synonym: TC0087

Alternate gene names: 15834712

Gene position: 106851-105847 (Counterclockwise)

Preceding gene: 15834713

Following gene: 15834711

Centisome position: 9.96

GC content: 43.38

Gene sequence:

>1005_bases
ATGAAAGAGACTATAGCCTACCTTGGAATGGGCATGTGGGGATTTTCTTTAGCCAACCTTTTGGCTAACAATGGACATCG
CGTAGTGGGATGGGCAAGGAATCCTTCTTTGATTGAACAGCTATCTACTCAACGCCAGCACCCCGCAGCTCCTCATGTTA
CTATCCCTTCAAACCTTTCTTTCACATCCAGTATGGAAGAAGCTTTAGATGGGGCGACCATGATCGTTGAAGGAGTCACT
TCTGCAGGAATGAGACCAGTTCTCAATCAGCTCAAATCTATCACAGATTTGCAGATTCCTTTAGTCATTACATCAAAAGG
CATTGAGCAAAATACAGGATTGCTTCTAAGCGAAATTGCTTTAGAAATTTTTGGGAAACCAGCCGCGAAATATTTGGGAT
ATCTCAGCGGTCCATCTATTGCTAGCGAAGTTCTTCGTGGTTGTCCATGCTCTGTTGTCATTAGTGCGTATGATCCTGCT
ACCCTAAAACAAATCCACCAAGCTTTTCTTACTCCTACGTTCCGGGTCTATCCCAATAGTGACCTTAAAGGGGTTGCTTT
AGGCGGAGCATTAAAAAATGTCATTGCTATTGCCTGTGGAATTTCTGATGGATTCCGGTTCGGAGACAATGCTAAATCTG
GACTCGTGACTCGCGGGCTACATGAGATCCGCAAATTTGCCACGATTATGGGATGTCGTCCAGATACCTTGAATGGACTT
GCAGGTCTAGGAGATCTCTGTACCACTTGCTTTTCCGCTTTCAGCAGAAACACCCTTTTTGGAAAAATGCTTGCTGAAGG
CTTAACCCCTGAACAGGCAAAAACAAAAATTGGCATGGTGGTTGAAGGAGTTTACACAGCTCTATCCGCTCATCAAATTG
CCACACATCACAAGATAGACATGCCCATCACTACTGGTGTCTATCGTGTTCTTTATGAAAATCTAGATATTCAAAAGGGA
ATTGCCCAGCTTCTTCAACGGAATACAAAAGAAGAATATTTATAA

Upstream 100 bases:

>100_bases
CAATATTTGAATTAGAAGCGGACTTTTATTACCCTTCCTCCCATACTTCCTTAGAGTGGGAAAACAAAATATTTTTCCAG
GAACCAATTATTGAGGCCTC

Downstream 100 bases:

>100_bases
GGCTTTTCCTTCAAAGAAAAAATCTCTGAAAAGCTTTGTCCCGTTGGTGGACGAAGTTTTTCCTTTGTACAATTTTTTGG
CATTTGCTAAAGATACGGAT

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKETIAYLGMGMWGFSLANLLANNGHRVVGWARNPSLIEQLSTQRQHPAAPHVTIPSNLSFTSSMEEALDGATMIVEGVT
SAGMRPVLNQLKSITDLQIPLVITSKGIEQNTGLLLSEIALEIFGKPAAKYLGYLSGPSIASEVLRGCPCSVVISAYDPA
TLKQIHQAFLTPTFRVYPNSDLKGVALGGALKNVIAIACGISDGFRFGDNAKSGLVTRGLHEIRKFATIMGCRPDTLNGL
AGLGDLCTTCFSAFSRNTLFGKMLAEGLTPEQAKTKIGMVVEGVYTALSAHQIATHHKIDMPITTGVYRVLYENLDIQKG
IAQLLQRNTKEEYL

Sequences:

