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The map label for this gene is lctP

Identifier: 16120275

GI number: 16120275

Start: 304507

End: 306123

Strand: Direct

Name: lctP

Synonym: VNG6383G

Alternate gene names: 16120275

Gene position: 304507-306123 (Clockwise)

Preceding gene: 16120272

Following gene: 16120284

Centisome position: 83.33

GC content: 63.14

Gene sequence:

>1617_bases
ATGGGTGTCGGGTGGCTGCTCGCGGCCGGAATCGGACTCACGTACTGGAGTATGGAGCCCACCTGGTTGGTGGCCTCGGC
CGTCTACGGCGCGCTGCAGGCCGTCGACATCATCCTCATCGTCTTCGGGGCGATCCTCCTGATGAACTACCTCGAGGGGA
GTGGCGCCATTGCTACGATCAGGTGGTACTTCGGGCAGATCGAAGAAGACCGGCGCATCCAGGTGCTGCTCATCGGTCTC
GGGTTCATGACCATCATCGAAGGTGCAGCCGGGTTCGGGACACCGGGAGCACTCGCCGCACCGCTGTTCATCGGCCTCGG
ATTCCCCCCGTTGGCCGCTGCGGTGTTCGGGCTTTATTTCAACGCCCCGAACCCGCCGTTCGGTGCCGCCGGCACGCCTG
TCATCGGCGGCACCGGTGCCGTCATCGACCCAGCGCTGTCCGGGTCGGTGAGTGTATCCGAGTTCCTCTCGATGGTCTCC
GCATGGACTGGCGTCGTCACGGGAGTGACGTACGTGTTCTGGGGACTGCTCGGCGTGTTCTTCCTGACGTACTGGTTCGG
GAACGGTGACGGTGAACGCAGCATCGGAACCGCCGTGCGTAGCACTCTCCCCATCGCGCCGTTCGCGCTCCTGCTCGGCG
TCGTCACTGGTGGCACACAGCTGGTAATCGCGTGGTTCGTCGGGCCTGCACTCCCCGATATCGCCGCAGGGTTCGTGGTG
CTCGGCATCGGTCTCCTGCTCGCAAAAAACGATATCCTCATCCCTGATGACCAGTGGGACTTCCCCGAGGAATCGACATG
GAGCGACACGTGGCTCGGCGGCCTCGATCTTGACGAGGTGTCCCGTGACCAACCCAAAAAGGAGATGTCTGTGCTGTTGG
CGTGGACCCCGTACCTGCTCGTTGCGCTCGCACTGCTCGTCACGCGGTGGCCGGACCTCACGGTCGCCGGCGTCGCCGTC
CTCGACTGGATCCAGAGTTTTTCCGTCGGACTCGACTCGATCCTCGGTACTGAACTCGGATACACTCTTCAGTACCTCTA
TCTCCCCGGAACGATGCCGTTCATCCCCATCGCGATCCTCACTGGCTTCCTTCACAAGATGGACACCACACAGATGGGGG
AAGCGTGGCGACGGTCGATCCAGCAGATCGCTCCGGCCGCCCTCACGCTCATTATCGCCGTCTCGATGACGCAGATAATG
ATTCAGTCGCAGACGAACACCGCCGACCTCCTCGGCATGATGGAGGCACTCAGCCGCGCGCTCGCGATGGGCGCCGGCGG
CCTGCTCCCGCTCATCTCGCCGTGGATCGGCGCTATCGGCTCGTTCATGACGGGGAGCAACACGTCCTCAAACATCCTCT
TCAGCGTACTCCAGTACAACGCCGCCGAGACGGTCGGCGTCTCCCGGGTGATCGCCGTCAGCCTGCAGAACGTCGGCGGC
GGCCTCGGAAACATGGTCTCGGTGTTGAACGTGGCCGCTATCTGTGGTGTCGTTGGAATCACTGGGCGTGAAGGCGACCT
CCTGCGGAAAGCGATCATCCCGATGGCGCTGTTCGCTGTCTTCGCCGGCCTGTTCGGGATGCTGCTGACGTACGTTCTGG
TTCCCGGCCTGTTCTGA

