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Identifier: 15834629

GI number: 15834629

Start: 3266

End: 5410

Strand: Direct

Name: Not Available

Synonym: TC0004

Alternate gene names: 15834629

Gene position: 3266-5410 (Clockwise)

Preceding gene: 15834626

Following gene: 15834630

Centisome position: 0.3

GC content: 39.21

Gene sequence:

>2145_bases
ATGGATTATCTAGAAAAGCTACAGTCCTTAATGGAAAATCATCCTTCGGATTTTTTTAGTTTGTGGGAAGAGTATTGCTT
TAATGACGTCGTTAGTGGAGACGAGTTGATAGTCTTGCTGGAAAAAATTAAAAGCTCAAGTATAGCTCCTGCCTTTGGGA
AAATAGCAGAAAGCGTAATTCCTCTTTGGGAACAACTTCCTGAAAGTGAAGAAAAAGATAAAGTGCTTTCTCTAGTCTTT
GATATCCAAACAACAAACAGCAAGCGTTTATTAGAACTAGCTCTTCAACAGGTTAAGAAGTACGAGGACTCACCAAATTA
TAAAGAAGCTTTGCGGATAGTCGGATTAAGAGATGGGATTTTCTTTACTCATTGCTTAAGACATTTTGCTTTGCTTATGC
ATCTTTGTGAAGGGAACTTTGTTTTCCATCAGGGAGGATGGGGAGTAGGAGAGATTATGGGAGTTTCTTTCCTTCAGCAG
AAAGTCCTTGTTGAGTTTGAGGGAGTTCTTACAGCAAAAGATATTTCTTTTGAAACAGCCTTTCGCATGCTGTCTCCTCT
AAAAAAAGATCACTTTTTAGCAAGACGGTTTGGGGATCCCGATGCATTTGAGGCGTTTGCTAGAAAAGATCCTGTTGCGG
TCATAGAATGTCTGCTAAAAGACCTTGGACCCAAAAATGCTAAGGAAATCCGTAATGAGCTGGTTGGACTTGTGATTCCA
GAGGAGGATTGGAGTAGATGGTGGCAGTCCGCTAAGATTAAAATGAAGAAGGATTCACATATCCTGGCGCCTACTTCTTC
TAAAGATCCCTATATTTTTGATCCAAAAGGTTTTTCTTTCATTTCTCAATTACAAGCTTCTTTGTCGGGAAGCAACGATG
CTAGTAAAAAGATCGCTTCTTGTTACACATTTGTTAGAGATCTTGGGAGTGAGCTTAAGGATGAGGCTAATCGGCAGTTT
GTGATAAAAGAGTTAAAATCTTTAGATTTGCCAGCGGATTCCGCCTTATCCATTCAGAGAGCGATGTTATTATCTGAATT
CCTCGGAGATAAGTCTTCAGAATTAGATTGTGAAAACATTGCTAAGCTTTCCGAAGATCAAATGTTTGATATTGTCAACC
ATATTGAAATTCTATCTTTTCAGAAGAGTTTCCTATCGCTAATACACTCTTGCTCTCCAGCTTGGGTATCGGTATTTACA
AAAATTCTCCTGACAACAAGTACTTCTATTCTTCGCGATCAAGTCTTTAAAGCATTGATTGTAGATAAAAAGGCTAGAGA
AAGCATCTTAGAAAAAGTATCAGCTATGATTGAGCAACCCTTGCTTTATCCTGAGCTGTTTGTTTGGTTGTTTTTGCGAG
TAGTTTCTGGGGAAGACGGGCTGTTTTCTGAGTCGGATAGGAAGGAAATTGGAAGACAGATGCTAGCTAGTGCTTTAGAG
TTTATGCATAAAGTGGCTGGCTCTCCTCAAAAAGATCTTGGGAAAAAACTCTACTCATTCTTAGTCGGTCAACGATTTCT
TGCAATTCGTCAGATCATAGAAAATGCTTCTATAGATTATCTTAAAGAATTTGTTTTATTATCTTCAAAATGCCCTCAGT
TTACTCAAGGAGATCTTGGAGTTTTGAGAAGTTTAGCAGAAGTTGTGCAACCCGCTCTTAAACGAAGGGTTGCGGAAGAG
GAAAATATCCTTTGGACAACCTCTGAGAGTTTTACTCGAATGAAGGCAAAACTTCAGTCTCTTATTGGGAAGGAAATGGT
GGATAATGCCAAAGAGATAGAGGATGCAAGAGCTCTAGGAGACTTAAGAGAGAACTCTGAGTACAAATTTGCTTTGGAAA
GACGGGCTAGACTCCAGGAAGAAATTCGAGTATTGTCTGAGGAAATTAATCGCGCAAAAATTCTAACAAAAGATGCTGTG
TTTACAAATTCTGTTGGAGTTGGTTGCAAGGTTGTTCTTGAGGATGAGCAAGGGGAAGAGGATTGTTACACAATACTAGG
CCCTTGGGACGCCAATCCAGAGGAAAAGATTTTATCGTTAAAATCTAAACTTGCGCAAGAGATGGTTGGGAAGACAGTTG
GAGAGAGTGTGCTATTCCAAGGGAAGAAGCACAAGATAAAACAAATCTCTTCCATATGGGACTAA

