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Identifier: 15834638

GI number: 15834638

Start: 19985

End: 20989

Strand: Reverse

Name: Not Available

Synonym: TC0013

Alternate gene names: 15834638

Gene position: 20989-19985 (Counterclockwise)

Preceding gene: 15834639

Following gene: 15834636

Centisome position: 1.96

GC content: 44.08

Gene sequence:

>1005_bases
ATGGCTTCTCCAGTATTTATAAAAAACCTTCCCCTTAGGTCCCAGATAGTTTACGCCCCTCTTGCAGGATTTTCTGATTA
CCCCTATCGCCGTATGTCGGCCCTATATCACCCTGCATTGATGTTCTGCGAAATGATCAAAATGGAAGGTCTGCACTACT
GTCCTAAACGTACGTTGCGCTTGTTAGATTTCTCAGAATCTATGCGCCCTATCGGAGGCCAGCTCTGCGGTAGCCGACCT
GATCTTGCAGGAGAATCTGCAAAAATTTTAGAGGGATTAGGCTTCGATCTCATCGATTTGAATTGTGGATGTCCTACAGA
TCGCATCACCAAAGATGGAAGTGGCTCTGGGATGCTCAAAACCCCTCAATTAATCGGGAAAGTAGTTGAGAGTATTGTAG
AAGCTGTTTCTGTTCCTGTAACAGTAAAAATCCGTTCTGGATGGGATTTCGAACACATCAATGTCGAAGAAACCGTTCAT
ATTATTAAAGAAAGCGGCGCAAGCGCTGTCTTTGTACATGGAAGAACTCGCTCTCAAGGATATCAAGGCCCCAGCAATTT
GGAGTTTATTGCACGAGCAAAGCGAGCTGCTGGAGAGCACTTTCCAGTATTTGGAAATGGAGATGTCTTTTCTCCTGAAG
CAGCTAAAACAATGTTAGAAACTACTCACTGTGATGGAGTCCTTGTCGCTCGCGGTACAATGGGAGCTCCTTGGATTGGA
AAACAAATAGAAGATTACTTAACCACAGGGACCTATTCTTCCCCATCCTTCTCCATGAGAAAGCAAGCGTTTGTACAGCA
CCTACAGTGGATAGAAGAATACTACCAAAGCGAAGAAAAGCTCTTAACAGATACCCGCAAACTGTGTGGTCACTACTTAA
TTCTTTCCCCAAGAGTTCGTTCTTTACGCGCTAGCCTAGCTAAAGCTTCCTCATCACAAGAAGTTTATCAGCTTATAAAC
GATTTTGAAGAATCTGCAGAAGGAGAAGAATCCTCTCCTGAATAG

Upstream 100 bases:

>100_bases
TTGACATTAGCCCAATGATCGCTCTCCTTTGTCTCGGGACTATTCCTTTCGTGATTCTAAAAATTGTGCGGTTCATTGTT
CTAAATATTTTTCAATCACC

Downstream 100 bases:

>100_bases
AAGAGGATGTCTTTCTAAAAAAATTCTTACTCTTGCTTCGTTAAATGCGCTTGTATTTTTTTAGATAGTGCGAACATATC
AATCGGATCATCACCGATTA

Product: NifR3/Smm1 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MASPVFIKNLPLRSQIVYAPLAGFSDYPYRRMSALYHPALMFCEMIKMEGLHYCPKRTLRLLDFSESMRPIGGQLCGSRP
DLAGESAKILEGLGFDLIDLNCGCPTDRITKDGSGSGMLKTPQLIGKVVESIVEAVSVPVTVKIRSGWDFEHINVEETVH
IIKESGASAVFVHGRTRSQGYQGPSNLEFIARAKRAAGEHFPVFGNGDVFSPEAAKTMLETTHCDGVLVARGTMGAPWIG
KQIEDYLTTGTYSSPSFSMRKQAFVQHLQWIEEYYQSEEKLLTDTRKLCGHYLILSPRVRSLRASLAKASSSQEVYQLIN
DFEESAEGEESSPE

Sequences:

>Translated_334_residues
MASPVFIKNLPLRSQIVYAPLAGFSDYPYRRMSALYHPALMFCEMIKMEGLHYCPKRTLRLLDFSESMRPIGGQLCGSRP
DLAGESAKILEGLGFDLIDLNCGCPTDRITKDGSGSGMLKTPQLIGKVVESIVEAVSVPVTVKIRSGWDFEHINVEETVH
IIKESGASAVFVHGRTRSQGYQGPSNLEFIARAKRAAGEHFPVFGNGDVFSPEAAKTMLETTHCDGVLVARGTMGAPWIG
KQIEDYLTTGTYSSPSFSMRKQAFVQHLQWIEEYYQSEEKLLTDTRKLCGHYLILSPRVRSLRASLAKASSSQEVYQLIN
DFEESAEGEESSPE
>Mature_333_residues
ASPVFIKNLPLRSQIVYAPLAGFSDYPYRRMSALYHPALMFCEMIKMEGLHYCPKRTLRLLDFSESMRPIGGQLCGSRPD
LAGESAKILEGLGFDLIDLNCGCPTDRITKDGSGSGMLKTPQLIGKVVESIVEAVSVPVTVKIRSGWDFEHINVEETVHI
IKESGASAVFVHGRTRSQGYQGPSNLEFIARAKRAAGEHFPVFGNGDVFSPEAAKTMLETTHCDGVLVARGTMGAPWIGK
QIEDYLTTGTYSSPSFSMRKQAFVQHLQWIEEYYQSEEKLLTDTRKLCGHYLILSPRVRSLRASLAKASSSQEVYQLIND
FEESAEGEESSPE

Specific function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs [H]

COG id: COG0042

COG function: function code J; tRNA-dihydrouridine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dus family [H]

Homologues:

Organism=Homo sapiens, GI239788462, Length=244, Percent_Identity=29.5081967213115, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI239788483, Length=238, Percent_Identity=29.4117647058824, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI31742496, Length=274, Percent_Identity=25.5474452554745, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI8923374, Length=245, Percent_Identity=26.530612244898, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI40807366, Length=228, Percent_Identity=25.8771929824561, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1789660, Length=267, Percent_Identity=31.8352059925094, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI1788462, Length=166, Percent_Identity=33.7349397590361, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI145693211, Length=233, Percent_Identity=29.6137339055794, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17543114, Length=286, Percent_Identity=26.5734265734266, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI25144369, Length=261, Percent_Identity=25.6704980842912, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17507177, Length=313, Percent_Identity=23.0031948881789, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323560, Length=332, Percent_Identity=25.9036144578313, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323433, Length=311, Percent_Identity=24.4372990353698, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323437, Length=235, Percent_Identity=23.8297872340426, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585320, Length=284, Percent_Identity=29.2253521126761, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19921524, Length=230, Percent_Identity=26.9565217391304, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24580595, Length=229, Percent_Identity=26.6375545851528, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19920448, Length=229, Percent_Identity=26.6375545851528, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004652
- InterPro:   IPR001269
- InterPro:   IPR018517 [H]

Pfam domain/function: PF01207 Dus [H]

EC number: NA

Molecular weight: Translated: 36999; Mature: 36867

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS01136 UPF0034

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPVFIKNLPLRSQIVYAPLAGFSDYPYRRMSALYHPALMFCEMIKMEGLHYCPKRTLR
CCCCCEEECCCCCHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LLDFSESMRPIGGQLCGSRPDLAGESAKILEGLGFDLIDLNCGCPTDRITKDGSGSGMLK
HHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCEE
TPQLIGKVVESIVEAVSVPVTVKIRSGWDFEHINVEETVHIIKESGASAVFVHGRTRSQG
CHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCHHHHHHHHHHCCCCEEEEECCCCCCC
YQGPSNLEFIARAKRAAGEHFPVFGNGDVFSPEAAKTMLETTHCDGVLVARGTMGAPWIG
CCCCCCHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCHH
KQIEDYLTTGTYSSPSFSMRKQAFVQHLQWIEEYYQSEEKLLTDTRKLCGHYLILSPRVR
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHH
SLRASLAKASSSQEVYQLINDFEESAEGEESSPE
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ASPVFIKNLPLRSQIVYAPLAGFSDYPYRRMSALYHPALMFCEMIKMEGLHYCPKRTLR
CCCCEEECCCCCHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LLDFSESMRPIGGQLCGSRPDLAGESAKILEGLGFDLIDLNCGCPTDRITKDGSGSGMLK
HHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCEE
TPQLIGKVVESIVEAVSVPVTVKIRSGWDFEHINVEETVHIIKESGASAVFVHGRTRSQG
CHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCHHHHHHHHHHCCCCEEEEECCCCCCC
YQGPSNLEFIARAKRAAGEHFPVFGNGDVFSPEAAKTMLETTHCDGVLVARGTMGAPWIG
CCCCCCHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCHH
KQIEDYLTTGTYSSPSFSMRKQAFVQHLQWIEEYYQSEEKLLTDTRKLCGHYLILSPRVR
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHH
SLRASLAKASSSQEVYQLINDFEESAEGEESSPE
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]