>Translated_334_residues
MKETIAYLGMGMWGFSLANLLANNGHRVVGWARNPSLIEQLSTQRQHPAAPHVTIPSNLSFTSSMEEALDGATMIVEGVT
SAGMRPVLNQLKSITDLQIPLVITSKGIEQNTGLLLSEIALEIFGKPAAKYLGYLSGPSIASEVLRGCPCSVVISAYDPA
TLKQIHQAFLTPTFRVYPNSDLKGVALGGALKNVIAIACGISDGFRFGDNAKSGLVTRGLHEIRKFATIMGCRPDTLNGL
AGLGDLCTTCFSAFSRNTLFGKMLAEGLTPEQAKTKIGMVVEGVYTALSAHQIATHHKIDMPITTGVYRVLYENLDIQKG
IAQLLQRNTKEEYL
>Mature_334_residues
MKETIAYLGMGMWGFSLANLLANNGHRVVGWARNPSLIEQLSTQRQHPAAPHVTIPSNLSFTSSMEEALDGATMIVEGVT
SAGMRPVLNQLKSITDLQIPLVITSKGIEQNTGLLLSEIALEIFGKPAAKYLGYLSGPSIASEVLRGCPCSVVISAYDPA
TLKQIHQAFLTPTFRVYPNSDLKGVALGGALKNVIAIACGISDGFRFGDNAKSGLVTRGLHEIRKFATIMGCRPDTLNGL
AGLGDLCTTCFSAFSRNTLFGKMLAEGLTPEQAKTKIGMVVEGVYTALSAHQIATHHKIDMPITTGVYRVLYENLDIQKG
IAQLLQRNTKEEYL

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=334, Percent_Identity=28.4431137724551, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI24307999, Length=344, Percent_Identity=25.8720930232558, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1790037, Length=331, Percent_Identity=38.6706948640483, Blast_Score=216, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17507425, Length=341, Percent_Identity=26.3929618768328, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32564399, Length=332, Percent_Identity=25.3012048192771, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI193210136, Length=341, Percent_Identity=25.2199413489736, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI32564403, Length=341, Percent_Identity=25.2199413489736, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI193210134, Length=212, Percent_Identity=29.7169811320755, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320181, Length=344, Percent_Identity=26.453488372093, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324513, Length=350, Percent_Identity=24.2857142857143, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI22026922, Length=290, Percent_Identity=24.8275862068966, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17136204, Length=336, Percent_Identity=23.2142857142857, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136202, Length=336, Percent_Identity=23.2142857142857, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136200, Length=336, Percent_Identity=23.2142857142857, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648969, Length=252, Percent_Identity=25.7936507936508, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_CHLMU (Q9PLL2)

Other databases:

- EMBL:   AE002160
- PIR:   A81743
- RefSeq:   NP_296471.1
- ProteinModelPortal:   Q9PLL2
- SMR:   Q9PLL2
- GeneID:   1245617
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0087
- TIGR:   TC_0087
- HOGENOM:   HBG586392
- OMA:   SQTLRGN
- PhylomeDB:   Q9PLL2
- ProtClustDB:   PRK00094
- BioCyc:   CMUR243161:TC_0087-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 35938; Mature: 35938

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 192-192 BINDING 106-106 BINDING 106-106 BINDING 141-141 BINDING 256-256 BINDING 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETIAYLGMGMWGFSLANLLANNGHRVVGWARNPSLIEQLSTQRQHPAAPHVTIPSNLS
CCCHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCCEEECCCCCC
FTSSMEEALDGATMIVEGVTSAGMRPVLNQLKSITDLQIPLVITSKGIEQNTGLLLSEIA
HHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHH
LEIFGKPAAKYLGYLSGPSIASEVLRGCPCSVVISAYDPATLKQIHQAFLTPTFRVYPNS
HHHHCCCHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEECCCC
DLKGVALGGALKNVIAIACGISDGFRFGDNAKSGLVTRGLHEIRKFATIMGCRPDTLNGL
CCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
AGLGDLCTTCFSAFSRNTLFGKMLAEGLTPEQAKTKIGMVVEGVYTALSAHQIATHHKID
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MPITTGVYRVLYENLDIQKGIAQLLQRNTKEEYL
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MKETIAYLGMGMWGFSLANLLANNGHRVVGWARNPSLIEQLSTQRQHPAAPHVTIPSNLS
CCCHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCCEEECCCCCC
FTSSMEEALDGATMIVEGVTSAGMRPVLNQLKSITDLQIPLVITSKGIEQNTGLLLSEIA
HHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHH
LEIFGKPAAKYLGYLSGPSIASEVLRGCPCSVVISAYDPATLKQIHQAFLTPTFRVYPNS
HHHHCCCHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEECCCC
DLKGVALGGALKNVIAIACGISDGFRFGDNAKSGLVTRGLHEIRKFATIMGCRPDTLNGL
CCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
AGLGDLCTTCFSAFSRNTLFGKMLAEGLTPEQAKTKIGMVVEGVYTALSAHQIATHHKID
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MPITTGVYRVLYENLDIQKGIAQLLQRNTKEEYL
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935