| Definition | Chlamydia muridarum Nigg, complete genome. |
|---|---|
| Accession | NC_002620 |
| Length | 1,072,950 |
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The map label for this gene is topA
Identifier: 15834637
GI number: 15834637
Start: 17361
End: 19958
Strand: Direct
Name: topA
Synonym: TC0012
Alternate gene names: 15834637
Gene position: 17361-19958 (Clockwise)
Preceding gene: 15834634
Following gene: 15834640
Centisome position: 1.62
GC content: 39.8
Gene sequence:
>2598_bases ATGAAAAAATCCTTAATCATCGTTGAGTCCCCAGCTAAGATCAAAACCTTACGAAAATTGTTAGGAGAAGGGTTTATTTT CGACTCTTCTTTGGGTCATATTGTAGATCTTCCAGCAAAAGGGTTTGGTATTGATATCGAAAAAGGATTTATTCCGGACT ACCAAATTCTAGAGGGGAAGGAAGAGGTTATTCGGAAAATTTGTGCTGAAGCCAAGAAATGCGACGTTGTTTATCTTGCT CCCGATCCAGACCGAGAGGGGGAGGCTATAGCATGGCATATTGCCAATCAGTTGCCTAAGAATACCAAAATTCAGAGAAT TTCTTTTAATGCGATCACTAAAGGGGCTGTTACAGAAGCGTTGAAGCATCCCCGAGAAATTGATATGGCGTTGGTTAATG CTCAGCAGGCGAGACGTTTTTTAGATCGCATAGTGGGGTATAAAATTTCTCCAATCTTGGGTCGCAAGTTGCAGCGATGG TCGGGAGTATCTGCAGGAAGAGTGCAGTCTGTAGCTTTGAAATTAGTTGTAGATCGAGAATACGCCATAGAACAATTTGT TCCTGTAGAGTTTTGGAATATTCGCGTTAATCTCCAAGATCCTAAAAGTCAGAAAACGTTTTGGGCGCATTTACATTCTG TAAATGGAAAAAAATGGGAAAAAGAAATTCCAGAGGGGAAGTCTTCTGAAGACGTAGTCTTAATTGATTCTAAAGAAAAA GCGGATGATTTAGTTTCCCTATTAGAATCAGCAACTTATTGCGTAGATCGCGTTGAATCTAAAGAGAAAAAGCGCAACGC ATATCCTCCATTTATTACTTCTACGTTACAGCAGGAAGCCAGTCGACATTATCGTTTTTCTTCCTCTAGAACGATGAATA TCGCTCAAACTTTATACGAAGGGGTGGATTTAGATAGTCAAGGCGCTGTGGGATTAATTACTTACATGAGAACCGATTCC GTTCGGACAGATCCTGAAGCTATCAAACAGGTGCGTAAGTATATAGAGAACCATTTTGGAAAAGAATATGTGCCTTCTTC TCCAAATATGTATGCCACGAAGAAAATGGCTCAGGATGCTCATGAGGCTATACGTCCTACAGATGTTTCTCTTTCTCCCG AATCCATACGTACAAAGTTAACAGAAGATCAGTACAAACTTTACTCTTTGATATGGAAGCGTTTTGTAGCTTCACAAATG ATTGCGGCCATCTATGATACTCTTGCCATTCAAATAGCGACAAATAAAGGCATAGATCTCCGGGCTACAGGTTCTTGCTT AAAGTTTAAGGGGTTTTTAGCTGTCTATGAAGAGAAAAGAGATGAAGAAGGAGATGAGGATGAGAATATTCAGCTTCCTA AGCTCCATGAGCGTGATGAGCTAAAAAAAGAGGAAATAGAAGCTGAACAATCGCATACTAAACCTCTACCGCGTTTCACA GAGGCCTCTTTAGTTAAGGAATTAGAAAAATCTGGCATAGGAAGACCTTCTACTTATGCTACGATTATGAATAAAATTCA GAGTCGGGAATATACATTAAAAGAAGGCCAACGATTACGTCCTACCGAGCTTGGAAAGGTAGTTTGTCAATTTTTAGAGA CGAATTTCCCTCGGATTATGGACATTGGTTTTACGGCTAAAATGGAAGATGAGCTAGAGCTTATCGCTGATAATAAAAAG CCTTGGAAACAGCTGTTACAAGAATTTTGTGAATTATTCCTTCCTTTTGTAGTGACGGCTGAAAAAGAAGCTTTTATTCC