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The map label for this gene is trpS

Identifier: 13357733

GI number: 13357733

Start: 214981

End: 215982

Strand: Reverse

Name: trpS

Synonym: UU175

Alternate gene names: 13357733

Gene position: 215982-214981 (Counterclockwise)

Preceding gene: 13357738

Following gene: 13357732

Centisome position: 28.73

GC content: 27.25

Gene sequence:

>1002_bases
ATGAAAAGACTAATTTCAGGAATTCAACCAACTAATAATTTAACATTAGGAAATTATTTAGGTGCAATTAAAAACTTTGT
TGATTTACAAGATGATTATGAAGTGTTTTTATTTGTTGCGGATTTACATTCCTTAACACCAAATATTTTTGATAACACTG
ATTTTTCTACTACTAAACGTCAGATTATCGCGACATATTTAGCTGCTGGTATTGATCCTAAAAAAACATGTCTATTTTAC
CAATCAGATATCTTATCGATTCCATTATTAGCTCACATATTATTATGTTCAACAAGTATTGGTGAACTAACGCGTATGAC
ACAATTTAAAGATAAAAGTATTAAAGCAACAAAGATGGCTAATAACACTGAAATGATTCCTTCTGGTTTATTAACATATC
CCACATTAATGGCAGCAGATATTTTAACTTTTAATGCAGATGTTGTTCCTGTTGGCCAAGATCAAAAACAACATTTGGAA
TTAACAAGAACGCTTGCTGACCGTTTTAATAAAAGATATGGTAATACTTTTAAATTGCCTCAAGTTTATATTCCTAAAAT
AGGGGCAAAAATTATGGATTTATTAGATCCTAATATTAAAATGTCAAAATCTTCTAAAAACCTTAAGGGTGTGATTTTTT
TAAATGATTCAAAGGATATAATTTTTAAAAAAATTAAAGGAGCTTTAACAGATAATTTAAACAAAGTTAAATATGATTTA
ACATTACAACCAGGAGTAAGTAATTTAATGACAATTTATGCTTGTTTAACAAATCTAAGCTTTAAAGAAATCGAACTAAA
ATACCAACAACAAAACTATGGTGTTTTTAAAAATGATTTAGCCAATATCGTTGCTGATTTTTTAGAAAAGCTGCAACAAA
AAATTTCTTATTGATTAAATAGTCCAGAATTAGATATAATGATAGACAATAGTTGCGAGCGTGCTAACGATATTGCTTAT
CAAAATGTACAACTAGTTTTAAAACATATGCAACTAAAATAA

Upstream 100 bases:

>100_bases
TAATTACAATTTTACTTATATAATAATTAAGTATACAAAAAAAACATTAATTTTAAATGTTTAATTGTATTAACGTTTAA
GTAAGGTAAAATAAAACATT

Downstream 100 bases:

>100_bases
TAGTATATAATGAGGTAAAAAATTAATGGGAAAAAACAACAAATATTTAATTGCTTGTGATCTAGATGGAACACTTTTAA
ATAATGATAGTGATATATCA

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKRLISGIQPTNNLTLGNYLGAIKNFVDLQDDYEVFLFVADLHSLTPNIFDNTDFSTTKRQIIATYLAAGIDPKKTCLFY
QSDILSIPLLAHILLCSTSIGELTRMTQFKDKSIKATKMANNTEMIPSGLLTYPTLMAADILTFNADVVPVGQDQKQHLE
LTRTLADRFNKRYGNTFKLPQVYIPKIGAKIMDLLDPNIKMSKSSKNLKGVIFLNDSKDIIFKKIKGALTDNLNKVKYDL
TLQPGVSNLMTIYACLTNLSFKEIELKYQQQNYGVFKNDLANIVADFLEKLQQKISYWLNSPELDIMIDNSCERANDIAY
QNVQLVLKHMQLK

Sequences:

>Translated_333_residues
MKRLISGIQPTNNLTLGNYLGAIKNFVDLQDDYEVFLFVADLHSLTPNIFDNTDFSTTKRQIIATYLAAGIDPKKTCLFY
QSDILSIPLLAHILLCSTSIGELTRMTQFKDKSIKATKMANNTEMIPSGLLTYPTLMAADILTFNADVVPVGQDQKQHLE
LTRTLADRFNKRYGNTFKLPQVYIPKIGAKIMDLLDPNIKMSKSSKNLKGVIFLNDSKDIIFKKIKGALTDNLNKVKYDL
TLQPGVSNLMTIYACLTNLSFKEIELKYQQQNYGVFKNDLANIVADFLEKLQQKISY*LNSPELDIMIDNSCERANDIAY
QNVQLVLKHMQLK
>Mature_333_residues
MKRLISGIQPTNNLTLGNYLGAIKNFVDLQDDYEVFLFVADLHSLTPNIFDNTDFSTTKRQIIATYLAAGIDPKKTCLFY
QSDILSIPLLAHILLCSTSIGELTRMTQFKDKSIKATKMANNTEMIPSGLLTYPTLMAADILTFNADVVPVGQDQKQHLE
LTRTLADRFNKRYGNTFKLPQVYIPKIGAKIMDLLDPNIKMSKSSKNLKGVIFLNDSKDIIFKKIKGALTDNLNKVKYDL
TLQPGVSNLMTIYACLTNLSFKEIELKYQQQNYGVFKNDLANIVADFLEKLQQKISY*LNSPELDIMIDNSCERANDIAY
QNVQLVLKHMQLK

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=333, Percent_Identity=36.9369369369369, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI41352700, Length=185, Percent_Identity=44.3243243243243, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1789786, Length=326, Percent_Identity=41.7177914110429, Blast_Score=251, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71982800, Length=330, Percent_Identity=35.7575757575758, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71982793, Length=330, Percent_Identity=35.7575757575758, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6320474, Length=341, Percent_Identity=37.8299120234604, Blast_Score=192, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24666151, Length=338, Percent_Identity=35.5029585798817, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 37551; Mature: 37551

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLISGIQPTNNLTLGNYLGAIKNFVDLQDDYEVFLFVADLHSLTPNIFDNTDFSTTKR
CCHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCEEEEEEEHHHHCCCCCCCCCCCCHHHH
QIIATYLAAGIDPKKTCLFYQSDILSIPLLAHILLCSTSIGELTRMTQFKDKSIKATKMA
HHHHHHHHHCCCCHHEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHCCC
NNTEMIPSGLLTYPTLMAADILTFNADVVPVGQDQKQHLELTRTLADRFNKRYGNTFKLP
CCCCCCCCCHHHHHHHHHHHHHEECCCEEECCCCHHHHHHHHHHHHHHHHHHCCCEECCC
QVYIPKIGAKIMDLLDPNIKMSKSSKNLKGVIFLNDSKDIIFKKIKGALTDNLNKVKYDL
CHHHHHHHHHHHHHHCCCCEECCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEE
TLQPGVSNLMTIYACLTNLSFKEIELKYQQQNYGVFKNDLANIVADFLEKLQQKISYLNS
EECCCHHHHHHHHHHHHCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PELDIMIDNSCERANDIAYQNVQLVLKHMQLK
CCEEEEECCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRLISGIQPTNNLTLGNYLGAIKNFVDLQDDYEVFLFVADLHSLTPNIFDNTDFSTTKR
CCHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCEEEEEEEHHHHCCCCCCCCCCCCHHHH
QIIATYLAAGIDPKKTCLFYQSDILSIPLLAHILLCSTSIGELTRMTQFKDKSIKATKMA
HHHHHHHHHCCCCHHEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHCCC
NNTEMIPSGLLTYPTLMAADILTFNADVVPVGQDQKQHLELTRTLADRFNKRYGNTFKLP
CCCCCCCCCHHHHHHHHHHHHHEECCCEEECCCCHHHHHHHHHHHHHHHHHHCCCEECCC
QVYIPKIGAKIMDLLDPNIKMSKSSKNLKGVIFLNDSKDIIFKKIKGALTDNLNKVKYDL
CHHHHHHHHHHHHHHCCCCEECCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEE
TLQPGVSNLMTIYACLTNLSFKEIELKYQQQNYGVFKNDLANIVADFLEKLQQKISYLNS
EECCCHHHHHHHHHHHHCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PELDIMIDNSCERANDIAYQNVQLVLKHMQLK
CCEEEEECCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11048724 [H]