Upstream 100 bases:

>100_bases
AACCATGCCTAATGTTCTCATACTGGCTCTCGTCGGCGTCGTCCCGATCGGCGTCGCGTTCGTACTGCTCGCTGGGCTCC
GGTGGTCCGCTGCCCGCGCA

Downstream 100 bases:

>100_bases
CCCCGGTCGACGACGTACCGGGGCTCCGCCGCTTCCGGAATCGAAACGAGGTGAACGAATAGAACGAGCCAAAACGAACT
CACCGAACTCGTACTGCTCG

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MGVGWLLAAGIGLTYWSMEPTWLVASAVYGALQAVDIILIVFGAILLMNYLEGSGAIATIRWYFGQIEEDRRIQVLLIGL
GFMTIIEGAAGFGTPGALAAPLFIGLGFPPLAAAVFGLYFNAPNPPFGAAGTPVIGGTGAVIDPALSGSVSVSEFLSMVS
AWTGVVTGVTYVFWGLLGVFFLTYWFGNGDGERSIGTAVRSTLPIAPFALLLGVVTGGTQLVIAWFVGPALPDIAAGFVV
LGIGLLLAKNDILIPDDQWDFPEESTWSDTWLGGLDLDEVSRDQPKKEMSVLLAWTPYLLVALALLVTRWPDLTVAGVAV
LDWIQSFSVGLDSILGTELGYTLQYLYLPGTMPFIPIAILTGFLHKMDTTQMGEAWRRSIQQIAPAALTLIIAVSMTQIM
IQSQTNTADLLGMMEALSRALAMGAGGLLPLISPWIGAIGSFMTGSNTSSNILFSVLQYNAAETVGVSRVIAVSLQNVGG
GLGNMVSVLNVAAICGVVGITGREGDLLRKAIIPMALFAVFAGLFGMLLTYVLVPGLF

Sequences:

>Translated_538_residues
MGVGWLLAAGIGLTYWSMEPTWLVASAVYGALQAVDIILIVFGAILLMNYLEGSGAIATIRWYFGQIEEDRRIQVLLIGL
GFMTIIEGAAGFGTPGALAAPLFIGLGFPPLAAAVFGLYFNAPNPPFGAAGTPVIGGTGAVIDPALSGSVSVSEFLSMVS
AWTGVVTGVTYVFWGLLGVFFLTYWFGNGDGERSIGTAVRSTLPIAPFALLLGVVTGGTQLVIAWFVGPALPDIAAGFVV
LGIGLLLAKNDILIPDDQWDFPEESTWSDTWLGGLDLDEVSRDQPKKEMSVLLAWTPYLLVALALLVTRWPDLTVAGVAV
LDWIQSFSVGLDSILGTELGYTLQYLYLPGTMPFIPIAILTGFLHKMDTTQMGEAWRRSIQQIAPAALTLIIAVSMTQIM
IQSQTNTADLLGMMEALSRALAMGAGGLLPLISPWIGAIGSFMTGSNTSSNILFSVLQYNAAETVGVSRVIAVSLQNVGG
GLGNMVSVLNVAAICGVVGITGREGDLLRKAIIPMALFAVFAGLFGMLLTYVLVPGLF
>Mature_537_residues
GVGWLLAAGIGLTYWSMEPTWLVASAVYGALQAVDIILIVFGAILLMNYLEGSGAIATIRWYFGQIEEDRRIQVLLIGLG
FMTIIEGAAGFGTPGALAAPLFIGLGFPPLAAAVFGLYFNAPNPPFGAAGTPVIGGTGAVIDPALSGSVSVSEFLSMVSA
WTGVVTGVTYVFWGLLGVFFLTYWFGNGDGERSIGTAVRSTLPIAPFALLLGVVTGGTQLVIAWFVGPALPDIAAGFVVL
GIGLLLAKNDILIPDDQWDFPEESTWSDTWLGGLDLDEVSRDQPKKEMSVLLAWTPYLLVALALLVTRWPDLTVAGVAVL
DWIQSFSVGLDSILGTELGYTLQYLYLPGTMPFIPIAILTGFLHKMDTTQMGEAWRRSIQQIAPAALTLIIAVSMTQIMI
QSQTNTADLLGMMEALSRALAMGAGGLLPLISPWIGAIGSFMTGSNTSSNILFSVLQYNAAETVGVSRVIAVSLQNVGGG
LGNMVSVLNVAAICGVVGITGREGDLLRKAIIPMALFAVFAGLFGMLLTYVLVPGLF