TCGTATTGTCACAGAAATGGACTGTCCAAGATGTCATAAAGGGAAACTAGTAAAAATTTGGTCTAAAAATCGATACTTCT TTGGTTGTTCGGAATACCCTACCTGTGATTACAAAACTTCGGAAGAAGAGCTCACTTTCGATAAAAGCGAGTATGCAGAC GATACTCCTTGGGATGCTCCTTGCGCTCTTTGTGGGGGGCAAATGAAAGTGCGACATGGGAAGTTTGGAAGCTTTCTCGG GTGCGAGAATTACCCACAATGTCATTATATTGTGAATCTTTTTAAAAAAGGAGAAGCTGGCTCAGAGCCTGAAGAGATCG TATCATGTCCTGCAGAAGGCTGTACTGGTCATCTCGTTAAAAGAAGATCGCGGTTTAATAAAATGTTTTATTCCTGTTCA GAGTATCCTGCGTGCAGCGTTATTGGGAACTCTGTAGATGCAGTCATTGAAAAATATACAGGAACTCCTAAAACTCCTTA TGAGAAGAAGATAAAAGCTAAAAAAGCAACAGCTTCTAAAAAGGGAAAAGCAACAAAAGGAAAGGCTTCTACTACGAAAA CAAAGAAAAAATCTACTGTAACGACGAAAAACAGAAAGACTGCAACCTATACACCTTCTTCTGCTTTAGCTGCTGTTATT GGTCCTGACCCAATAGATGGTTTCCCCGAAGCTACGAAAAAAATCTGGGCGTATATCAAAGAGCAGGGATTGCAATCGCC GAATAACAAAAGAGTCATTGTCCCTGATAGCAAAATGAAGCATGTAATCGGTGATGATCCGATTGATATGTTCGCACTAT CTAAAAAAATACAAGCGCATTTAACGAAGCAAGAGTAA
Upstream 100 bases:
>100_bases TAAATGAAGAGGGACTAATATAATCGTATAAGAAAAAGGTTTTTTTTTTTTAAAAAGCTTTTGTGCGAGAGACCAGGATC CCGCTTGTTGGCATTGGTGT
Downstream 100 bases:
>100_bases GAATTTTTTTAGAAAGACATCCTCTTCTATTCAGGAGAGGATTCTTCTCCTTCTGCAGATTCTTCAAAATCGTTTATAAG CTGATAAACTTCTTGTGATG
Product: DNA topoisomerase I/SWI domain fusion protein
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 865; Mature: 865
Protein sequence:
>865_residues MKKSLIIVESPAKIKTLRKLLGEGFIFDSSLGHIVDLPAKGFGIDIEKGFIPDYQILEGKEEVIRKICAEAKKCDVVYLA PDPDREGEAIAWHIANQLPKNTKIQRISFNAITKGAVTEALKHPREIDMALVNAQQARRFLDRIVGYKISPILGRKLQRW SGVSAGRVQSVALKLVVDREYAIEQFVPVEFWNIRVNLQDPKSQKTFWAHLHSVNGKKWEKEIPEGKSSEDVVLIDSKEK ADDLVSLLESATYCVDRVESKEKKRNAYPPFITSTLQQEASRHYRFSSSRTMNIAQTLYEGVDLDSQGAVGLITYMRTDS VRTDPEAIKQVRKYIENHFGKEYVPSSPNMYATKKMAQDAHEAIRPTDVSLSPESIRTKLTEDQYKLYSLIWKRFVASQM IAAIYDTLAIQIATNKGIDLRATGSCLKFKGFLAVYEEKRDEEGDEDENIQLPKLHERDELKKEEIEAEQSHTKPLPRFT EASLVKELEKSGIGRPSTYATIMNKIQSREYTLKEGQRLRPTELGKVVCQFLETNFPRIMDIGFTAKMEDELELIADNKK PWKQLLQEFCELFLPFVVTAEKEAFIPRIVTEMDCPRCHKGKLVKIWSKNRYFFGCSEYPTCDYKTSEEELTFDKSEYAD DTPWDAPCALCGGQMKVRHGKFGSFLGCENYPQCHYIVNLFKKGEAGSEPEEIVSCPAEGCTGHLVKRRSRFNKMFYSCS EYPACSVIGNSVDAVIEKYTGTPKTPYEKKIKAKKATASKKGKATKGKASTTKTKKKSTVTTKNRKTATYTPSSALAAVI GPDPIDGFPEATKKIWAYIKEQGLQSPNNKRVIVPDSKMKHVIGDDPIDMFALSKKIQAHLTKQE
Sequences:
>Translated_865_residues MKKSLIIVESPAKIKTLRKLLGEGFIFDSSLGHIVDLPAKGFGIDIEKGFIPDYQILEGKEEVIRKICAEAKKCDVVYLA PDPDREGEAIAWHIANQLPKNTKIQRISFNAITKGAVTEALKHPREIDMALVNAQQARRFLDRIVGYKISPILGRKLQRW SGVSAGRVQSVALKLVVDREYAIEQFVPVEFWNIRVNLQDPKSQKTFWAHLHSVNGKKWEKEIPEGKSSEDVVLIDSKEK ADDLVSLLESATYCVDRVESKEKKRNAYPPFITSTLQQEASRHYRFSSSRTMNIAQTLYEGVDLDSQGAVGLITYMRTDS VRTDPEAIKQVRKYIENHFGKEYVPSSPNMYATKKMAQDAHEAIRPTDVSLSPESIRTKLTEDQYKLYSLIWKRFVASQM IAAIYDTLAIQIATNKGIDLRATGSCLKFKGFLAVYEEKRDEEGDEDENIQLPKLHERDELKKEEIEAEQSHTKPLPRFT EASLVKELEKSGIGRPSTYATIMNKIQSREYTLKEGQRLRPTELGKVVCQFLETNFPRIMDIGFTAKMEDELELIADNKK PWKQLLQEFCELFLPFVVTAEKEAFIPRIVTEMDCPRCHKGKLVKIWSKNRYFFGCSEYPTCDYKTSEEELTFDKSEYAD DTPWDAPCALCGGQMKVRHGKFGSFLGCENYPQCHYIVNLFKKGEAGSEPEEIVSCPAEGCTGHLVKRRSRFNKMFYSCS EYPACSVIGNSVDAVIEKYTGTPKTPYEKKIKAKKATASKKGKATKGKASTTKTKKKSTVTTKNRKTATYTPSSALAAVI GPDPIDGFPEATKKIWAYIKEQGLQSPNNKRVIVPDSKMKHVIGDDPIDMFALSKKIQAHLTKQE >Mature_865_residues MKKSLIIVESPAKIKTLRKLLGEGFIFDSSLGHIVDLPAKGFGIDIEKGFIPDYQILEGKEEVIRKICAEAKKCDVVYLA PDPDREGEAIAWHIANQLPKNTKIQRISFNAITKGAVTEALKHPREIDMALVNAQQARRFLDRIVGYKISPILGRKLQRW SGVSAGRVQSVALKLVVDREYAIEQFVPVEFWNIRVNLQDPKSQKTFWAHLHSVNGKKWEKEIPEGKSSEDVVLIDSKEK ADDLVSLLESATYCVDRVESKEKKRNAYPPFITSTLQQEASRHYRFSSSRTMNIAQTLYEGVDLDSQGAVGLITYMRTDS VRTDPEAIKQVRKYIENHFGKEYVPSSPNMYATKKMAQDAHEAIRPTDVSLSPESIRTKLTEDQYKLYSLIWKRFVASQM IAAIYDTLAIQIATNKGIDLRATGSCLKFKGFLAVYEEKRDEEGDEDENIQLPKLHERDELKKEEIEAEQSHTKPLPRFT EASLVKELEKSGIGRPSTYATIMNKIQSREYTLKEGQRLRPTELGKVVCQFLETNFPRIMDIGFTAKMEDELELIADNKK PWKQLLQEFCELFLPFVVTAEKEAFIPRIVTEMDCPRCHKGKLVKIWSKNRYFFGCSEYPTCDYKTSEEELTFDKSEYAD DTPWDAPCALCGGQMKVRHGKFGSFLGCENYPQCHYIVNLFKKGEAGSEPEEIVSCPAEGCTGHLVKRRSRFNKMFYSCS EYPACSVIGNSVDAVIEKYTGTPKTPYEKKIKAKKATASKKGKATKGKASTTKTKKKSTVTTKNRKTATYTPSSALAAVI GPDPIDGFPEATKKIWAYIKEQGLQSPNNKRVIVPDSKMKHVIGDDPIDMFALSKKIQAHLTKQE
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=596, Percent_Identity=24.3288590604027, Blast_Score=120, Evalue=6e-27, Organism=Homo sapiens, GI4507635, Length=536, Percent_Identity=22.5746268656716, Blast_Score=92, Evalue=3e-18, Organism=Escherichia coli, GI1787529, Length=779, Percent_Identity=38.6392811296534, Blast_Score=454, Evalue=1e-129, Organism=Escherichia coli, GI1788061, Length=566, Percent_Identity=26.1484098939929, Blast_Score=120, Evalue=4e-28, Organism=Escherichia