Upstream 100 bases:

>100_bases
GTTTTATTTAATAATAAAATTTTTCTTGTTTTTTTTGTGACGTAATATTGCTCTTTTTTATTGTTCAGCGTATATTTCCG
GACTAAAAAGGGGAGCTATC

Downstream 100 bases:

>100_bases
AAGAATTTGGAGCATAGCGGGATCGAACCGCTGACCTCAACAATGCCATTGTTGCGCTCTACCAACTGAGCTAATACCCC
GAGAGAAGAGACTAGGGTAT

Product: transcript cleavage factor/unknown domain fusion protein

Products: NA

Alternate protein names: Transcript cleavage factor greA

Number of amino acids: Translated: 714; Mature: 714

Protein sequence:

>714_residues
MDYLEKLQSLMENHPSDFFSLWEEYCFNDVVSGDELIVLLEKIKSSSIAPAFGKIAESVIPLWEQLPESEEKDKVLSLVF
DIQTTNSKRLLELALQQVKKYEDSPNYKEALRIVGLRDGIFFTHCLRHFALLMHLCEGNFVFHQGGWGVGEIMGVSFLQQ
KVLVEFEGVLTAKDISFETAFRMLSPLKKDHFLARRFGDPDAFEAFARKDPVAVIECLLKDLGPKNAKEIRNELVGLVIP
EEDWSRWWQSAKIKMKKDSHILAPTSSKDPYIFDPKGFSFISQLQASLSGSNDASKKIASCYTFVRDLGSELKDEANRQF
VIKELKSLDLPADSALSIQRAMLLSEFLGDKSSELDCENIAKLSEDQMFDIVNHIEILSFQKSFLSLIHSCSPAWVSVFT
KILLTTSTSILRDQVFKALIVDKKARESILEKVSAMIEQPLLYPELFVWLFLRVVSGEDGLFSESDRKEIGRQMLASALE
FMHKVAGSPQKDLGKKLYSFLVGQRFLAIRQIIENASIDYLKEFVLLSSKCPQFTQGDLGVLRSLAEVVQPALKRRVAEE
ENILWTTSESFTRMKAKLQSLIGKEMVDNAKEIEDARALGDLRENSEYKFALERRARLQEEIRVLSEEINRAKILTKDAV
FTNSVGVGCKVVLEDEQGEEDCYTILGPWDANPEEKILSLKSKLAQEMVGKTVGESVLFQGKKHKIKQISSIWD

Sequences:

>Translated_714_residues
MDYLEKLQSLMENHPSDFFSLWEEYCFNDVVSGDELIVLLEKIKSSSIAPAFGKIAESVIPLWEQLPESEEKDKVLSLVF
DIQTTNSKRLLELALQQVKKYEDSPNYKEALRIVGLRDGIFFTHCLRHFALLMHLCEGNFVFHQGGWGVGEIMGVSFLQQ
KVLVEFEGVLTAKDISFETAFRMLSPLKKDHFLARRFGDPDAFEAFARKDPVAVIECLLKDLGPKNAKEIRNELVGLVIP
EEDWSRWWQSAKIKMKKDSHILAPTSSKDPYIFDPKGFSFISQLQASLSGSNDASKKIASCYTFVRDLGSELKDEANRQF
VIKELKSLDLPADSALSIQRAMLLSEFLGDKSSELDCENIAKLSEDQMFDIVNHIEILSFQKSFLSLIHSCSPAWVSVFT
KILLTTSTSILRDQVFKALIVDKKARESILEKVSAMIEQPLLYPELFVWLFLRVVSGEDGLFSESDRKEIGRQMLASALE
FMHKVAGSPQKDLGKKLYSFLVGQRFLAIRQIIENASIDYLKEFVLLSSKCPQFTQGDLGVLRSLAEVVQPALKRRVAEE
ENILWTTSESFTRMKAKLQSLIGKEMVDNAKEIEDARALGDLRENSEYKFALERRARLQEEIRVLSEEINRAKILTKDAV
FTNSVGVGCKVVLEDEQGEEDCYTILGPWDANPEEKILSLKSKLAQEMVGKTVGESVLFQGKKHKIKQISSIWD
>Mature_714_residues
MDYLEKLQSLMENHPSDFFSLWEEYCFNDVVSGDELIVLLEKIKSSSIAPAFGKIAESVIPLWEQLPESEEKDKVLSLVF
DIQTTNSKRLLELALQQVKKYEDSPNYKEALRIVGLRDGIFFTHCLRHFALLMHLCEGNFVFHQGGWGVGEIMGVSFLQQ
KVLVEFEGVLTAKDISFETAFRMLSPLKKDHFLARRFGDPDAFEAFARKDPVAVIECLLKDLGPKNAKEIRNELVGLVIP
EEDWSRWWQSAKIKMKKDSHILAPTSSKDPYIFDPKGFSFISQLQASLSGSNDASKKIASCYTFVRDLGSELKDEANRQF
VIKELKSLDLPADSALSIQRAMLLSEFLGDKSSELDCENIAKLSEDQMFDIVNHIEILSFQKSFLSLIHSCSPAWVSVFT
KILLTTSTSILRDQVFKALIVDKKARESILEKVSAMIEQPLLYPELFVWLFLRVVSGEDGLFSESDRKEIGRQMLASALE
FMHKVAGSPQKDLGKKLYSFLVGQRFLAIRQIIENASIDYLKEFVLLSSKCPQFTQGDLGVLRSLAEVVQPALKRRVAEE
ENILWTTSESFTRMKAKLQSLIGKEMVDNAKEIEDARALGDLRENSEYKFALERRARLQEEIRVLSEEINRAKILTKDAV
FTNSVGVGCKVVLEDEQGEEDCYTILGPWDANPEEKILSLKSKLAQEMVGKTVGESVLFQGKKHKIKQISSIWD

Specific function: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary

COG id: COG1747

COG function: function code S; Uncharacterized N-terminal domain of the transcription elongation factor GreA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GRAD1 (greA associated 1) domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GREA_CHLMU (Q9PLU1)

Other databases:

- EMBL:   AE002160
- PIR:   E81751
- RefSeq:   NP_296388.1
- ProteinModelPortal:   Q9PLU1
- SMR:   Q9PLU1
- GeneID:   1245527
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0004
- TIGR:   TC_0004
- HOGENOM:   HBG402689
- OMA:   EYKFALE
- ProtClustDB:   PRK06330
- BioCyc:   CMUR243161:TC_0004-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00105
- InterPro:   IPR018151
- InterPro:   IPR006359
- InterPro:   IPR001437
- InterPro:   IPR022691
- Gene3D:   G3DSA:1.10.287.180
- Gene3D:   G3DSA:3.10.50.30
- TIGRFAMs:   TIGR01462