Specific function: May play a role in L-lactate transport [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=512, Percent_Identity=29.296875, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1790031, Length=548, Percent_Identity=28.2846715328467, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 56671; Mature: 56540

Theoretical pI: Translated: 4.08; Mature: 4.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVGWLLAAGIGLTYWSMEPTWLVASAVYGALQAVDIILIVFGAILLMNYLEGSGAIATI
CCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
RWYFGQIEEDRRIQVLLIGLGFMTIIEGAAGFGTPGALAAPLFIGLGFPPLAAAVFGLYF
EHHHCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHC
NAPNPPFGAAGTPVIGGTGAVIDPALSGSVSVSEFLSMVSAWTGVVTGVTYVFWGLLGVF
CCCCCCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLTYWFGNGDGERSIGTAVRSTLPIAPFALLLGVVTGGTQLVIAWFVGPALPDIAAGFVV
HHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCHHEEHHHHHCCCCHHHHHHHHH
LGIGLLLAKNDILIPDDQWDFPEESTWSDTWLGGLDLDEVSRDQPKKEMSVLLAWTPYLL
HHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
VALALLVTRWPDLTVAGVAVLDWIQSFSVGLDSILGTELGYTLQYLYLPGTMPFIPIAIL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHH
TGFLHKMDTTQMGEAWRRSIQQIAPAALTLIIAVSMTQIMIQSQTNTADLLGMMEALSRA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LAMGAGGLLPLISPWIGAIGSFMTGSNTSSNILFSVLQYNAAETVGVSRVIAVSLQNVGG
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
GLGNMVSVLNVAAICGVVGITGREGDLLRKAIIPMALFAVFAGLFGMLLTYVLVPGLF
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GVGWLLAAGIGLTYWSMEPTWLVASAVYGALQAVDIILIVFGAILLMNYLEGSGAIATI
CCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
RWYFGQIEEDRRIQVLLIGLGFMTIIEGAAGFGTPGALAAPLFIGLGFPPLAAAVFGLYF
EHHHCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHC
NAPNPPFGAAGTPVIGGTGAVIDPALSGSVSVSEFLSMVSAWTGVVTGVTYVFWGLLGVF
CCCCCCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLTYWFGNGDGERSIGTAVRSTLPIAPFALLLGVVTGGTQLVIAWFVGPALPDIAAGFVV
HHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCHHEEHHHHHCCCCHHHHHHHHH
LGIGLLLAKNDILIPDDQWDFPEESTWSDTWLGGLDLDEVSRDQPKKEMSVLLAWTPYLL
HHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
VALALLVTRWPDLTVAGVAVLDWIQSFSVGLDSILGTELGYTLQYLYLPGTMPFIPIAIL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHH
TGFLHKMDTTQMGEAWRRSIQQIAPAALTLIIAVSMTQIMIQSQTNTADLLGMMEALSRA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LAMGAGGLLPLISPWIGAIGSFMTGSNTSSNILFSVLQYNAAETVGVSRVIAVSLQNVGG
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
GLGNMVSVLNVAAICGVVGITGREGDLLRKAIIPMALFAVFAGLFGMLLTYVLVPGLF
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]