coli, GI48994931, Length=177, Percent_Identity=35.5932203389831, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI32563869, Length=625, Percent_Identity=24, Blast_Score=109, Evalue=6e-24, Organism=Caenorhabditis elegans, GI17555378, Length=544, Percent_Identity=24.0808823529412, Blast_Score=104, Evalue=2e-22, Organism=Saccharomyces cerevisiae, GI6323263, Length=534, Percent_Identity=25.0936329588015, Blast_Score=105, Evalue=4e-23, Organism=Drosophila melanogaster, GI24585251, Length=739, Percent_Identity=24.4925575101488, Blast_Score=120, Evalue=5e-27,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 97934; Mature: 97934
Theoretical pI: Translated: 8.94; Mature: 8.94
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.1 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 3.8 %Cys+Met (Translated Protein) 2.1 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 3.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKSLIIVESPAKIKTLRKLLGEGFIFDSSLGHIVDLPAKGFGIDIEKGFIPDYQILEGK CCCCEEEEECCHHHHHHHHHHCCCCEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHCCH EEVIRKICAEAKKCDVVYLAPDPDREGEAIAWHIANQLPKNTKIQRISFNAITKGAVTEA HHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEEHHHCCCCCCEEEEECCHHHHHHHHHH LKHPREIDMALVNAQQARRFLDRIVGYKISPILGRKLQRWSGVSAGRVQSVALKLVVDRE HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHEEEEECCH YAIEQFVPVEFWNIRVNLQDPKSQKTFWAHLHSVNGKKWEKEIPEGKSSEDVVLIDSKEK HHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEEECCHH ADDLVSLLESATYCVDRVESKEKKRNAYPPFITSTLQQEASRHYRFSSSRTMNIAQTLYE HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHH GVDLDSQGAVGLITYMRTDSVRTDPEAIKQVRKYIENHFGKEYVPSSPNMYATKKMAQDA CCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH HEAIRPTDVSLSPESIRTKLTEDQYKLYSLIWKRFVASQMIAAIYDTLAIQIATNKGIDL HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEE RATGSCLKFKGFLAVYEEKRDEEGDEDENIQLPKLHERDELKKEEIEAEQSHTKPLPRFT EECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHH EASLVKELEKSGIGRPSTYATIMNKIQSREYTLKEGQRLRPTELGKVVCQFLETNFPRIM HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCEEE DIGFTAKMEDELELIADNKKPWKQLLQEFCELFLPFVVTAEKEAFIPRIVTEMDCPRCHK ECCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCCCCC GKLVKIWSKNRYFFGCSEYPTCDYKTSEEELTFDKSEYADDTPWDAPCALCGGQMKVRHG CCEEEEEECCEEEECCCCCCCCCCCCCCHHCCCCHHHCCCCCCCCCCHHHCCCCEEEECC KFGSFLGCENYPQCHYIVNLFKKGEAGSEPEEIVSCPAEGCTGHLVKRRSRFNKMFYSCS CCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC EYPACSVIGNSVDAVIEKYTGTPKTPYEKKIKAKKATASKKGKATKGKASTTKTKKKSTV CCCCHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCE TTKNRKTATYTPSSALAAVIGPDPIDGFPEATKKIWAYIKEQGLQSPNNKRVIVPDSKMK EECCCCEEEECCCHHEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHH HVIGDDPIDMFALSKKIQAHLTKQE HHCCCCCHHHHHHHHHHHHHCCCCC >Mature Secondary Structure MKKSLIIVESPAKIKTLRKLLGEGFIFDSSLGHIVDLPAKGFGIDIEKGFIPDYQILEGK CCCCEEEEECCHHHHHHHHHHCCCCEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHCCH EEVIRKICAEAKKCDVVYLAPDPDREGEAIAWHIANQLPKNTKIQRISFNAITKGAVTEA HHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEEHHHCCCCCCEEEEECCHHHHHHHHHH LKHPREIDMALVNAQQARRFLDRIVGYKISPILGRKLQRWSGVSAGRVQSVALKLVVDRE HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHEEEEECCH YAIEQFVPVEFWNIRVNLQDPKSQKTFWAHLHSVNGKKWEKEIPEGKSSEDVVLIDSKEK HHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEEECCHH ADDLVSLLESATYCVDRVESKEKKRNAYPPFITSTLQQEASRHYRFSSSRTMNIAQTLYE HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHH GVDLDSQGAVGLITYMRTDSVRTDPEAIKQVRKYIENHFGKEYVPSSPNMYATKKMAQDA CCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH HEAIRPTDVSLSPESIRTKLTEDQYKLYSLIWKRFVASQMIAAIYDTLAIQIATNKGIDL HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEE RATGSCLKFKGFLAVYEEKRDEEGDEDENIQLPKLHERDELKKEEIEAEQSHTKPLPRFT EECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHH EASLVKELEKSGIGRPSTYATIMNKIQSREYTLKEGQRLRPTELGKVVCQFLETNFPRIM HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCEEE DIGFTAKMEDELELIADNKKPWKQLLQEFCELFLPFVVTAEKEAFIPRIVTEMDCPRCHK ECCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCCCCC GKLVKIWSKNRYFFGCSEYPTCDYKTSEEELTFDKSEYADDTPWDAPCALCGGQMKVRHG CCEEEEEECCEEEECCCCCCCCCCCCCCHHCCCCHHHCCCCCCCCCCHHHCCCCEEEECC KFGSFLGCENYPQCHYIVNLFKKGEAGSEPEEIVSCPAEGCTGHLVKRRSRFNKMFYSCS CCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC EYPACSVIGNSVDAVIEKYTGTPKTPYEKKIKAKKATASKKGKATKGKASTTKTKKKSTV CCCCHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCE TTKNRKTATYTPSSALAAVIGPDPIDGFPEATKKIWAYIKEQGLQSPNNKRVIVPDSKMK EECCCCEEEECCCHHEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHH HVIGDDPIDMFALSKKIQAHLTKQE HHCCCCCHHHHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11058132 [H]