Pfam domain/function: PF01272 GreA_GreB; PF03449 GreA_GreB_N; SSF46557 GreA_GreB

EC number: NA

Molecular weight: Translated: 80981; Mature: 80981

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00829 GREAB_1; PS00830 GREAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYLEKLQSLMENHPSDFFSLWEEYCFNDVVSGDELIVLLEKIKSSSIAPAFGKIAESVI
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
PLWEQLPESEEKDKVLSLVFDIQTTNSKRLLELALQQVKKYEDSPNYKEALRIVGLRDGI
HHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHH
FFTHCLRHFALLMHLCEGNFVFHQGGWGVGEIMGVSFLQQKVLVEFEGVLTAKDISFETA
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHH
FRMLSPLKKDHFLARRFGDPDAFEAFARKDPVAVIECLLKDLGPKNAKEIRNELVGLVIP
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHEEECC
EEDWSRWWQSAKIKMKKDSHILAPTSSKDPYIFDPKGFSFISQLQASLSGSNDASKKIAS
CHHHHHHHHHCCEEEECCCEEECCCCCCCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHH
CYTFVRDLGSELKDEANRQFVIKELKSLDLPADSALSIQRAMLLSEFLGDKSSELDCENI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
AKLSEDQMFDIVNHIEILSFQKSFLSLIHSCSPAWVSVFTKILLTTSTSILRDQVFKALI
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDKKARESILEKVSAMIEQPLLYPELFVWLFLRVVSGEDGLFSESDRKEIGRQMLASALE
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
FMHKVAGSPQKDLGKKLYSFLVGQRFLAIRQIIENASIDYLKEFVLLSSKCPQFTQGDLG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHH
VLRSLAEVVQPALKRRVAEEENILWTTSESFTRMKAKLQSLIGKEMVDNAKEIEDARALG
HHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLRENSEYKFALERRARLQEEIRVLSEEINRAKILTKDAVFTNSVGVGCKVVLEDEQGEE
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
DCYTILGPWDANPEEKILSLKSKLAQEMVGKTVGESVLFQGKKHKIKQISSIWD
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDYLEKLQSLMENHPSDFFSLWEEYCFNDVVSGDELIVLLEKIKSSSIAPAFGKIAESVI
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
PLWEQLPESEEKDKVLSLVFDIQTTNSKRLLELALQQVKKYEDSPNYKEALRIVGLRDGI
HHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHH
FFTHCLRHFALLMHLCEGNFVFHQGGWGVGEIMGVSFLQQKVLVEFEGVLTAKDISFETA
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHH
FRMLSPLKKDHFLARRFGDPDAFEAFARKDPVAVIECLLKDLGPKNAKEIRNELVGLVIP
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHEEECC
EEDWSRWWQSAKIKMKKDSHILAPTSSKDPYIFDPKGFSFISQLQASLSGSNDASKKIAS
CHHHHHHHHHCCEEEECCCEEECCCCCCCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHH
CYTFVRDLGSELKDEANRQFVIKELKSLDLPADSALSIQRAMLLSEFLGDKSSELDCENI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
AKLSEDQMFDIVNHIEILSFQKSFLSLIHSCSPAWVSVFTKILLTTSTSILRDQVFKALI
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDKKARESILEKVSAMIEQPLLYPELFVWLFLRVVSGEDGLFSESDRKEIGRQMLASALE
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
FMHKVAGSPQKDLGKKLYSFLVGQRFLAIRQIIENASIDYLKEFVLLSSKCPQFTQGDLG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHH
VLRSLAEVVQPALKRRVAEEENILWTTSESFTRMKAKLQSLIGKEMVDNAKEIEDARALG
HHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLRENSEYKFALERRARLQEEIRVLSEEINRAKILTKDAVFTNSVGVGCKVVLEDEQGEE
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
DCYTILGPWDANPEEKILSLKSKLAQEMVGKTVGESVLFQGKKHKIKQISSIWD
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935